Spots Global Cancer Trial Database for Yield of Cryoprobe vs Flexible Forceps Pleural Biopsy

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Trial Identification

Brief Title: Yield of Cryoprobe vs Flexible Forceps Pleural Biopsy

Official Title: A Study to Evaluate the Yield of Pleural Biopsy With a Flexible Cryoprobe Versus Flexible Forceps During Semirigid Thoracoscopy: a Comparative Study

Study ID: NCT02500277

Conditions

Pleural Effusion

Pleurisy

Tuberculosis

Metastatic Malignancy

Interventions

Cryoprobe pleural biopsy first

Flexible forceps biopsy first

Study Description

Brief Summary: This is a prospective study to assess the yield of pleural biopsy obtained with the routine flexible thoracoscopic biopsy forceps versus that obtained with a flexible cryoprobe during semirigid thoracoscopy

Detailed Description: Consecutive patients with exudative pleural effusions who are planned to undergo semirigid thoracoscopy will be enrolled in the study if they satisfy the inclusion criteria. They will be randomized in 1:1 ratio using a computer-generated randomization sequence to the following groups: Group A: Four pleural biopsy specimens obtained using the flexible cryoprobe followed by eight pleural biopsy specimens obtained using the flexible thoracoscopic forceps OR Group B: The above two procedures will be performed in the reverse order The biopsies will be performed from different areas of the involved pleura with the two techniques. Thoracoscopy will be performed in the bronchoscopy suite on spontaneously breathing subjects (fasting for 8 h) under conscious sedation (using midazolam, pentazocine, and tramadol) observing complete aseptic precautions.