Spots Global Cancer Trial Database for Tissue Banking Study - Polycythemia Vera or Essential Thrombocythemia (PV & ET) Patients
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Trial Identification
Brief Title: Tissue Banking Study - Polycythemia Vera or Essential Thrombocythemia (PV & ET) Patients
Official Title: Treatment Strategies for Myeloproliferative Neoplasms by Targeting the Tumor Suppressor P53
Study ID: NCT01970930
Interventions
Study Description
Brief Summary: The purpose of the study is to isolate and characterize stem cells of patients with Polycythemia Vera (PV) and Essential Thrombocythemia (ET) to find out why these cells are not working the way they should be and why they seem to be sensitive to regulatory factors in the blood, such as clotting.
Detailed Description: Specific Aim 1: Assess the effects of RG7112 on MPN HSC/HPC p53 levels and study how it affects MPN stem cell function. Specific Aim 2. Assess the effects of a combination of low doses of IFNα and RG7112 on MPN HSC/HPC.
Keywords
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Icahn School of Medicine at Mount Sinai, New York, New York, United States
Contact Details
Name: Ronald Hoffman, MD
Affiliation: Icahn School of Medicine at Mount Sinai
Role: PRINCIPAL_INVESTIGATOR
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