Spots Global Cancer Trial Database for Re-irradiation for Pelvic Recurrences in Rectal Cancer Patients

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Trial Identification

Brief Title: Re-irradiation for Pelvic Recurrences in Rectal Cancer Patients

Official Title: External Beam Radiotherapy for Pelvic Recurrences in Rectal Cancer Patients Previously Treated With Radiotherapy

Study ID: NCT05816980

Conditions

Rectal Cancer

Recurrence

Radiation Toxicity

Interventions

Hyperfractionated external beam radiation

Study Description

Brief Summary: This study investigates the potential benefit of re-irradiation of patients with locally advanced rectal recurrences, by a prospective phase II clinical, imaging and translational research study.

Detailed Description: The overall purpose of this trial is to evaluate the efficacy of re-irradiation of patients with locally advanced rectal cancer (LRRC) recurrences who previously received pelvic irradiation. Patients with potentially resectable LRRC will be treated with hyperfractionated Intensity-Modulated Radiotherapy consisting of 40.8 Gy in 1.2 fractions twice daily with concomitant oral capecitabine followed by surgery, when feasible.