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Spots Global Cancer Trial Database for Endocan Levels at Polycystic Ovary Syndrome and Periodontal Inflammation

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Trial Identification

Brief Title: Endocan Levels at Polycystic Ovary Syndrome and Periodontal Inflammation

Official Title: The Levels of Interleukin-6 and Endocan at Individuals With Polycystic Ovary Syndrome and Periodontal Inflammation

Study ID: NCT03264846

Study Description

Brief Summary: Periodontal diseases are chronic inflammatory disease occurred by the interaction between pathogenic microorganism and the host defense. Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disease associated with increased risk of cardiovascular events. Endocan is a proteoglycan secreted mainly by endothelial cells under the control of inflammatory cytokines. Periodontal diseases, including gingivitis, are common chronic infectious diseases caused by predominantly pathogenic microorganisms that colonize the subgingival area and cause local and systemic elevations of proinflammatory cytokines such as Interleukin-6 (IL-6). Several lines of evidence established the association between periodontal and systemic diseases, including metabolic syndrome, diabetes, and cardiovascular disease. Because of the fact that both periodontal disease and PCOS are associated with systemic inflammation and insulin resistance, these two disorders may be linked through a common pathophysiologic pathway. A number of studies have indicated a possible relationship between PCOS and periodontal inflammation. Despite common risk factors, including oxidative stress, the relationship between chronic periodontitis (CP) and PCOS remains unclear. The aims of the study were to determine serum and saliva Endocan and IL-6 levels and to evaluate the correlation between these two biomarker in women with periodontal disease and PCOS.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT

Sex: FEMALE

Healthy Volunteers: Yes

Locations

Ebru Sağlam, İstanbul, Eyalet/Yerleşke, Turkey

Contact Details

Name: Ebru Sağlam, PhD

Affiliation: Bezmialem Vakif University

Role: STUDY_DIRECTOR

Name: Ayşe Toraman

Affiliation: Ataturk University

Role: PRINCIPAL_INVESTIGATOR

Name: Engin Şebin

Affiliation: Erzurum Regional Training and Research Hospital

Role: PRINCIPAL_INVESTIGATOR

Name: Cenk Fatih Çanakçı, Professor

Affiliation: Ataturk University

Role: STUDY_CHAIR

Name: Hümeyra Çanakçı, Dr

Affiliation: Private Practice

Role: PRINCIPAL_INVESTIGATOR

Name: Metin İngeç, Professor

Affiliation: Ataturk University

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

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