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Brief Title: Niraparib in Combination With Dostarlimab in Patients With Recurrent or Progressive Cervix Cancer
Official Title: Phase II Trial of Niraparib in Combination With Dostarlimab in Patients With Recurrent or Progressive Cervix Cancer (OU-SCC-STAR)
Study ID: NCT04068753
Brief Summary: The purpose of this research study is to test the safety of Niraparib and dostarlimab as a combination treatment and see what effects (good and bad) this combination treatment has on patients with recurrent or progressive cervix cancer.
Detailed Description: Patients will have tests and exams to see if they are eligible for the clinical trial. If found eligible, the patient will receive treatment with Niraparib daily and dostarlimab by vein every three weeks for 4 cycles then every six weeks. Patients will receive the study treatment as long as there is evidence that the tumor is not growing or spreading and they are not having any unacceptable, bad side effects. Patients will be monitored during treatment with tests and exams and after treatment completion for up to 5 years.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana, United States
Louisiana State University Health Science Center, New Orleans, Louisiana, United States
Stephenson Cancer Center, Oklahoma City, Oklahoma, United States
University of Virginia Cancer Center, Charlottesville, Virginia, United States
Name: Debra Richardson, MD
Affiliation: Stephenson Cancer Center
Role: PRINCIPAL_INVESTIGATOR