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Brief Title: Trial of Nelarabine, Etoposide and Cyclophosphamide in Relapsed T-cell ALL and T-cell LL
Official Title: A Phase I Trial of NECTAR (Nelarabine, Etoposide and Cyclophosphamide in T-ALL Relapse): A Joint Study of TACL and POETIC
Study ID: NCT00981799
Brief Summary: Nelarabine has shown significant activity in patients with T-cell malignancies. This study will determine the safety and maximum tolerated dose of the combination of nelarabine, cyclophosphamide and etoposide in patients with first bone marrow relapse of T-ALL, or first relapse of T-LL.
Detailed Description:
Minimum Age: 1 Year
Eligible Ages: CHILD, ADULT
Sex: ALL
Healthy Volunteers: No
Childrens Hospital Los Angeles, Los Angeles, California, United States
Children's Hospital Orange County, Orange, California, United States
UCSF School of Medicine, San Francisco, California, United States
The Children's Hospital, University of Colorado, Aurora, Colorado, United States
Children's National Medical Center, Washington, District of Columbia, United States
University of Miami Cancer Center, Miami, Florida, United States
Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, United States
Lurie Children's Hospital, Chicago, Illinois, United States
Johns Hopkins University, Baltimore, Maryland, United States
Dana Farber, Boston, Massachusetts, United States
C.S. Mott Children's Hospital, Ann Arbor, Michigan, United States
Childrens Hospital & Clinics of Minnesota, Minneapolis, Minnesota, United States
Children's Mercy Hospitals and Clinics, Kansas City, Missouri, United States
New York University Medical Center, New York, New York, United States
Children's Hospital New York-Presbyterian, New York, New York, United States
Levine Children's Hospital at Carolinas Medical Center, Charlotte, North Carolina, United States
Rainbow Babies, Cleveland, Ohio, United States
Nationwide Childrens Hospital, Columbus, Ohio, United States
Oregon Health and Science University, Portland, Oregon, United States
St. Jude, Memphis, Tennessee, United States
Vanderbilt Children's Hospital, Nashville, Tennessee, United States
University of Texas at Southwestern, Dallas, Texas, United States
Cook Children's Hospital, Fort Worth, Texas, United States
Primary Children's, Salt Lake City, Utah, United States
Seattle Children's Hospital, Seattle, Washington, United States
Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Children's Hospital at Westmead, Westmead, New South Wales, Australia
Royal Children's Hospital, Brisbane, Queensland, Australia
Royal Children's Hospital, Melbourne, Melbourne, Victoria, Australia
Sydney Children's Hospital, Sydney, , Australia
St. Anna Children's Hospital, Vienna, , Austria
Hospital for Sick Kids, Toronto, Ontario, Canada
Sainte Justine University Hospital, Montreal, Quebec, Canada
British Columbia Children's Hospital, Vancouver, , Canada
CHU Lille, Lille, , France
Bambino Gesù Hospital, Rome, , Italy
Erasmus MC - Sophia, Rotterdam, , Netherlands
Name: Jim Whitlock, MD
Affiliation: The Hospital for Sick Children
Role: STUDY_CHAIR