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Spots Global Cancer Trial Database for CLARA: Somatic and Germline Mechanisms That Impact Renal Cancer Immunotherapy

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Trial Identification

Brief Title: CLARA: Somatic and Germline Mechanisms That Impact Renal Cancer Immunotherapy

Official Title: CLARA: Characterization of Somatic and Germline Mechanisms That Impact the Immunotherapy Treatment and Prognosis of Patients With Renal Cancer

Study ID: NCT05215470

Interventions

Nivolumab
Ipilimumab

Study Description

Brief Summary: The study is studying the joint contribution and interactions of germline variants and somatic mutations and their impact on Renal Cell Carcinoma (RCC) development and treatment (immunotherapy).

Detailed Description: One hundred newly diagnosticated stage IV RCC patients will be recruited in the Ribeirao Preto Medical School. Patients will be treated with immune checkpoint inhibitors (ICI) combination: nivolumab (3 mg/kg of body weight) plus ipilimumab (1 mg/kg) intravenously every three weeks for four doses, followed by nivolumab 480mg every four weeks, until progression, toxicity or complete two years of treatment. Patients will be followed up for the clinical outcome (progression-free survival, best response, and overall survival). Fresh-frozen primary tumor tissue will be collected for somatic genomic characterization. Blood DNA will be genotyped for the identification of common germline variation, as well as ancestry determination.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Hospital das Clínicas da Faculdade de Medicina de Ribeirao Preto - USP, Ribeirão Preto, Sao Paulo, Brazil

Contact Details

Name: Leandro Machado Colli, MD, PhD

Affiliation: University of Sao Paulo

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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