Symptoms and General Pathology

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Urinary Tract, Sexual Organs, and Pregnancy Conditions

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Syndrome

Polycystic Ovary Syndrome

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Ovarian Diseases

Adnexal Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

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Female Urogenital Diseases and Pregnancy Complications

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4x4 minutes high intensity interval training with 4 minute intervals

10x1 minute high intensity interval training with 1 minute intervals

Treadmill running/walking with 10 minutes warm-up at 60-70% of maximum heart rate, 4x4 minute intervals at 90-95% of maximum heart rate separated by 3-minutes active pauses at 60-70% of maximum heart rate, and 3 minutes cool-down.

4x4 minutes high intensity interval training

Treadmill running/walking with 10 minutes warm-up at 60-70% of maximum heart rate, ten 1-minute intervals at maximal intensity (that can be performed for one minute), separated by 1-minutes active pauses at 60-70% of maximum heart rate, and 3 minutes cool-down.

10x1 minute high intensity interval training

Jorunn L Helbostad, phd prof

The primary aim of this trial is to investigate adipose tissue function in women with and without polycystic ovary syndrome (PCOS). PCOS is a common endocrine disorder in young women. The pathogenesis behind PCOS is complex and only partly understood, and deeper mechanistic insight is needed. Insulin resistance is a central feature of PCOS, and recent studies have suggested that this is linked to aberrant adipose tissue function. Exercise training has been found to improve the symptoms in PCOS, but we need more knowledge about why. While processes involved in skeletal muscle oxidative remodeling are well described, it is to a large extent unknown whether the oxidative capacity of human adipose tissue is modified by endurance training. The women included in this study will be matched (for body mass index, body weight, and age) to participants in another study. This will enable the investigators to do a comparison between cases (women with PCOS) and controls (women without PCOS) at baseline, and to assess the responses to exercise training in adipose tissue.

Adipose Tissue Function and Response to Exercise Training in Women With and Without Polycystic Ovary Syndrome

assessed with high resolution respirometry

quantified using standard Western Blot method

measured by flow-mediated dilatation of the brachial artery

St. Olavs Hospital

Liverpool John Moores University

Australian Catholic University

Norwegian University of Science and Technology

Treadmill running/walking with 10 minutes varm-up at 60-70% of maximum heart rate, 4x4 minute intervals at 90-95% of maximum heart rate separated by 3-minutes active pauses at 60-70% of maximum heart rate, and 3 minutes cool-down.

Treadmill running/walking with 10 minutes varm-up at 60-70% of maximum heart rate, ten 1-minute intervals at maximal intensity (that can be performed for one minute), separated by 1-minutes active pauses at 60-70% of maximum heart rate, and 3 minutes cool-down.

Trine Moholdt, phd

The aim is to investigate whether 16 weeks of high intensity interval training, followed by 36 weeks of home-based exercise, will improve menstrual frequency in women with Polycystic Ovary Syndrome (PCOS) compared with a non-exercising control group.

Improving Reproductive Function in Women With Polycystic Ovary Syndrome by High Intensity Interval Training

Improving Reproductive Function in Women With Polycystic Ovary Syndrome by High Intensity Interval Training: A Randomized Controlled Trial.

Bioimpedance scale and/or DXA, waist circumference, waist/hip-ratio

Maximal oxygen uptake measured with Oxygon Pro, Jaeger

Flow mediated dilatation of the brachial artery

Ultrasound of the caroid intima-media thickness

carbohydrate- and fat oxidation measured with Oxygon Pro, Jaeger

Systolic and diastolic measured with automatic blood pressure device

PCOS-specific Quality of Life Questionnaire

Physical activity monitor armband (amount and intensity)

In total, between groups, and among those trying to become pregnant when entering the study

Physical Activity Enjoyment Scale (PACES) questionnaire

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Adipose Tissue Function and Response to Exercise Training in Women With and Without Polycystic Ovary Syndrome	NCT02943291	Polycystic Ovar...	4x4 minutes hig... 10x1 minute hig...	18 Years - 45 Years	Norwegian University of Science and Technology
Improving Reproductive Function in Women With Polycystic Ovary Syndrome by High Intensity Interval Training	NCT02419482	Polycystic Ovar...	4x4 minutes hig... 10x1 minute hig...	18 Years - 45 Years	Norwegian University of Science and Technology

Spots Global Cancer Trial Database for 10x1 minute high intensity interval training