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Spots Global Cancer Trial Database for Adipose Tissue Function and Response to Exercise Training in Women With and Without Polycystic Ovary Syndrome

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Trial Identification

Brief Title: Adipose Tissue Function and Response to Exercise Training in Women With and Without Polycystic Ovary Syndrome

Official Title: Adipose Tissue Function and Response to Exercise Training in Women With and Without Polycystic Ovary Syndrome

Study ID: NCT02943291

Study Description

Brief Summary: The primary aim of this trial is to investigate adipose tissue function in women with and without polycystic ovary syndrome (PCOS). PCOS is a common endocrine disorder in young women. The pathogenesis behind PCOS is complex and only partly understood, and deeper mechanistic insight is needed. Insulin resistance is a central feature of PCOS, and recent studies have suggested that this is linked to aberrant adipose tissue function. Exercise training has been found to improve the symptoms in PCOS, but we need more knowledge about why. While processes involved in skeletal muscle oxidative remodeling are well described, it is to a large extent unknown whether the oxidative capacity of human adipose tissue is modified by endurance training. The women included in this study will be matched (for body mass index, body weight, and age) to participants in another study. This will enable the investigators to do a comparison between cases (women with PCOS) and controls (women without PCOS) at baseline, and to assess the responses to exercise training in adipose tissue.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

Centre of Exercise and Nutrition, Mary MacKillop Institute for Health Research, AUC, Melbourne, , Australia

Department of circulation and medical imaging , NTNU, Trondheim, , Norway

Contact Details

Name: Jorunn L Helbostad, phd prof

Affiliation: Norwegian University of Science and Technology

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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