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Spots Global Cancer Trial Database for Standard Chemotherapy vs. Chemotherapy Guided by Cancer Stem Cell Test in Recurrent Glioblastoma

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Standard Chemotherapy vs. Chemotherapy Guided by Cancer Stem Cell Test in Recurrent Glioblastoma

Official Title: Standard Chemotherapy Versus Chemotherapy Chosen by Cancer Stem Cell Chemosensitivity Testing in the Management of Patients With Recurrent Glioblastoma Multiforme (GBM).

Study ID: NCT03632135

Study Description

Brief Summary: The purpose of this clinical study is to confirm the utility of chemosensitivity tumor testing on cancer stem cells (ChemoID) as a predictor of clinical response in poor prognosis malignant brain tumors such as recurrent glioblastoma (GBM).

Detailed Description: This study is designed as a parallel group randomized controlled clinical trial to determine if recurrent Glioblastoma (GBM) patients treated with drugs predicted by the ChemoID assay will have better outcomes than patients treated with standard-of-care control therapy chosen by the Physician. Upon obtaining informed consent, all eligible participants affected by recurrent GBM will have a tumor biopsy to undergo ChemoID drug response testing with multiple FDA-approved chemotherapeutic agents. Eligible participants will be randomized to a standard treatment arm with control treatment (chemotherapy chosen by the Physician from a provided list), or to a study arm of FDA-approved drugs selected by the ChemoID drug response assay.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Kaiser Permanente, Los Angeles, California, United States

Keck School of Medicine of the University of Southern California, Los Angeles, California, United States

Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States

Maine Medical Center Research Institute, Scarborough, Maine, United States

University of Mississippi Medical Center, Jackson, Mississippi, United States

University of Cincinnati Cancer Institute, Cincinnati, Ohio, United States

Toledo University, Toledo, Ohio, United States

Providence Cancer Center Oncology, Portland, Oregon, United States

St. Luke's University Health Network, Bethlehem, Pennsylvania, United States

The Penn State Univeristy College of Medicine, Hershey, Pennsylvania, United States

Thomas Jefferson University Hospitals, Philadelphia, Pennsylvania, United States

Allegheny Health Network, Pittsburgh, Pennsylvania, United States

Charleston Area Medical Center, Charleston, West Virginia, United States

Contact Details

Name: Tulika Ranjan, MD

Affiliation: Allegheny Health Network

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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