Spots Global Cancer Trial Database for molecular profiling
Every month we try and update this database with for molecular profiling cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| Clinico-biological Study/Characterization of Rhabdomyosarcoma in Adolescents and Young Adults, 15-25-year-old Patients | NCT03462888 | Rhabdomyosarcom... | 15 Years - 25 Years | Centre Oscar Lambret | ||
| PRecISion Medicine for Children With Cancer | NCT03336931 | Childhood Cance... Childhood Solid... Childhood Brain... Childhood Leuke... Refractory Canc... Relapsed Cancer | Molecular profi... | - 21 Years | Sydney Children's Hospitals Network | |
| Primary Chemotherapy With Docetaxel-Capecitabine and Doxorubicin-Cyclophosphamide in Breast Cancer | NCT00005908 | Breast Cancer Breast Neoplasm | Docetaxel - Dos... Anastrozole cyclophosphamid... Docetaxel - Dos... Doxorubicin hyd... Tamoxifen Citra... Capecitabine - ... Capecitabine - ... | 18 Years - | National Institutes of Health Clinical Center (CC) | |
| Frequency of EGFR Mutations in Latinos/Hispanics With Non-Small Cell Lung Cancer | NCT01255150 | Non-Small-Cell ... | 2 Years - 100 Years | National Institutes of Health Clinical Center (CC) | ||
| Personalized Patient Derived Xenograft (pPDX) Modeling to Test Drug Response in Matching Host | NCT02732860 | Colorectal Neop... Colorectal Canc... Breast Cancer Breast Neoplasm... Ovarian Cancer Ovarian Neoplas... | Molecular Profi... | 18 Years - | University Health Network, Toronto | |
| Study of Changes and Characteristics of Genes in Patients With Pancreatic Cancer for Better Treatment Selection | NCT02750657 | Carcinoma, Panc... | Molecular Profi... | 18 Years - | University Health Network, Toronto | |
| Precision Medicine for Every Child With Cancer | NCT05504772 | Childhood Cance... Childhood Solid... Childhood Brain... Childhood Leuke... Refractory Canc... Relapsed Cancer | Whole Genome Se... RNA seq DNA Methylation Targeted Panel ... High Throughput... Patient Derived... Liquid Biopsy | 0 Years - 25 Years | Australian & New Zealand Children's Haematology/Oncology Group | |
| Immune Resistance Interrogation Study | NCT04243720 | Cancer Solid Tumor Metastatic Canc... Immune Resistan... | 18 Years - | University Health Network, Toronto | ||
| Study of Changes and Characteristics of Genes in Patients With Pancreatic Cancer for Better Treatment Selection | NCT02750657 | Carcinoma, Panc... | Molecular Profi... | 18 Years - | University Health Network, Toronto | |
| Non-Invasive Artificial Intelligence-Based Platform MonIToring Program (NIP IT!) | NCT05196087 | Breast Cancer Melanoma Gastrointestina... | 18 Years - | University Health Network, Toronto | ||
| Pancreas Cancer: Molecular Profiling as a Guide to Therapy Before and After Surgery ("Personalized Medicine") | NCT01726582 | Pancreatic Aden... | Milestone 1: Ta... Milestone 2: Ch... Milestone 3: Ta... Milestone 3: Ch... Milestone 4: st... Milestone 4: Ch... Milestone 5: Ta... Milestone 5: Ch... Milestone 6: Ge... Milestone 6: Ch... Milestone 7: Ch... Milestone 8: Ta... Milestone 9: Ge... Milestone 10: N... | 18 Years - | Medical College of Wisconsin | |
| Molecular Profiling and Targeted Therapy for Advanced Non-Small Cell Lung Cancer, Small Cell Lung Cancer, and Thymic Malignancies | NCT01306045 | Carcinoma, Non-... Carcinoma, Smal... Carcinoma, Thym... | AZD6244 MK-2206 Lapatinib Erlotinib Sunitinib Molecular Profi... | 18 Years - | National Institutes of Health Clinical Center (CC) | |
| POA Retrospective Repository | NCT03326479 | Oncology Solid Tumor, Ad... | Caris Molecular... | 18 Years - | Caris Science, Inc. | |
| CLARA: Somatic and Germline Mechanisms That Impact Renal Cancer Immunotherapy | NCT05215470 | Renal Cancer Me... | Nivolumab Ipilimumab | 18 Years - | Hospital das Clínicas de Ribeirão Preto | |
| Rational Therapeutics Based on Matched Tumor and Normal Tissue | NCT02272595 | Advanced Cancer... | Treatment Based... Treatment Based... | 18 Years - | M.D. Anderson Cancer Center | |
| Sweden Cancerome Analysis Network - Breast Recurrence (SCAN-B-rec) | NCT03758976 | Metastatic Brea... | Biopsies, blood | 18 Years - | Lund University Hospital | |
| Construction and Use of Lung Tumor Microarray for the Analysis of Gene Expression in Lung Cancer | NCT00340847 | Lung Cancer | - | National Institutes of Health Clinical Center (CC) | ||
| Integrated Molecular Profiling in Advanced Cancers Trial | NCT01505400 | Breast Cancer Non-small Cell ... Colorectal Canc... Genitourinary C... Pancreatobiliar... Upper Aerodiges... Gynecological C... Melanoma Cancer... Rare Cancers Unknown Primary... | 18 Years - | University Health Network, Toronto | ||
| Profile Related Evidence to Determine Individualized Cancer Therapy (PREDICT) Program in Advanced Cancer Patients | NCT02160366 | Advanced Cancer... | Biomarker Resea... | - | M.D. Anderson Cancer Center | |
| Rational Therapeutics Based on Matched Tumor and Normal Tissue | NCT02272595 | Advanced Cancer... | Treatment Based... Treatment Based... | 18 Years - | M.D. Anderson Cancer Center | |
| Bergonie Institut Profiling : Fighting Cancer by Matching Molecular Alterations and Drugs in Early Phase Trials | NCT02534649 | Solid Tumor Hematological M... | Newly obtained ... | 18 Years - | Institut Bergonié | |
| Pembrolizumab With Olaparib as Combined Therapy in Metastatic Pancreatic Cancer | NCT05093231 | Pancreatic Canc... | Pembrolizumab Olaparib | 18 Years - | Cambridge University Hospitals NHS Foundation Trust | |
| Real-time Detection of ctDNA and/or HPV DNA in High-risk Locally-advanced Head and Neck Squamous Cell Carcinoma | NCT04599309 | Cancer Head and Neck S... Head and Neck C... | 18 Years - | University Health Network, Toronto | ||
| Prospective Comprehensive Molecular Profiling In Neuroendocrine Tumors | NCT02586844 | Neuroendocrine ... Pancreatic Neur... | 18 Years - | University Health Network, Toronto | ||
| Ontario-wide Cancer TArgeted Nucleic Acid Evaluation | NCT02906943 | Breast Cancer Lung Cancer Colorectal Canc... Melanoma Gynecological C... Genitourinary C... Pancreatobiliar... Gastrointestina... Head and Neck C... Rare Cancer Unknown Primary... | 18 Years - | University Health Network, Toronto | ||
| IMAGE Study: Personalized Molecular Profiling in Cancer Treatment at Johns Hopkins | NCT01939847 | Metastatic Brea... | Treatment sugge... | 18 Years - | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | |
| Prospective Comprehensive Molecular Profiling In Neuroendocrine Tumors | NCT02586844 | Neuroendocrine ... Pancreatic Neur... | 18 Years - | University Health Network, Toronto | ||
| The Screening Protocol for The VIKTORY Trial | NCT02299648 | Stomach Neoplas... | Molecular profi... | 18 Years - | Samsung Medical Center | |
| Pancreatic Cancer Adaptive Neoadjuvant Chemotherapy Trial | NCT03322995 | Pancreatic Canc... | First-line Chem... Second-line Che... Chemoradiation | 18 Years - | Medical College of Wisconsin | |
| A Randomised Evaluation of Molecular Guided Therapy for Diffuse Large B-cell Lymphoma With Bortezomib | NCT01324596 | Lymphoma, Large... | Intravenous Bortezomib | 18 Years - | University Hospital Southampton NHS Foundation Trust | |
| Non-Invasive Artificial Intelligence-Based Platform MonIToring Program (NIP IT!) | NCT05196087 | Breast Cancer Melanoma Gastrointestina... | 18 Years - | University Health Network, Toronto | ||
| Prospective Evaluation and Molecular Profiling in People With Gastric Tumors | NCT03027427 | Stomach Neoplas... Stomach Cancer | 2 Years - | National Institutes of Health Clinical Center (CC) | ||
| Bergonie Institut Profiling : Fighting Cancer by Matching Molecular Alterations and Drugs in Early Phase Trials | NCT02534649 | Solid Tumor Hematological M... | Newly obtained ... | 18 Years - | Institut Bergonié | |
| Feasibility of a Molecular Characterisation Approach to Treatment | NCT02112357 | Advanced Gastro... | 18 Years - | Royal Marsden NHS Foundation Trust | ||
| POA Prospective Repository | NCT03324841 | Solid Tumor, Ad... Oncology | Caris MI Profil... | 18 Years - | Caris Science, Inc. | |
| A Pilot Study Utilizing Proteomic and Genomic Profiling for Patients With Metastatic Breast Cancer | NCT01919749 | Metastatic Brea... | treated recomme... | 18 Years - | Translational Drug Development | |
| Deep sequencIng in Cutaneous Squamous CEll caRciNomas | NCT05878288 | Cutaneous Squam... Cutaneous Squam... Neoplasms Non-melanoma Sk... | Cemiplimab | 18 Years - | Peter MacCallum Cancer Centre, Australia | |
| Precision Medicine for Every Child With Cancer | NCT05504772 | Childhood Cance... Childhood Solid... Childhood Brain... Childhood Leuke... Refractory Canc... Relapsed Cancer | Whole Genome Se... RNA seq DNA Methylation Targeted Panel ... High Throughput... Patient Derived... Liquid Biopsy | 0 Years - 25 Years | Australian & New Zealand Children's Haematology/Oncology Group | |
| The Screening Protocol for The VIKTORY Trial | NCT02299648 | Stomach Neoplas... | Molecular profi... | 18 Years - | Samsung Medical Center | |
| The Screening Protocol for The VIKTORY Trial | NCT02299648 | Stomach Neoplas... | Molecular profi... | 18 Years - | Samsung Medical Center | |
| Feasibility of a Molecular Characterisation Approach to Treatment | NCT02112357 | Advanced Gastro... | 18 Years - | Royal Marsden NHS Foundation Trust | ||
| A Combination of Acalabrutinib With R-CHOP for Patient Diffuse Large B-cell Lymphoma (DLBCL) | NCT03571308 | Non Hodgkin Lym... | R-CHOP + acalab... | 16 Years - | University Hospital Southampton NHS Foundation Trust | |
| Molecular Profiling of Advanced Biliary Tract Cancers | NCT04318834 | Biliary Tract C... | Tumour and germ... | 18 Years - | McGill University Health Centre/Research Institute of the McGill University Health Centre | |
| A MolEcularly Guided Anti-Cancer Drug Off-Label Trial | NCT04185831 | Solid Tumor | Atezolizumab Everolimus Cobimetinib | 18 Years - | Uppsala University Hospital | |
| US NAB With ROSE Versus US FNAB With no ROSE | NCT04618874 | Lung Cancer | Rapid on-site e... | 18 Years - | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | |
| Collection of Tissue Blocks or Slides From Patients With Cancer | NCT02810405 | Tumor Carcinogens Neoplasm, Benig... Benign Neoplasm... Cancer | 18 Years - | National Institutes of Health Clinical Center (CC) | ||
| Ontario-wide Cancer TArgeted Nucleic Acid Evaluation | NCT02906943 | Breast Cancer Lung Cancer Colorectal Canc... Melanoma Gynecological C... Genitourinary C... Pancreatobiliar... Gastrointestina... Head and Neck C... Rare Cancer Unknown Primary... | 18 Years - | University Health Network, Toronto | ||
| POA Retrospective Repository | NCT03326479 | Oncology Solid Tumor, Ad... | Caris Molecular... | 18 Years - | Caris Science, Inc. | |
| Multi-Omic Assessment of Squamous Cell Cancers Receiving Systemic Therapy | NCT03712566 | Cancer Esophagus Squam... Squamous Cell C... Anal Canal Squa... Metastatic Canc... | 18 Years - | University Health Network, Toronto | ||
| Pancreatic Cancer Adaptive Neoadjuvant Chemotherapy Trial | NCT03322995 | Pancreatic Canc... | First-line Chem... Second-line Che... Chemoradiation | 18 Years - | Medical College of Wisconsin | |
| Acalabrutinib in Combination With R-CHOP for Previously Untreated Diffuse Large B-cell Lymphoma (DLBCL) | NCT04546620 | Diffuse Large B... | R-CHOP R-CHOP + acalab... | 16 Years - | University Hospital Southampton NHS Foundation Trust | |
| Selection Pressure and Evolution Induced by Immune Checkpoint Inhibitors and Other Immunologic Therapies | NCT02724488 | Head and Neck C... Melanoma | 18 Years - | University Health Network, Toronto | ||
| A Randomised Evaluation of Molecular Guided Therapy for Diffuse Large B-cell Lymphoma With Bortezomib | NCT01324596 | Lymphoma, Large... | Intravenous Bortezomib | 18 Years - | University Hospital Southampton NHS Foundation Trust | |
| Molecular Characteristics of Gastroesophageal Adenocarcinoma (MOCHA): A Prospective Feasibility Study | NCT04219137 | Esophagogastric... | Molecular Profi... | 18 Years - | University Health Network, Toronto | |
| A Pilot Study Utilizing Proteomic and Genomic Profiling for Patients With Metastatic Breast Cancer | NCT01919749 | Metastatic Brea... | treated recomme... | 18 Years - | Translational Drug Development | |
| A Study of Drug Therapies for Salivary Gland Cancers Based on Testing of Genes | NCT02069730 | Salivary Gland ... Metastatic Advanced Recurrent | Selinexor EGFR or HER2 In... FGFR Inhibitor C-KIT Inhibitor Anti-androgen NOTCH Inhibitor MEK or PI3K Inh... | 18 Years - | University Health Network, Toronto | |
| New Prospective Expanded German Registry of Incidental Gallbladder Carcinoma (PERSUASION)- a Permanent Platform Including All Kind of Biliary Tract Cancers (BTC) | NCT04896931 | Biliary Tract C... Neoadjuvant, Ad... | 18 Years - | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest | ||
| Liquid Biopsy Evaluation and Repository Development at Princess Margaret | NCT03702309 | Cancer Breast Cancer Lung Cancer Colon Cancer Ovarian Cancer Melanoma Lymphoma Leukemia Mutation Lynch Syndrome Cowden Syndrome BRCA1 Mutation BRCA2 Mutation Uterine Cancer Myeloma Kidney Cancer Head and Neck C... Meningioma | 18 Years - | University Health Network, Toronto |
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