Spots Global Cancer Trial Database for Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
Trial Identification
Brief Title: Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium
Official Title: Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium: A Multicenter, Randomized, Double-Blind Clinical Trail
Study ID: NCT02928692
Study Description
Brief Summary: Postoperative cognitive dysfunction (POCD) and postoperative delirium occurs mainly in aged patients. POCD and POD may increase the mortality and morbidity. However, the mechanism of POCD is not clear yet and no effective therapy method was proved. According to previous study, the neuroinflammation is the main reason both for POCD and POD. Minocycline is a tetracycline derivative. Due to it's lipophilic structure, it is easy to pass through blood brain barrier and attenuate neuroinflammation. It's neuroprotective effects has been proven in many experimental animal models such as Alzheimer's disease, Huntington's disease and Parkinson's syndrome. In present study, the investigators hypothesized that minocycline would attenuate the incidence of POCD and POD in the aged patients.
Detailed Description:
Eligibility
Minimum Age: 65 Years
Eligible Ages: OLDER_ADULT
Sex: ALL
Healthy Volunteers: Yes
Locations
Scales, Shanghai, Shanghai, China
Shanghai Pudong Hospital, Shanghai, , China
Shanghai Pudong New Area Dongming Community Health Care Center, Shanghai, , China
Shanghai Pudong New Area people's Hopsital, Shanghai, , China
Shanghai Tenth Hospital, Shanghai, , China
Contact Details
Take Control of Your Skin and Body Changes Today.
Try out Spots for free, set up only takes 2 mins.
Join others from around the world:
