Spots Global Cancer Trial Database for A Study of Tocilizumab (RoActemra/Actemra) in Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Participants With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biologic DMARD Therapy or the First Anti-TNF Biologic Agent
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Trial Identification
Brief Title: A Study of Tocilizumab (RoActemra/Actemra) in Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Participants With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biologic DMARD Therapy or the First Anti-TNF Biologic Agent
Official Title: Open-Label, Phase IIIb Study to Evaluate the Efficacy and Safety of Subcutaneous (SC) Tocilizumab Monotherapy or Combination Therapy With Methotrexate (MTX) or Other Non-Biologic Disease Modifying Anti-Rheumatic Drugs (DMARDs) in Patients With Active Rheumatoid Arthritis (RA) Who Have an Inadequate Response to Current Non-Biologic DMARD Therapy or the First Anti-Tumour Necrosis Factor (Anti-TNF) Biologic Agent
Study ID: NCT02046603
Conditions
Study Description
Brief Summary: This open-label study will evaluate the efficacy and safety of tocilizumab as monotherapy or in combination with methotrexate or other non-biologic disease modifying anti-rheumatic drugs (DMARDs) in participants with active rheumatoid arthritis (RA) and an inadequate response to current non-biologic DMARD therapy or the first anti-tumour necrosis factor (anti-TNF) agent. Participants will receive tocilizumab 162 milligrams (mg) subcutaneously once a week for 52 weeks.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Aberdeen Royal Infirmary, Aberdeen, , United Kingdom
Christchurch Hospital; Rheumatology, Bournemouth, , United Kingdom
Royal Sussex County Hospital; Clinical Investigation Research Unit, Brighton, , United Kingdom
Queens Hospital, Burton on Trent, , United Kingdom
West Suffolk Hospital, Bury Saint Edmonds, , United Kingdom
Addenbrooke'S Hospital; Rheumatology Research Unit, Cambridge, , United Kingdom
Cannock Chase Hospital; Rheumatology, Cannock, , United Kingdom
University Hospital of Wales; Dept of Rhematology, Cardiff, , United Kingdom
Broomfield Hospital, Chelmsford, , United Kingdom
Countess of Chester Hospital; Dept of Rheumatology, Chester, , United Kingdom
Dewsbury & District Hospital; Dept of Rheumatology, Dewsbury, , United Kingdom
Russells Hall Hospital; Rheumatology Department, Dudley, , United Kingdom
Ninewells Hospital, Dundee, , United Kingdom
Eastbourne District General Hospital; Dept of Rheumatology, Eastbourne, , United Kingdom
Western General Hospital; Pharmacy Department, Edinburgh, , United Kingdom
Gartnavel General Hospital; Rheumatology, Glasgow, , United Kingdom
Diana Princess of Wales Hosp., Grimsby, , United Kingdom
Princess Alexandra Hospital, Harlow, , United Kingdom
Northwick Park Hospital, Harrow, , United Kingdom
Hemel Hempstead General Hospital; Rheumatology Dept, Hemel Hempstead, , United Kingdom
Hull Royal Infirmary; Rheumatology Department, Hull, , United Kingdom
Llandudno General Hospital, Llandudno, , United Kingdom
Whipps Cross Hospital; Rheumatology Dept, London, , United Kingdom
Royal Free Hospital; Department of Rheumatology, London, , United Kingdom
Maidstone Hospital; Dept of Rheumatology, Maidstone, , United Kingdom
Wythenshawe Hospital, Manchester, , United Kingdom
Freeman Hospital; Dept of Rheumatology, Newcastle Upon Tyne, , United Kingdom
North Tyneside General Hospital, North Shields, , United Kingdom
Norfolk & Norwich Hospital; Rheumatology, Norwich, , United Kingdom
Integrated Care Centre, Oldham, , United Kingdom
Solihull Hospital, Solihull, , United Kingdom
Haywood Hospital; Staffordshire Rheumatology Centre, Stoke-on-trent, , United Kingdom
Great Western Hospital; Dept of Rheumatology, Swindon, , United Kingdom
Torbay Hospital; Dept of Rhematology, Torquay, , United Kingdom
Royal Cornwall Hospital; Rhuematololgy Dept, Truro, , United Kingdom
Warrington Hospital, Warrington, , United Kingdom
Wrightington Hospital; Rheumatology, Wigan, , United Kingdom
Wishaw General Hospital, Wishaw, , United Kingdom
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
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