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Spots Global Cancer Trial Database for Early Detection of Pancreatic Adenocarcinoma (PDAC) Using a Panel of Biomarkers

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Trial Identification

Brief Title: Early Detection of Pancreatic Adenocarcinoma (PDAC) Using a Panel of Biomarkers

Official Title: Early Detection of Pancreatic Adenocarcinoma (PDAC) Using a Panel of Biomarkers (UroPanc)

Study ID: NCT04449406

Interventions

Study Description

Brief Summary: Urine and blood samples are being collected from patients with and without diseases of the pancreas. These samples will be tested with the aim of developing an accurate way of diagnosing diseases of the pancreas using the results.

Detailed Description: The main aim of this research study is to establish the accuracy of a urinary biomarker panel (LYVE1, REG1B, TFF1), and affiliated PancRISK score alone or in combination with plasma CA19-9 for early detection of pancreatic ductal adenocarcinoma (PDAC). Samples will be collected from symptomatic individuals with suspected pancreatic cancer, and asymptomatic subjects at risk of developing PDAC. The results of urine biomarker and CA19-9 analysis carried out on these samples will be compared to the imaging and, where available, histopathology data, which will inform the development of a predictive model to detect PDAC earlier.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: Yes

Locations

EUROPAC study, University of Liverpool, Liverpool, , United Kingdom

ADEPTS study, University College London, London, , United Kingdom

Imperial College London, London, , United Kingdom

Royal London Hospital, London, , United Kingdom

Contact Details

Name: Tatjana Crnogorac-Jurcevic, MD, PhD

Affiliation: Queen Mary University of London

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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