The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
Brief Title: Total Neoadjuvant Therapy With mFOLFOX and Short-course Radiation in Resectable Rectal Cancer
Official Title: Phase 2 Study of Total Neoadjuvant mFOLFOX and Short-Course Radiotherapy in Resectable Rectal Cancer
Study ID: NCT04643366
Brief Summary: This is phase 2 trial of neoadjuvant therapy and short-course radiotherapy in resectable rectal cancer.
Detailed Description: This trial involves 4 cycles of systemic chemotherapy followed by short-course RT with concurrent 5-FU neoadjuvant chemoradiotherapy (CRT) and subsequent consolidation with 4 cycles of systemic chemotherapy prior to surgery or, for those who achieve cCR, the option of non-operative active surveillance.Three-year disease free survival (DFS) defined as the percentage of patients alive without recurrence of disease at 3 years measured from the date of clinical complete response (cCR) or date of total mesorectal excision (TME) at surgery (whichever is earlier).
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Virginia Cancer Institute, Richmond, Virginia, United States
Virginia Commonwealth University Massey Cancer Center, Richmond, Virginia, United States
VCU Community Memorial Healthcenter, South Hill, Virginia, United States
Name: Khalid Matin, MD
Affiliation: Massey Cancer Center
Role: PRINCIPAL_INVESTIGATOR