Spots Global Cancer Trial Database for Study of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-641/KEYNOTE-641)
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Trial Identification
Brief Title: Study of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-641/KEYNOTE-641)
Official Title: A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (KEYNOTE-641)
Study ID: NCT03834493
Conditions
Study Description
Brief Summary: The purpose of this study is to assess the efficacy and safety of the combination of pembrolizumab (MK-3475) and enzalutamide in the treatment of men with metastatic castration-resistant prostate cancer (mCRPC) who have not received chemotherapy for mCRPC, are abiraterone-naïve, or are intolerant to or progressed on abiraterone acetate. There are two primary study hypotheses. Hypothesis 1: The combination of pembrolizumab plus enzalutamide is superior to placebo plus enzalutamide with respect to Overall Survival (OS). Hypothesis 2: The combination of pembrolizumab plus enzalutamide is superior to placebo plus enzalutamide with respect to Radiographic Progression-free Survival (rPFS) per Prostate Cancer Working Group (PCWG)-modified Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) as assessed by blinded independent central review.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: MALE
Healthy Volunteers: No
Locations
University of South Alabama, Mitchell Cancer Institute ( Site 0065), Mobile, Alabama, United States
St. Joseph Heritage Healthcare ( Site 0069), Fullerton, California, United States
UCLA Hematology/Oncology - Santa Monica ( Site 0081), Los Angeles, California, United States
University of Colorado Cancer Center ( Site 0022), Aurora, Colorado, United States
Smilow Cancer Hospital at Yale New Haven ( Site 0038), New Haven, Connecticut, United States
Moffitt Cancer Center ( Site 0080), Tampa, Florida, United States
Georgia Cancer Center at Augusta University ( Site 0026), Augusta, Georgia, United States
Mount Sinai Hospital Medical Center ( Site 0042), Chicago, Illinois, United States
Methodist Hospitals. ( Site 0008), Merrillville, Indiana, United States
Tulane Cancer Center ( Site 0066), New Orleans, Louisiana, United States
University of Massachusetts Worcester ( Site 0053), Worcester, Massachusetts, United States
Cancer & Hematology Centers of Western Michigan ( Site 0013), Grand Rapids, Michigan, United States
Munson Medical Center ( Site 0030), Traverse City, Michigan, United States
St. Vincent Frontier Cancer Center ( Site 0016), Billings, Montana, United States
Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 0034), Omaha, Nebraska, United States
Comprehensive Cancer Centers of Nevada ( Site 0092), Las Vegas, Nevada, United States
John Theurer Cancer Center at Hackensack University Medical Center ( Site 0004), Hackensack, New Jersey, United States
Associated Medical Professionals of NY ( Site 0060), Syracuse, New York, United States
W. G. Bill Hefner VA Medical Center ( Site 0029), Salisbury, North Carolina, United States
Gabrail Cancer Center-Research ( Site 0096), Canton, Ohio, United States
Tri-State Urologic Services PSC, Inc. ( Site 0094), Cincinnati, Ohio, United States
University Hospitals Cleveland Medical Center ( Site 0036), Cleveland, Ohio, United States
Oregon Health Sciences University ( Site 0031), Portland, Oregon, United States
Carolina Urologic Research Center ( Site 0070), Myrtle Beach, South Carolina, United States
Inova Schar Cancer Institute ( Site 0006), Fairfax, Virginia, United States
Virginia Cancer Institute ( Site 0052), Richmond, Virginia, United States
Blue Ridge Cancer Care ( Site 0086), Roanoke, Virginia, United States
Froedtert Hospital & the Medical College of Wisconsin ( Site 0045), Milwaukee, Wisconsin, United States
Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 1013), Berazategui, Buenos Aires, Argentina
Instituto de Investigaciones Clinicas ( Site 1000), Mar del Plata, Buenos Aires, Argentina
Centro de Diagnostico Urologico ( Site 1008), Buenos Aires, Caba, Argentina
Instituto Medico Alexander Fleming ( Site 1010), Buenos Aires, Caba, Argentina
Sanatorio Parque ( Site 1002), Rosario, Santa Fe, Argentina
Instituto de Oncologia de Rosario ( Site 1015), Rosario, Santa Fe, Argentina
Instituto de Investigaciones Metabolicas [Buenos Aires, Argentina] ( Site 1011), Buenos Aires, , Argentina
Hospital Aleman ( Site 1004), Buenos Aires, , Argentina
Centro Medico Dra De Salvo ( Site 1018), Buenos Aires, , Argentina
CEMAIC ( Site 1014), Cordoba, , Argentina
Centro Oncologico Riojano Integral ( Site 1005), La Rioja, , Argentina
Centro Oncologico de Integracion Regional. COIR ( Site 1007), Mendoza, , Argentina
St. Vincent's Hospital ( Site 0158), Darlinghurst, New South Wales, Australia
St George Hospital ( Site 0157), Kogarah, New South Wales, Australia
Macquarie University ( Site 0151), Macquarie University, New South Wales, Australia
Port Macquarie Base Hospital ( Site 0153), Port Macquarie, New South Wales, Australia
Calvary Mater Newcastle ( Site 0148), Waratah, New South Wales, Australia
Gallipoli Medical Research Foundation ( Site 0149), Greenslopes, Queensland, Australia
Gold Coast University Hospital ( Site 0150), Southport, Queensland, Australia
Royal Adelaide Hospital ( Site 0154), Adelaide, South Australia, Australia
Monash Health-Monash Medical Centre ( Site 0147), Clayton, Victoria, Australia
Fiona Stanley Hospital ( Site 0162), Perth, Western Australia, Australia
Ordensklinikum Linz GmbH Elisabethinen ( Site 0373), Linz, Oberosterreich, Austria
Medizinische Universität Wien ( Site 0375), Wien, , Austria
Hospital Erasto Gaertner-CEPEP - Pesquisa Clínica ( Site 1036), Curitiba, Parana, Brazil
Liga Norte Riograndense Contra o Câncer-Centro de Pesquisa Clínica ( Site 1032), Natal, Rio Grande Do Norte, Brazil
ONCOSITE - Centro de Pesquisa Clinica em Oncologia ( Site 1038), Ijui, Rio Grande Do Sul, Brazil
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 1021), Porto Alegre, Rio Grande Do Sul, Brazil
Centro de Novos Tratamentos Itajai - Clinica de Neoplasias Litoral ( Site 1035), Itajai, Santa Catarina, Brazil
Hospital de Base de Sao Jose de Rio Preto ( Site 1022), Sao Jose do Rio Preto, Sao Paulo, Brazil
Núcleo de Pesquisa Clínica da Rede São Camilo ( Site 1040), São Paulo, Sao Paulo, Brazil
A.C. Camargo Cancer Center ( Site 1026), Sao Paulo, , Brazil
MHAT Serdika-Second Department of Medical Oncology ( Site 0505), Sofia, Sofia (stolitsa), Bulgaria
MHAT Central Hospital ( Site 0503), Plovdiv, , Bulgaria
Complex Cancer Center Plovdiv-First Medical Oncology Department ( Site 0507), Plovdiv, , Bulgaria
BC Cancer - Victoria ( Site 0111), Victoria, British Columbia, Canada
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0116), Hamilton, Ontario, Canada
Grand River Hospital ( Site 0120), Kitchener, Ontario, Canada
Lakeridge Health ( Site 0117), Oshawa, Ontario, Canada
Health Sciences North ( Site 0122), Sudbury, Ontario, Canada
Sunnybrook Research Institute ( Site 0108), Toronto, Ontario, Canada
Princess Margaret Cancer Centre ( Site 0107), Toronto, Ontario, Canada
CISSS de la Monteregie-Centre ( Site 0119), Greenfield Park, Quebec, Canada
Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0106), Montreal, Quebec, Canada
CIUSSS du Bas Saint Laurent - Hopital Regional de Rimouski ( Site 0102), Rimouski, Quebec, Canada
CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0105), Sherbrooke, Quebec, Canada
CHUQ-Univ Laval-Hotel Dieu de Quebec ( Site 0103), Quebec, , Canada
Centro Investigación del Cáncer James Lind ( Site 1041), Temuco, Araucania, Chile
Rey y Oreilly Limitada ( Site 1048), Temuco, Araucania, Chile
Fundacion Arturo Lopez Perez ( Site 1049), Santiago, Region M. De Santiago, Chile
Pontificia Universidad Catolica de Chile ( Site 1047), Santiago, Region M. De Santiago, Chile
Bradfordhill ( Site 1044), Santiago, Region M. De Santiago, Chile
Oncocentro ( Site 1045), Vina del Mar, Valparaiso, Chile
Hospital Pablo Tobon Uribe ( Site 1066), Medellin, Antioquia, Colombia
Biomelab S A S ( Site 1067), Barranquilla, Atlantico, Colombia
Clinica de la Costa Ltda. ( Site 1073), Barranquilla, Atlantico, Colombia
Sociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 1068), Valledupar, Cesar, Colombia
Oncomedica S.A. ( Site 1057), Monteria, Cordoba, Colombia
Clinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 1062), Bogota, Distrito Capital De Bogota, Colombia
Centro Medico Imbanaco de Cali S.A ( Site 1064), Cali, Valle Del Cauca, Colombia
Hemato Oncologos S.A. ( Site 1065), Cali, Valle Del Cauca, Colombia
Fakultni Nemocnice u sv. Anny v Brne-Onkologicko-chirurgicke oddeleni ( Site 1303), Brno, Brno-mesto, Czechia
Nemocnice AGEL Novy Jicin a.s. ( Site 1304), Nový Jičín, Novy Jicin, Czechia
Fakultni nemocnice Olomouc ( Site 1301), Olomouc, , Czechia
C.H. de Saint Quentin ( Site 0481), Saint Quentin, Aisne, France
Clinique Sainte Anne ( Site 0431), Strasbourg, Alsace, France
Centre Jean Perrin ( Site 0434), Clermont-Ferrand, Auvergne, France
CHU de Brest -Site Hopital Morvan ( Site 0441), Brest, Bretagne, France
CHU Jean Minjoz ( Site 0423), Besancon, Doubs, France
Institut Bergonie ( Site 0421), Bordeaux, Gironde, France
Institut Claudius Regaud IUCT Oncopole ( Site 0418), Toulouse, Haute-Garonne, France
Hopital Foch ( Site 0428), Suresnes, Hauts-de-Seine, France
Institut Regional du Cancer de Montpellier - ICM ( Site 0443), Montpellier, Herault, France
Institut De Cancerologie De L Ouest ( Site 0448), Saint Herblain, Loire-Atlantique, France
Centre Hospitalier Regional du Orleans ( Site 0430), Orleans, Loiret, France
Centre D Oncologie de Gentilly ( Site 0432), Nancy, Meurthe-et-Moselle, France
Centre Hospitalier de Valenciennes ( Site 0439), Valenciennes, Nord, France
C.H.U. Lyon Sud ( Site 0436), Pierre Benite, Rhone, France
CHU Amiens Picardie Site Sud Amiens ( Site 0438), Amiens, Somme, France
Institut Gustave Roussy ( Site 0416), Villejuif, Val-de-Marne, France
Institut Sainte Catherine ( Site 0447), Avignon, Vaucluse, France
Institut Mutualiste Montsouris ( Site 0446), Paris, , France
Universitaetsklinikum Freiburg - Medizinische Klinik ( Site 0304), Freiburg, Baden-Wurttemberg, Germany
Studienpraxis Urologie ( Site 0309), Nuertingen, Baden-Wurttemberg, Germany
Universitaetsklinik fuer Urologie ( Site 0307), Tuebingen, Baden-Wurttemberg, Germany
Klinikum Rechts der Isar ( Site 0300), Muenchen, Bayern, Germany
Universitaetsklinik der Paracelsus Medizinischen Privatuniversitaet ( Site 0318), Nuernberg, Bayern, Germany
Universitaetsklinikum Goettingen ( Site 0345), Goettingen, Niedersachsen, Germany
Uniklinik RWTH Aachen ( Site 0308), Aachen, Nordrhein-Westfalen, Germany
Universitaetsklinikum Muenster ( Site 0320), Muenster, Nordrhein-Westfalen, Germany
Krankenhaus der Barmherzigen Brueder Trier ( Site 0310), Trier, Rheinland-Pfalz, Germany
Universitaetsklinikum des Saarlandes ( Site 0348), Homburg, Saarland, Germany
Universitaetsklinikum Schleswig Holstein. ( Site 0346), Luebeck, Schleswig-Holstein, Germany
Universitaetsklinikum Jena ( Site 0305), Jena, Thuringen, Germany
Charite Universitaetsmedizin Berlin ( Site 0301), Berlin, , Germany
Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 1321), Kecskemét, Bacs-Kiskun, Hungary
Petz Aladár Megyei Oktató Kórház-Onkológiai Osztály ( Site 1324), Gyor, Gyor-Moson-Sopron, Hungary
Országos Onkológiai Intézet-Urogenital Tumors Department and Clinical Pharmacology ( Site 1325), Budapest, Pest, Hungary
Magyar Honvedseg Egeszsegugyi Kozpont-Onkologiai Osztaly ( Site 1326), Budapest, , Hungary
Beaumont Hospital ( Site 0726), Dublin, , Ireland
Tallaght University Hospital ( Site 0730), Dublin, , Ireland
Mid Western Cancer Centre ( Site 0728), Limerick, , Ireland
HaEmek Medical Center ( Site 0548), Afula, , Israel
Assuta Ashdod Medical Center ( Site 0550), Ashdod, , Israel
Soroka Medical Center ( Site 0549), Beer Sheva, , Israel
Rambam Health Care Campus-Oncology Division ( Site 0543), Haifa, , Israel
Hadassah Ein Kerem Medical Center ( Site 0546), Jerusalem, , Israel
Meir Medical Center ( Site 0544), Kfar Saba, , Israel
Rabin Medical Center ( Site 0545), Petach-Tikwa, , Israel
Chaim Sheba Medical Center ( Site 0541), Ramat Gan, , Israel
Sourasky Medical Center ( Site 0542), Tel Aviv, , Israel
Yitzhak Shamir Medical Center ( Site 0547), Zerifin, , Israel
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori-Oncologia Medica ( Site 0464), Meldola, Emilia-Romagna, Italy
Istituto Clinico Humanitas Research Hospital ( Site 0452), Rozzano, Lombardia, Italy
Presidio Ospedaliero S. Maria Delle Grazie-U.O.C. ONCOLOGIA ( Site 0802), Pozzuoli, Napoli, Italy
Centro Di Riferimento Oncologico ( Site 0800), Aviano, Pordenone, Italy
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Roma-Oncology Unit ( Site 0465), Verona, Veneto, Italy
Medical Oncology Ospedale San Donato ( Site 0461), Arezzo, , Italy
Ospedale Policlinico S. Orsola-Malpighi ( Site 0453), Bologna, , Italy
Azienda Ospedaliera Cannizzaro ( Site 0458), Catania, , Italy
A.O. Universitaria di Modena ( Site 0454), Modena, , Italy
Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 0462), Napoli, , Italy
Azienda Ospedaliera San Camillo Forlanini ( Site 0455), Roma, , Italy
Fondazione Policlinico Universitario Agostino Gemelli ( Site 0801), Roma, , Italy
Azienda Ospedaliera Santa Maria Terni ( Site 0456), Terni, , Italy
Az. Osp. Univ. Sta Maria della Misericordia di Udine ( Site 0460), Udine, , Italy
National Cancer Center Hospital East ( Site 0702), Kashiwa, Chiba, Japan
Toho University Sakura Medical Center ( Site 0703), Sakura, Chiba, Japan
National Hospital Organization Shikoku Cancer Center ( Site 0716), Matsuyama, Ehime, Japan
Iizuka Hospital ( Site 0744), Iizuka, Fukuoka, Japan
Hakodate Goryoukaku Hospital ( Site 0739), Hakodate, Hokkaido, Japan
Kanazawa University Hospital ( Site 0701), Kanazawa, Ishikawa, Japan
Kitasato University Hospital ( Site 0705), Sagamihara, Kanagawa, Japan
Yokohama City University Medical Center ( Site 0706), Yokohama, Kanagawa, Japan
Miyagi Cancer Center ( Site 0747), Natori, Miyagi, Japan
Nara Medical University Hospital ( Site 0715), Kashihara, Nara, Japan
Kindai University Hospital ( Site 0714), Osakasayama, Osaka, Japan
Osaka University Hospital ( Site 0713), Suita, Osaka, Japan
Saitama Medical University International Medical Center ( Site 0708), Hidaka, Saitama, Japan
Saitama Medical Center ( Site 0743), Kawagoe, Saitama, Japan
Dokkyo Medical University Saitama Medical Center ( Site 0707), Koshigaya, Saitama, Japan
Hamamatsu University Hospital ( Site 0720), Hamamatsu, Shizuoka, Japan
Yamaguchi University Hospital ( Site 0717), Ube, Yamaguchi, Japan
Chiba Cancer Center ( Site 0704), Chiba, , Japan
Kyushu University Hospital ( Site 0718), Fukuoka, , Japan
Hiroshima Prefectural Hospital ( Site 0748), Hiroshima, , Japan
University of Miyazaki Hospital ( Site 0721), Miyazaki, , Japan
Nagasaki University Hospital ( Site 0719), Nagasaki, , Japan
Toranomon Hospital ( Site 0711), Tokyo, , Japan
Nippon Medical School Hospital ( Site 0709), Tokyo, , Japan
Keio University Hospital ( Site 0710), Tokyo, , Japan
National Cancer Center ( Site 0174), Goyang-si, Kyonggi-do, Korea, Republic of
Seoul National University Bundang Hospital ( Site 0175), Seongnam-si, Kyonggi-do, Korea, Republic of
Asan Medical Center ( Site 0176), Songpagu, Seoul, Korea, Republic of
Seoul National University Hospital ( Site 0171), Seoul, , Korea, Republic of
Samsung Medical Center ( Site 0172), Seoul, , Korea, Republic of
Radboud University Medical Center ( Site 0470), Nijmegen, Gelderland, Netherlands
Maastricht University Medical Centre ( Site 0467), Maastricht, Limburg, Netherlands
Amphia Hospital Location Molengracht ( Site 0474), Breda, Noord-Brabant, Netherlands
Catharina Ziekenhuis ( Site 0472), Eindhoven, Noord-Brabant, Netherlands
Noordwest Ziekenhuisgroep NWZ ( Site 0468), Alkmaar, Noord-Holland, Netherlands
Vrije Universiteit Medisch Centrum ( Site 0479), Amsterdam, Noord-Holland, Netherlands
Tergooiziekenhuizen ( Site 0466), Hilversum, Noord-Holland, Netherlands
Spaarne Ziekenhuis ( Site 0473), Hoofddorp, Noord-Holland, Netherlands
Ziekenhuisgroep Twente ( Site 0469), Hengelo, Overijssel, Netherlands
Haaglanden MC - locatie Antoniushove ( Site 0471), Leidschendam, Zuid-Holland, Netherlands
Franciscus Gasthuis en Vlietland ( Site 0489), Schiedam, Zuid-Holland, Netherlands
Tauranga Hospital ( Site 0215), Tauranga, Bay Of Plenty, New Zealand
Canterbury Regional Cancer & Blood Service ( Site 0195), Christchurch, Canterbury, New Zealand
Auckland City Hospital ( Site 0193), Auckland, , New Zealand
Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 0636), Bydgoszcz, Kujawsko-pomorskie, Poland
Salve Medica SP ( Site 0686), Lodz, Lodzkie, Poland
Provita Prolife Centrum Medyczne ( Site 0630), Tomaszow Mazowiecki, Lodzkie, Poland
Clinical Best Solutions ( Site 0622), Warszawa, Mazowieckie, Poland
Przychodnia Lekarska Komed ( Site 0628), Konin, Wielkopolskie, Poland
Szpital Wojewodzki im. Mikolaja Kopernika ( Site 0624), Koszalin, Zachodniopomorskie, Poland
Puerto Rico Medical Research Center LLC ( Site 1122), San Juan, , Puerto Rico
Fundacion de Investigacion de Diego ( Site 1121), San Juan, , Puerto Rico
Chelyabinsk Regional Clinical Oncological Dispensary ( Site 0565), Chelyabinsk, Chelyabinskaya Oblast, Russian Federation
Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0585), Krasnoyarsk, Krasnoyarskiy Kray, Russian Federation
Russian Scientific Center of Roentgenoradiology ( Site 0559), Moscow, Moskva, Russian Federation
Central Clinical Hospital with Polyclinic ( Site 0562), Moscow, Moskva, Russian Federation
Omsk Clinical Oncology Dispensary ( Site 0568), Omsk, Omskaya Oblast, Russian Federation
SBHI Samara Regional Clinical Oncology Dispensary ( Site 0576), Samara, Samarskaya Oblast, Russian Federation
SBHI Leningrad Regional Oncology Dispensary ( Site 0588), Saint Petersburg, Sankt-Peterburg, Russian Federation
Clinical Research Center of specialized types medical care-Oncology ( Site 0570), Saint Petersburg, Sankt-Peterburg, Russian Federation
Russian Scientific Center of Radiology and Surgical Technologies ( Site 0567), Saint Petersburg, Sankt-Peterburg, Russian Federation
Tomsk National Scientific Medical Center of Russian Academy of Science ( Site 0579), Tomsk, Tomskaya Oblast, Russian Federation
Instituto Catalan de Oncologia - ICO ( Site 0330), L Hospitalet De Llobregat, Barcelona, Spain
Hospital Parc Tauli ( Site 0335), Sabadell, Barcelona, Spain
Hospital Josep Trueta ( Site 0321), Girona, Gerona, Spain
Hospital Quiron Madrid ( Site 0325), Pozuelo de Alarcon, Madrid, Spain
Instituto Valenciano de Oncologia ( Site 0331), Valencia, Valenciana, Comunitat, Spain
Hospital del Mar ( Site 0333), Barcelona, , Spain
Hospital Provincial San Pedro Alcantara ( Site 0326), Caceres, , Spain
Hospital Universitario Gregorio Maranon ( Site 0327), Madrid, , Spain
MD Anderson Cancer Center Madrid ( Site 0332), Madrid, , Spain
Hospital Clinico San Carlos ( Site 0324), Madrid, , Spain
Hospital Universitario HM Sanchinarro ( Site 0322), Madrid, , Spain
Hospital Universitario Virgen de la Victoria ( Site 0337), Malaga, , Spain
Hospital Virgen del Rocio ( Site 0329), Sevilla, , Spain
National Cheng Kung University Hospital ( Site 0134), Tainen, Tainan, Taiwan
China Medical University Hospital ( Site 0132), Taichung, , Taiwan
Taichung Veterans General Hospital ( Site 0133), Taichung, , Taiwan
National Taiwan University Hospital ( Site 0131), Taipei, , Taiwan
Taipei Veterans General Hospital ( Site 0135), Taipei, , Taiwan
Ege University Medicine of Faculty ( Site 0661), Bornova, Izmir, Turkey
Baskent University Dr. Turgut Noyan Research and Training Center-ONCCOLOGY ( Site 0618), Adana, , Turkey
Ankara University Hospital Cebeci ( Site 0613), Ankara, , Turkey
Hacettepe Universitesi-oncology hospital ( Site 0615), Ankara, , Turkey
Ankara City Hospital-Medical Oncology ( Site 0616), Ankara, , Turkey
T.C. Saglik Bakanligi Turkiye Kamu Hastaneleri Kurumu - Baki-Istanbul Bakirkoy Sadi Konuk Training (, Istanbul, , Turkey
Acıbadem Maslak Hastanesi ( Site 0660), İstanbul, , Turkey
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 0619), Istanbul, , Turkey
Cherkasy Regional Oncology Dispensary ( Site 1203), Cherkassy, Cherkaska Oblast, Ukraine
Dnepropetrovsk Regional Clinical Oncology Hospital-Clinical oncological dispensary ( Site 1201), Dnipropetrovsk, Dnipropetrovska Oblast, Ukraine
Dnepropetrovsk Regional Clinical Hospital Mechnikov-Department of urology ( Site 1205), Dnipro, Dnipropetrovska Oblast, Ukraine
Ivano-Frankivsk Regional Hospital-Urology department ( Site 1208), Ivano-Frankivsk, Ivano-Frankivska Oblast, Ukraine
Communal Non-Commercial Enterprise ""Prykarpatski Clinical Oncological Center"" of Ivano-Frankivsk R, Ivano-Frankivsk, Ivano-Frankivska Oblast, Ukraine
CNPE Regional Center of Oncology-oncourology department ( Site 1202), Kharkiv, Kharkivska Oblast, Ukraine
LISOD - Israeli Oncological Hospital ""MedX-ray Internationa-Department of Clinical and Scientific (, Kiev, Kyivska Oblast, Ukraine
Municipal non-profit enterprise Kyiv City Clinical Oncology -Oncourology department ( Site 1204), Kyiv, Kyivska Oblast, Ukraine
University Hospitals Bristol NHS Foundation Trust ( Site 0530), Bristol, Bristol, City Of, United Kingdom
Cambridge University Hospitals NHS Trust ( Site 0540), Cambridge, Cambridgeshire, United Kingdom
Torbay Hospital ( Site 0532), Torquay, Devon, United Kingdom
University College London Hospitals NHS Foundation Trust ( Site 0482), London, London, City Of, United Kingdom
Musgrove Park Hospital ( Site 0537), Taunton, Somerset, United Kingdom
Royal Marsden Hospital (Sutton) ( Site 0526), London, Sutton, United Kingdom
Western General Hospital ( Site 0531), Edinburgh, Worcestershire, United Kingdom
Mount Vernon Cancer Centre ( Site 0536), Northwood, , United Kingdom
Contact Details
Name: Medical Director
Affiliation: Merck Sharp & Dohme LLC
Role: STUDY_DIRECTOR
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