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Brief Title: Trial Evaluating the Tailored Versus the Systematic Use of Defunctioning Stoma After Total Mesorectal Excision for Rectal Cancer (GRECCAR17)
Official Title: A Phase III Randomized Trial Evaluating the Tailored Versus the Systematic Use of Defunctioning Stoma After Total Mesorectal Excision for Rectal Cancer
Study ID: NCT05233787
Brief Summary: GRECCAR 17 will be the first prospective and randomized trial to assess a tailored policy in the use of defunctioning stoma after TME according to the personalized risk of anastomotic leakage. The tailored use of defunctioning stoma after TME for rectal cancer should improve both the quality of life of patients and the anorectal function, without any impact on anastomotic leakage. Moreover, for the healthcare system, this new approach could be a cost-effective strategy, leading to a decrease in healthcare expenses. The main objective is to compare the impact of tailored defunctioning stoma after TME for rectal cancer versus the systematic use of defunctioning stoma on the evolution of the specific Quality Of Life (QLQC30) during the 12 months after surgery.
Detailed Description: The introduction of Total Mesorectal Excision (TME) as the surgical procedure of choice for low and mid rectal cancer has led to decrease local recurrence and improved oncological results. Postoperative morbidity remains a major issue, and the most feared complication is anastomotic leakage. The systematic use of a defunctioning stoma during 3 months to protect low colorectal anastomosis (below than 7 cm from the anal verge) is the standard of practice after TME surgery in order to decrease risks of anastomotic leakage and urgent re-operations. However, there have been a lot of controversies surrounding the role of defunctioning stoma mainly due to stoma-related complications, ranked from 20% to 60%, which may lead to prolonged inpatient care, urgent re-operation and devastating effects on quality of life (QOL) and healthcare expenses. Moreover, it has been reported that patients either without defunctioning stoma, or with early stoma closure (days 8-12 after TME) have a better functional outcomes than patients with systematic defunctioning stoma for 3 months. The experimental arm (arm A) will benefit from a tailored use of defunctioning stoma after TME based on a 2-step process: i) to perform or not a defunctioning stoma according to the personalized risk of anastomotic leakage (defunctioning stoma only if Anastomotic Failure Observed Risk Score=\[2-6\]), ii) to perform an early stoma closure at day 8-12, according to clinical (fever), biological (CRP level days 2 and 4 postoperatively) and radiological postoperative assessment (CT-scan with colonic contrast retrograde enema day 7-8 postoperatively). The control arm (arm B) will benefit from systematic use of defunctioning stoma for 2-3 months after TME, according to French national and international guidelines. Patients will be followed at 1, 4, 8 and 12 months after surgery, with chest, abdominal and pelvic scan and tumour markers.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
CHU Amiens-Picardie - Service de Chirurgie Digestive, Amiens, , France
CHRU de Besançon - Service de Chirurgie Générale, Digestive et Cancérologique - Unité de Transplantation Hépatique, Besançon, , France
CHU de Bordeaux - Service de Chirurgie Digestive et Endocrinienne - Unité Colorectale, Bordeaux, , France
Clinique Tivoli Ducos - Service de Chirurgie Digestive, Bordeaux, , France
CHU de Clermont-Ferrand - Service de Chirurgie Digestive et Hépato-biliaire, Clermont-Ferrand, , France
APHP - Hôpital Beaujon - Service de Chirurgie Digestive, Clichy, , France
CHU Grenoble Alpes - Service de Chirurgie Digestive, La Tronche, , France
APHP - Hôpital Bicêtre - Service de Chirurgie Générale et Digestive, Le Kremlin-Bicêtre, , France
CHU de Lille - Service de Chirurgie Générale et Digestive, Lille, , France
Centre Lyonnais de Chirurgie Digestive, Lyon, , France
APHM - Hôpital La Timone - Service de Chirurgie Digestive et Générale, Marseille, , France
APHM - Hôpital Nord - Service de Chirurgie Digestive, Marseille, , France
Hôpital Européen de Marseille - Service de Chirurgie Digestive, Marseille, , France
Institut Paoli Calmette - Service de Chirurgie Digestive, Marseille, , France
Institut du Cancer de Montpellier - Service de Chirurgie Digestive, Montpellier, , France
APHP - HEGP- Service de Chirurgie Digestive, Paris, , France
APHP - Hôpital Saint Antoine - Service de Chirurgie Digestive, Paris, , France
APHP - Hôpital Saint-Louis - Service de Chirurgie Viscérale, Cancérologique et Endocrinienne, Paris, , France
GH Diaconesses Croix Saint-Simon - Service de Chirurgie Digestive, Paris, , France
Groupe Hospitalier Paris St. Joseph - Service de Chirurgie Digestive et Obésité, Paris, , France
Hospices Civils de Lyon - Sevice de Chirurgie Digestive, Pierre-Bénite, , France
CHU de Rennes - Service de Chirurgie Hépatobiliaire et Digestive, Rennes, , France
CHU de Rouen - Service de Chirugie Digestive, Rouen, , France
CHRU de Strasbourg - Service de Chirurgie Générale et, Strasbourg, , France
CHU de Toulouse - Service de Chirurgie Digestive, Toulouse, , France
CHRU de Tours - Service de Chirurgie Digestive Oncologique et Colorectale, Tours, , France
CHRU de Nancy - Service de Chirugie Digestive, Hépatobiliaire, endocrinienne et Cancérologique, Vandœuvre-lès-Nancy, , France
Institut Gustave Roussy - Service de Chirurgie Viscérale Oncologique, Villejuif, , France
Name: Christophe LAURENT
Affiliation: University Hospital, Bordeaux
Role: PRINCIPAL_INVESTIGATOR