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Spots Global Cancer Trial Database for A Study to Assess a PI3Kδ Inhibitor (IOA-244) in Patients With Metastatic Cancers

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Trial Identification

Brief Title: A Study to Assess a PI3Kδ Inhibitor (IOA-244) in Patients With Metastatic Cancers

Official Title: First-in-Human Dose Study of IOA-244 Alone and in Combination With Pemetrexed/Cisplatin in Patients With Advanced or Metastatic Cancers

Study ID: NCT04328844

Study Description

Brief Summary: The objective of study IOA-244-101 is to determine whether IOA-244 is safe and tolerable in cancer patients (Part A). In addition, the study will assess whether IOA-244 can increase the anti-tumour immune response in patients both as monotherapy and in combination pemetrexed/cisplatin/avelumab (Part B Mesothelioma and NSCLC 1st line), in combination with avelumab (Part B Cutaneous Melanoma and NSCLC 2nd/3rd line) and ruxolitinib (Part B Primary Myelofibrosis)

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Humanitas Research Hospital, Rozzano, Milan, Italy

Medical Oncology and Immunotherapy Unit, University Hospital of Siena, Siena, , Italy

Beatson West of Scotland Cancer Centre, Glasgow, , United Kingdom

Contact Details

Name: Michael Lahn

Affiliation: iOnctura

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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