Symptoms and General Pathology

All Conditions

Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Gland and Hormone Related Diseases

Infections

Mouth and Tooth Diseases

Syndrome

Inflammation

Polycystic Ovary Syndrome

Gingivitis

Cysts

Ovarian Cysts

Ovarian Diseases

Adnexal Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Gonadal Disorders

Endocrine System Diseases

Communicable Diseases

Gingival Diseases

Periodontal Diseases

Mouth Diseases

Stomatognathic Diseases

PCOS participants with periodontally healthy

systemically healthy participants with periodontitis

systemically and periodontally healthy participants

Whole saliva samples were obtained via expectorating into polypropylene tubes venous blood were obtained from the antecubital vein via the standard venipuncture method.

Collection of Serum and Saliva Samples

Ebru Sağlam, PhD

Ayşe Toraman

Engin Şebin

Cenk Fatih Çanakçı, Professor

Hümeyra Çanakçı, Dr

Metin İngeç, Professor

Periodontal diseases are chronic inflammatory disease occurred by the interaction between pathogenic microorganism and the host defense. Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disease associated with increased risk of cardiovascular events. Endocan is a proteoglycan secreted mainly by endothelial cells under the control of inflammatory cytokines.

Periodontal diseases, including gingivitis, are common chronic infectious diseases caused by predominantly pathogenic microorganisms that colonize the subgingival area and cause local and systemic elevations of proinflammatory cytokines such as Interleukin-6 (IL-6).

Several lines of evidence established the association between periodontal and systemic diseases, including metabolic syndrome, diabetes, and cardiovascular disease.

Because of the fact that both periodontal disease and PCOS are associated with systemic inflammation and insulin resistance, these two disorders may be linked through a common pathophysiologic pathway.

A number of studies have indicated a possible relationship between PCOS and periodontal inflammation. Despite common risk factors, including oxidative stress, the relationship between chronic periodontitis (CP) and PCOS remains unclear.

The aims of the study were to determine serum and saliva Endocan and IL-6 levels and to evaluate the correlation between these two biomarker in women with periodontal disease and PCOS.

Endocan Levels at Polycystic Ovary Syndrome and Periodontal Inflammation

The Levels of Interleukin-6 and Endocan at Individuals With Polycystic Ovary Syndrome and Periodontal Inflammation

Enzyme-Linked Immunosorbent Assay (ELISA)

Ataturk University

Ebru Saglam

Principal Investigator, Bezmialem Universitesi, Dentistry Faculty

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Endocan Levels at Polycystic Ovary Syndrome and Periodontal Inflammation	NCT03264846	Polycystic Ovar... Inflammation Gu... Cytokines	Collection of S...	18 Years - 40 Years	Bezmialem Vakif University
Endocan Levels at Polycystic Ovary Syndrome and Periodontal Inflammation	NCT03264846	Polycystic Ovar... Inflammation Gu... Cytokines	Collection of S...	18 Years - 40 Years	Bezmialem Vakif University

Spots Global Cancer Trial Database for collection of serum and saliva samples