Spots Global Cancer Trial Database for PTCs-based Precision Treatment Strategy on Recurrent High-grade Gliomas

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Trial Identification

Brief Title: PTCs-based Precision Treatment Strategy on Recurrent High-grade Gliomas

Official Title: Study on Precision Treatment Strategy Through PTCs (Patient-derived Tumor-like Cell Clusters)-Based Drug Screening for Recurrent High-grade Gliomas

Study ID: NCT05473923

Conditions

Recurrent High Grade Glioma

Interventions

Receiving chemotherapeutic or targeted drugs recommended by molecular tumor board.

Study Description

Brief Summary: This trial is an open-label, single-arm, phase 0/1 study of high-grade glioma that aims to evaluate the feasibility, preliminary efficacy and safety of the precision treatment strategy.

Detailed Description: The investigators have established a precision treatment strategy, that select chemotherapeutic drugs or targeted drugs based on information from PTCs drug-screening or/and bioinformatic prediction. In this study, the investigators are going to exploit this strategy for the precision treatment of recurrent high-grade gliomas. The investigators will evaluate the feasibility, safety and preliminary efficacy via collecting the indexes comprising clinical presentation, results of imaging examination, clinical assays, KPS, neurological score, etc.