Spots Global Cancer Trial Database for Study of Selinexor in Combination With Backbone Treatments or Novel Therapies In Participants With Relapsed or Refractory (RR) Diffuse Large B-Cell Lymphoma (DLBCL)
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Trial Identification
Brief Title: Study of Selinexor in Combination With Backbone Treatments or Novel Therapies In Participants With Relapsed or Refractory (RR) Diffuse Large B-Cell Lymphoma (DLBCL)
Official Title: A Multicenter, Phase 1/2 Study of Selinexor in Combination With Backbone Treatments or Novel Therapies in Patients With Relapsed or Refractory (RR) Diffuse Large B-Cell Lymphoma (DLBCL)
Study ID: NCT04607772
Study Description
Brief Summary: This is a Phase 1/2, multicenter, open-label study to evaluate the efficacy, and safety of various combinations with selinexor in participants with RR DLBCL. The study will be conducted in two phases: Phase 1 and 2. The Phase 1 of the study will be a standard 3 + 3 dose escalation to determine the maximal tolerated dose (MTD), recommended Phase 2 dose (RP2D) for each treatment arm, and assess the dose limiting toxicities (DLTs). The Phase 2 of the study will be a dose expansion study to assess the efficacy and safety of for RP2D selected at the end of Phase 1 of the study for each treatment arm.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Arizona, Tucson, Arizona, United States
California Cancer Associates for Research and Excellence, Encinitas, California, United States
UC San Diego Moores Cancer Center, La Jolla, California, United States
University of California Irvine, Orange, California, United States
US Oncology - Rocky Mountain Cancer Center, Aurora, Colorado, United States
Loyola University Medical Center, Maywood, Illinois, United States
Mission Cancer + Blood, Des Moines, Iowa, United States
University of Michigan Health System, Ann Arbor, Michigan, United States
Karmanos Cancer Institute, Detroit, Michigan, United States
University of Nebraska Medical Center, Omaha, Nebraska, United States
Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States
US Oncology - Oncology Associates of Oregon, Eugene, Oregon, United States
UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, United States
US Oncology - Prisma Health, Greenville, South Carolina, United States
US Oncology - Texas Oncology Austin Midtown, Austin, Texas, United States
University of Texas Southwestern, Dallas, Texas, United States
Baylor Clinic - Mcnair Center, Houston, Texas, United States
US Oncology - Northwest Cancer Specialists, Vancouver, Washington, United States
Contact Details
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