Spots Global Cancer Trial Database for Peritoneal Surface Malignancies - Characterization, Models and Treatment Strategies

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Trial Identification

Brief Title: Peritoneal Surface Malignancies - Characterization, Models and Treatment Strategies

Official Title: Prospective Observational Study of Peritoneal Surface Malignancies (PSM) - Characterization, Models and Treatment Strategies.

Study ID: NCT02073500

Conditions

Pseudomyxoma Peritonei

Colorectal Carcinoma

Ovarian Carcinoma

Mesothelioma

Interventions

Observational study.

Study Description

Brief Summary: The aim of this study is to identify biomarkers of disease recurrence and prognosis to optimize patient selection for treatment with cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC), and through animal models to explore different treatment strategies for peritoneal surface malignancies (PSM).

Detailed Description: The handling of patients with PSM involves multimodal and multidisciplinary treatment strategies such as CRS, the removal of all macroscopically detectable tumor, and HIPEC, instillation of heated chemotherapy in the abdominal cavity to remove residual cancer disease. The treatment is challenging and complex and associated with significant morbidity. Only patients with limited disease will benefit from the treatment, and better methods for patient selection are needed. The project group has a unique opportunity to address key questions because of acquired experience, an exceptional biobank and institutional database and novel animal models established at the Norwegian Radium Hospital.