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Spots Global Cancer Trial Database for Epidemiologic and Genetic Study on Familial Prostate Cancer

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Trial Identification

Brief Title: Epidemiologic and Genetic Study on Familial Prostate Cancer

Official Title: ProGene: Etude Genetique et Epidemiologique du Cancer de la Prostate Familial

Study ID: NCT01221168

Conditions

Prostate Cancer

Interventions

Study Description

Brief Summary: The aims of the study are: * to identify genetic and molecular factors (rare mutations, polymorphisms) involved in the natural history of prostate cancers and their response to treatment, * to evaluate and deduce their medical applications for screening and therapeutic management of these tumors.

Detailed Description: The impact of genetic factors on the natural history of prostate cancer (PC) is shown schematically at two levels: 1. first, at the constitutional level with germline alterations. Family history is found in 20% of PC patients. Different clinical entities associated with different modes of inheritance, susceptibility mutations or polymorphisms, define different evolutionary patterns. Also, studies suggested that some genetic polymorphisms alter the response to some treatments (such as recurrence after prostatectomy or radiotherapy) or adverse effects of those above (such as toxicity of radiation therapy). 2. secondly, PC is characterized by the accumulation of genetic alterations (somatic alterations or acquired mutations). These changes contribute in varying degrees to the aggressiveness of the disease (such as early metastatic potential) and treatment failure (such as resistance to radiation or hormone resistance). The purpose of this study is to establish a register, with a follow up of cohort type and a collection of biological samples: * For men with known prostate cancer. * For men with no prostate cancer after a screening procedure for this disease, so that their biological samples can be compared to those of men with prostate cancer. The registry data and collected biological samples are used to identify genetic and molecular factors involved in susceptibility, genesis and evolution of prostate cancers.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: Yes

Locations

Department of Urology, CHU Angers, Angers, , France

Department of Urology, Hopital de la Cavale Blanche, Brest, , France

Department of Urology, CHU Dijon, Dijon, , France

Department of Urology, Hopital Pitié-Salpetriere, Paris, , France

Department of Urology, Hopital Tenon, Paris, , France

Contact Details

Name: Olivier Cussenot, MD, Ph.D.

Affiliation: Assistance Publique - Hôpitaux de Paris

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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