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Brief Title: Endocan Levels at Polycystic Ovary Syndrome and Periodontal Inflammation
Official Title: The Levels of Interleukin-6 and Endocan at Individuals With Polycystic Ovary Syndrome and Periodontal Inflammation
Study ID: NCT03264846
Brief Summary: Periodontal diseases are chronic inflammatory disease occurred by the interaction between pathogenic microorganism and the host defense. Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disease associated with increased risk of cardiovascular events. Endocan is a proteoglycan secreted mainly by endothelial cells under the control of inflammatory cytokines. Periodontal diseases, including gingivitis, are common chronic infectious diseases caused by predominantly pathogenic microorganisms that colonize the subgingival area and cause local and systemic elevations of proinflammatory cytokines such as Interleukin-6 (IL-6). Several lines of evidence established the association between periodontal and systemic diseases, including metabolic syndrome, diabetes, and cardiovascular disease. Because of the fact that both periodontal disease and PCOS are associated with systemic inflammation and insulin resistance, these two disorders may be linked through a common pathophysiologic pathway. A number of studies have indicated a possible relationship between PCOS and periodontal inflammation. Despite common risk factors, including oxidative stress, the relationship between chronic periodontitis (CP) and PCOS remains unclear. The aims of the study were to determine serum and saliva Endocan and IL-6 levels and to evaluate the correlation between these two biomarker in women with periodontal disease and PCOS.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT
Sex: FEMALE
Healthy Volunteers: Yes
Ebru Sağlam, İstanbul, Eyalet/Yerleşke, Turkey
Name: Ebru Sağlam, PhD
Affiliation: Bezmialem Vakif University
Role: STUDY_DIRECTOR
Name: Ayşe Toraman
Affiliation: Ataturk University
Role: PRINCIPAL_INVESTIGATOR
Name: Engin Şebin
Affiliation: Erzurum Regional Training and Research Hospital
Role: PRINCIPAL_INVESTIGATOR
Name: Cenk Fatih Çanakçı, Professor
Affiliation: Ataturk University
Role: STUDY_CHAIR
Name: Hümeyra Çanakçı, Dr
Affiliation: Private Practice
Role: PRINCIPAL_INVESTIGATOR
Name: Metin İngeç, Professor
Affiliation: Ataturk University
Role: STUDY_DIRECTOR