Spots Global Cancer Trial Database for Molecular Analysis of Retinoblastoma

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Trial Identification

Brief Title: Molecular Analysis of Retinoblastoma

Official Title: Molecular Analysis of Retinoblastoma

Study ID: NCT00718783

Conditions

Retinoblastoma

Interventions

Tissue samples taken from retinoblastoma

5 ml peripheral blood

Study Description

Brief Summary: Retinoblastoma is a childhood tumor of the retina that affects approximately 1 in 18,000 children. Retinoblastoma is more prevalent in Central America, where most patients present with advanced intraocular and extraocular disease. Therefore, we have formed collaboration with Central American investigators to provide us with frozen retinoblastoma tumors from patients undergoing routine enucleation. The objective of this protocol is to begin to identify the mutations and gene expression changes that occur in retinoblastoma cells following RB1 gene inactivation in order to more effectively target chemotherapy for treating bilateral retinoblastoma.

Detailed Description: This is a biology protocol with no treatment regimen associated. Following routine enucleation of the retinoblastoma affected eye, a portion of the tumor will be removed and flash frozen and sent to St. Jude for RNA and DNA analysis. Some tissue will undergo histopathological analysis and tissue microarrays will be isolated.