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Brief Title: Early Detection of Pancreatic Adenocarcinoma (PDAC) Using a Panel of Biomarkers
Official Title: Early Detection of Pancreatic Adenocarcinoma (PDAC) Using a Panel of Biomarkers (UroPanc)
Study ID: NCT04449406
Brief Summary: Urine and blood samples are being collected from patients with and without diseases of the pancreas. These samples will be tested with the aim of developing an accurate way of diagnosing diseases of the pancreas using the results.
Detailed Description: The main aim of this research study is to establish the accuracy of a urinary biomarker panel (LYVE1, REG1B, TFF1), and affiliated PancRISK score alone or in combination with plasma CA19-9 for early detection of pancreatic ductal adenocarcinoma (PDAC). Samples will be collected from symptomatic individuals with suspected pancreatic cancer, and asymptomatic subjects at risk of developing PDAC. The results of urine biomarker and CA19-9 analysis carried out on these samples will be compared to the imaging and, where available, histopathology data, which will inform the development of a predictive model to detect PDAC earlier.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: Yes
EUROPAC study, University of Liverpool, Liverpool, , United Kingdom
ADEPTS study, University College London, London, , United Kingdom
Imperial College London, London, , United Kingdom
Royal London Hospital, London, , United Kingdom
Name: Tatjana Crnogorac-Jurcevic, MD, PhD
Affiliation: Queen Mary University of London
Role: PRINCIPAL_INVESTIGATOR