Spots Global Cancer Trial Database for uveal melanoma
Every month we try and update this database with for uveal melanoma cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.
The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
| Study title | NCT ID | Conditions | Interventions | Eligibility | Organization | Link |
|---|---|---|---|---|---|---|
| Vascular Response to Brachytherapy Using Functional OCT | NCT01955941 | Uveal Melanoma | 18 Years - | OHSU Knight Cancer Institute | ||
| TTT Versus TTT and Triamcinolone to Decrease Exudation in Choroidal Melanoma After Proton Beam Therapy | NCT02379000 | Exudative Retin... Uveal Melanoma | Triamcinolone A... Transpupillary ... | 18 Years - | Charite University, Berlin, Germany | |
| A Study to Assess a PI3Kδ Inhibitor (IOA-244) in Patients With Metastatic Cancers | NCT04328844 | Solid Tumor, Ad... Non-Hodgkin Lym... NSCLC Myelofibrosis Uveal Melanoma | IOA-244 Avelumab Inject... Pemetrexed Cisplatin Ruxolitinib | 18 Years - | iOnctura | |
| Endoresection of the Tumor Scar or Transpupillary Thermotherapy for the Treatment of Large Uveal Melanomas (Endoresection-Laser) | NCT02874040 | Uveal Melanoma Melanoma, Uveal | Endoresection Laser diode | 18 Years - | Institut Curie | |
| Study of PAC-1 and Entrectinib for Patients With Metastatic Uveal Melanoma | NCT04589832 | Uveal Melanoma | PAC-1 Entrectinib | 18 Years - | Hoosier Cancer Research Network | |
| Trial of Nivolumab in Combination With Ipilimumab in Subjects With Previously Untreated Metastatic Uveal Melanoma | NCT02626962 | Uveal Melanoma | ipilimumab Nivolumab | 18 Years - 99 Years | Grupo Español Multidisciplinar de Melanoma | |
| Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Ocular Melanoma | NCT01814046 | Metastatic Ocul... Metastatic Uvea... | Aldesleukin Cyclophosphamid... Fludarabine Young Tumor Inf... | 16 Years - 75 Years | National Institutes of Health Clinical Center (CC) | |
| Stereotactic Body Radiation Therapy and Aflibercept in Treating Patients With Uveal Melanoma | NCT03712904 | Uveal Melanoma | Stereotactic Bo... Ziv-Aflibercept | 18 Years - | Thomas Jefferson University | |
| Uveal Melanoma and Brachytheraphy: Long-term Outcomes. | NCT04577742 | 106 Ruthenium P... Uveal Melanoma | 106 Ruthenium p... | 40 Years - 80 Years | Federico II University | |
| Melanoma Vaccine With Peptides and Leuprolide | NCT00254397 | Melanoma | Leuprolide GP100: 209-217(... MAGE-3 Peptide | 18 Years - | M.D. Anderson Cancer Center | |
| Sitravatinib and Tislelizumab in Patients With Metastatic Uveal Melanoma With Liver Metastases. | NCT05542342 | Uveal Melanoma | Tislelizumab Sitravatinib Ma... | 18 Years - | Grupo Español Multidisciplinar de Melanoma | |
| Tebentafusp in HLA-A*0201 Positive Previously Untreated Metastatic Uveal Melanoma | NCT06070012 | Uveal Melanoma | Tebentafusp | 18 Years - | University of Pittsburgh | |
| Study of RP2 Monotherapy and RP2 in Combination With Nivolumab in Patients With Solid Tumors | NCT04336241 | Cancer | RP2 nivolumab | 18 Years - | Replimune Inc. | |
| A Phase Ib/II Study of AEB071 and MEK162 in Adult Patients With Metastatic Uveal Melanoma | NCT01801358 | Uveal Melanoma | AEB071 MEK162 | 18 Years - | Array BioPharma | |
| Intravitreal Ranibizumab for the Prevention of Radiation Maculopathy Following Plaque Radiotherapy | NCT00540930 | Uveal Melanoma Radiation Retin... Radiation Macul... | Ranibizumab | 18 Years - | Shields, Shields and Associates | |
| A Study of RO7293583 in Participants With Unresectable Metastatic Tyrosinase Related Protein 1 (TYRP1)-Positive Melanomas | NCT04551352 | Cutaneous Melan... Uveal Melanoma Mucosal Melanom... | RO7293583 Tocilizumab Obinutuzumab Adalimumab | 18 Years - | Hoffmann-La Roche | |
| A Study to Assess a PI3Kδ Inhibitor (IOA-244) in Patients With Metastatic Cancers | NCT04328844 | Solid Tumor, Ad... Non-Hodgkin Lym... NSCLC Myelofibrosis Uveal Melanoma | IOA-244 Avelumab Inject... Pemetrexed Cisplatin Ruxolitinib | 18 Years - | iOnctura | |
| Genasense, Carboplatin, Paclitaxel (GCP) Combination in Uveal Melanoma | NCT01200342 | Melanoma | Genasense Paclitaxel Carboplatin | 18 Years - | M.D. Anderson Cancer Center | |
| Early Integration of Supportive Care for Metastatic Uveal Melanoma Patients (EarlyTogether) | NCT04728113 | Uveal Melanoma | Supportive care... Oncological sta... | 18 Years - | Institut Curie | |
| Intrahepatic Delivery of SD-101 by Pressure-Enabled Regional Immuno-oncology (PERIO), With Checkpoint Blockade in Adults With Metastatic Uveal Melanoma | NCT04935229 | Metastatic Uvea... | SD-101 Nivolumab Ipilimumab Nivolumab and R... | 18 Years - | TriSalus Life Sciences, Inc. | |
| Morphological, Genetic and Tumour Microenvironment Characterisation in Uveal Melanoma | NCT05889481 | Uveal Melanoma | cytogenetic ana... Digital Patholo... | 18 Years - | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | |
| Dendritic Cells Plus Autologous Tumor RNA in Uveal Melanoma | NCT01983748 | Uveal Melanoma | Autologous Dend... | 18 Years - 75 Years | University Hospital Erlangen | |
| Isolated Hepatic Perfusion in Combination With Ipilimumab and Nivolumab in Patients With Uveal Melanoma Metastases | NCT04463368 | Uveal Melanoma Liver Metastase... | Isolated hepati... Ipilimumab Nivolumab | 18 Years - | Vastra Gotaland Region | |
| Study Evaluating Single and Repeated Intravitreal Doses of ICON-1 in Patients With Uveal Melanoma | NCT02771340 | Uveal Melanoma Choroid Neoplas... | ICON-1 | 18 Years - | Iconic Therapeutics, Inc. | |
| A Study of Sorafenib in Patients With Chemonaive Metastatic Uveal Melanoma | NCT01377025 | Uveal Melanoma | Placebo Sorafenib Sorafenib | 18 Years - | University Hospital, Essen | |
| Single Arm Trial of Tumor-Treating Fields in Combination With Nivolumab and Ipilimumab in Metastatic Uveal Melanoma | NCT05004025 | Uveal Melanoma | Novocure Optune Opdivo Yervoy | 18 Years - 100 Years | HonorHealth Research Institute | |
| Yttrium90, Ipilimumab, & Nivolumab for Uveal Melanoma With Liver Metastases | NCT02913417 | Uveal Melanoma Hepatic Metasta... | SIR-Spheres® Yt... ipilimumab nivolumab | 18 Years - | California Pacific Medical Center Research Institute | |
| Tilting of Radioactive Plaques After Initial Accurate Placement for Treatment of Uveal Melanoma | NCT00459849 | Uveal Melanoma | Intraoperative ... | 18 Years - | Barnes Retina Institute | |
| Influence of Oral Treatment With Citicoline for the Prevention of Radiation Optic Neuropathy in Patients Treated for Uveal Melanomas With Proton Beam Therapy | NCT01338389 | Uveal Melanoma | CITICOLINE PLACEBO | 18 Years - | Centre Hospitalier Universitaire de Nice | |
| Study of the Activity of PD-1 Inhibitors in Metastatic Uveal Melanoma | NCT03964298 | Uveal Melanoma | - | Institut Curie | ||
| Melanoma Inhibitory Activity (MIA): A Serological Marker for Metastatic Uveal Melanoma | NCT00406900 | Melanoma Radiotherapy Metastatic Dise... | Treatment of me... | - | Ludwig-Maximilians - University of Munich | |
| Gene Modified Immune Cells (IL13Ralpha2 CAR T Cells) After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors | NCT04119024 | Metastatic Mali... Metastatic Mela... Pathologic Stag... Pathologic Stag... Recurrent Malig... Refractory Mali... Uveal Melanoma Acral Melanoma Neuroendocrine ... Paraganglioma Pheochromocytom... Adrenocortical ... Pancreatic Neur... Thyroid Cancer Breast Cancer Lung Adenocarci... Head and Neck S... | Biopsy Biospecimen Col... Computed Tomogr... Cyclophosphamid... Fludarabine Pho... Fludeoxyglucose... IL13Ralpha2-spe... Magnetic Resona... Positron Emissi... | 18 Years - 70 Years | Jonsson Comprehensive Cancer Center | |
| Study in Subjects With Small Primary Choroidal Melanoma | NCT03052127 | Uveal Melanoma Ocular Melanoma Choroidal Melan... | Light-activated... Laser Activatio... | 18 Years - | Aura Biosciences | |
| Genasense, Carboplatin, Paclitaxel (GCP) Combination in Uveal Melanoma | NCT01200342 | Melanoma | Genasense Paclitaxel Carboplatin | 18 Years - | M.D. Anderson Cancer Center | |
| Safety and Efficacy of IMCgp100 Versus Investigator Choice in Advanced Uveal Melanoma | NCT03070392 | Uveal Melanoma | IMCgp100 Dacarbazine Ipilimumab Pembrolizumab | 18 Years - 99 Years | Immunocore Ltd | |
| Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Ocular Melanoma | NCT01814046 | Metastatic Ocul... Metastatic Uvea... | Aldesleukin Cyclophosphamid... Fludarabine Young Tumor Inf... | 16 Years - 75 Years | National Institutes of Health Clinical Center (CC) | |
| Longitudinal Follow-Up of Patients Treated With Hypofractionated Stereotactic Photon Radiotherapy Due to Uveal Melanoma | NCT06280040 | Uveal Melanoma | Clinical examin... | 18 Years - | Medical University of Vienna | |
| Efficacy Study of Pembrolizumab With Entinostat to Treat Metastatic Melanoma of the Eye | NCT02697630 | Metastatic Uvea... | Pembrolizumab Entinostat | 18 Years - | Vastra Gotaland Region | |
| Sitravatinib and Tislelizumab in Patients With Metastatic Uveal Melanoma With Liver Metastases. | NCT05542342 | Uveal Melanoma | Tislelizumab Sitravatinib Ma... | 18 Years - | Grupo Español Multidisciplinar de Melanoma | |
| Safety & Activity of Controllable PRAME-TCR Therapy in Previously Treated AML/MDS or Metastatic Uveal Melanoma | NCT02743611 | Acute Myeloid L... Myelodysplastic... Uveal Melanoma | BPX-701 Rimiducid | 18 Years - | Bellicum Pharmaceuticals | |
| Melphalan Chemoreduction for Ocular Melanoma | NCT05893654 | Uveal Melanoma | Melphalan Injec... Plaque brachyth... | 18 Years - | Hospital das Clínicas de Ribeirão Preto | |
| Assessing the Clinical Effectiveness of Serum Biomarkers in the Diagnosis of Metastatic Uveal Melanoma | NCT01438658 | Uveal Melanoma | - | Hadassah Medical Organization | ||
| A Study of Sorafenib in Patients With Chemonaive Metastatic Uveal Melanoma | NCT01377025 | Uveal Melanoma | Placebo Sorafenib Sorafenib | 18 Years - | University Hospital, Essen | |
| Psychoeducation for Uveal Melanoma | NCT06075589 | Uveal Melanoma | Education for I... Best Practice | 18 Years - | Jonsson Comprehensive Cancer Center | |
| Tilting of Radioactive Plaques After Initial Accurate Placement for Treatment of Uveal Melanoma | NCT00459849 | Uveal Melanoma | Intraoperative ... | 18 Years - | Barnes Retina Institute | |
| Transarterial Radioembolisation in Comparison to Transarterial Chemoembolisation in Uveal Melanoma Liver Metastasis | NCT02936388 | Uveal Melanoma | SIRT DSM-TACE | 18 Years - 99 Years | Charite University, Berlin, Germany | |
| The Role of Genetic Mutations and of Circulating mRNAs in Uveal Melanoma | NCT05179174 | Uveal Melanoma | blood sample ex... | 18 Years - | University of Catania | |
| Early Integration of Supportive Care for Metastatic Uveal Melanoma Patients (EarlyTogether) | NCT04728113 | Uveal Melanoma | Supportive care... Oncological sta... | 18 Years - | Institut Curie | |
| A Phase 1/2 Study of [225Ac]-FPI-1434 Injection | NCT03746431 | Advanced Solid ... Endometrial Can... Cervical Cancer Ovarian Cancer Breast Cancer Triple Negative... HER2-negative B... Head and Neck S... Adrenocortical ... Uveal Melanoma | [111In]-FPI-154... [225Ac]-FPI-143... FPI-1175 Infusi... [225Ac]-FPI-143... | 18 Years - | Fusion Pharmaceuticals Inc. | |
| Olaparib in Combination With Pembrolizumab for Advanced Uveal Melanoma | NCT05524935 | Uveal Melanoma Ocular Melanoma | Pembrolizumab Olaparib | 18 Years - | H. Lee Moffitt Cancer Center and Research Institute | |
| Endoresection of the Tumor Scar or Transpupillary Thermotherapy for the Treatment of Large Uveal Melanomas (Endoresection-Laser) | NCT02874040 | Uveal Melanoma Melanoma, Uveal | Endoresection Laser diode | 18 Years - | Institut Curie | |
| Hypofractionated Stereotactic Linear Accelerator Radiotherapy of Uveal Melanoma | NCT00872391 | Uveal Melanoma | Hypofractionate... | 18 Years - | Medical University of Vienna | |
| Evaluation Interest of the Circulating Tumor DNA Dosage in Patient With Hepatic Metastatic Uveal Melanoma Candidate to Complete Resection (ct DNA R0) | NCT02849145 | Uveal Melanoma | Blood sampling | 18 Years - | Institut Curie | |
| Dexamethasone Intravitreal Implant for Treatment of Macular Edema After Plaque Radiotherapy of Uveal Melanoma | NCT01471054 | Macular Edema Cystoid Macular... Uveal Melanoma Radiation Macul... Radiation Retin... | Ozurdex Bevacizumab | 18 Years - | Wills Eye | |
| Locoregional Administration of TIL and Lymphodepletion in Patients With Melanoma and Liver Metastases | NCT05903937 | Uveal Melanoma Metastatic Cuta... | Autologous Tumo... Melphalan Interleukin-2 | 18 Years - | Vastra Gotaland Region | |
| Isolated Hepatic Perfusion in Combination With Ipilimumab and Nivolumab in Patients With Uveal Melanoma Metastases | NCT04463368 | Uveal Melanoma Liver Metastase... | Isolated hepati... Ipilimumab Nivolumab | 18 Years - | Vastra Gotaland Region | |
| Phase 2 Trial to Evaluate Belzupacap Sarotalocan (AU-011) Via Suprachoroidal Administration in Subjects With Primary Indeterminate Lesions and Small Choroidal Melanoma | NCT04417530 | Uveal Melanoma Ocular Melanoma Choroidal Melan... | AU-011 Suprachoroidal ... PDT Laser | 18 Years - | Aura Biosciences | |
| Vorinostat in Patients With Class 2 High Risk Uveal Melanoma | NCT03022565 | Uveal Melanoma | Vorinostat | 18 Years - | University of Miami | |
| Dexamethasone Implant for Retinal Detachment in Uveal Melanoma | NCT04082962 | Exudative Retin... | Dexamethasone i... | 18 Years - | Massachusetts Eye and Ear Infirmary | |
| Treatment With Intravitreal Avastin for Large Uveal Melanomas | NCT00596362 | Uveal Melanoma | AVASTIN | 18 Years - | Memorial Sloan Kettering Cancer Center | |
| (Neo)Adjuvant IDE196 (Darovasertib) in Patients With Localized Ocular Melanoma | NCT05907954 | Uveal Melanoma | Darovasertib | 18 Years - | IDEAYA Biosciences | |
| Combined PET/CT Imaging for the Early Detection of Ocular Melanoma Metastasis Compared to CT Scanning Alone | NCT00351728 | Ocular Melanoma Choroidal Melan... Uveal Melanoma | 18 Years - | Jonsson Comprehensive Cancer Center | ||
| IMCgp100-401 Rollover Study | NCT02889861 | Malignant Melan... | IMCgp100 | 18 Years - | Immunocore Ltd | |
| Study of Immunotherapy Plus ADI-PEG 20 for the Treatment of Advanced Uveal Melanoma | NCT03922880 | Uveal Melanoma | ADI PEG20 Nivolumab Ipilimumab | 18 Years - | Memorial Sloan Kettering Cancer Center | |
| Safety and Efficacy of IMCgp100 Versus Investigator Choice in Advanced Uveal Melanoma | NCT03070392 | Uveal Melanoma | IMCgp100 Dacarbazine Ipilimumab Pembrolizumab | 18 Years - 99 Years | Immunocore Ltd | |
| Retrospective Register for Uveal Melanoma | NCT05733728 | Uveal Melanoma | any therapy sui... | 18 Years - 99 Years | Medical University of Vienna | |
| Adjuvant Tebentafusp in High Risk Ocular Melanoma | NCT06246149 | Uveal Melanoma | Tebentafusp | 18 Years - | European Organisation for Research and Treatment of Cancer - EORTC | |
| Olaparib in Unresectable/Metastatic Melanoma With BRCA1/2 | NCT05482074 | Recurrent Metas... Cutaneous Melan... Mucosal Melanom... Uveal Melanoma | Olaparib | 18 Years - | Dana-Farber Cancer Institute | |
| A Trial of Niraparib in BAP1 and Other DNA Damage Response (DDR) Deficient Neoplasms (UF-STO-ETI-001) | NCT03207347 | Mesothelioma Uveal Melanoma Renal Cell Carc... Cholangiocarcin... | Niraparib | 18 Years - 80 Years | University of Florida | |
| Prospective Registration Of Patient Data and Quality of Life in Eye Melanoma Patients | NCT05377957 | Uveal Melanoma | Quality of life... Discrete choice... Shared decision... Impact of side-... | 18 Years - | Leiden University Medical Center | |
| Study Evaluating Single and Repeated Intravitreal Doses of ICON-1 in Patients With Uveal Melanoma | NCT02771340 | Uveal Melanoma Choroid Neoplas... | ICON-1 | 18 Years - | Iconic Therapeutics, Inc. | |
| Study in Subjects With Small Primary Choroidal Melanoma | NCT03052127 | Uveal Melanoma Ocular Melanoma Choroidal Melan... | Light-activated... Laser Activatio... | 18 Years - | Aura Biosciences | |
| Endoresection of the Tumor Scar or Transpupillary Thermotherapy for the Treatment of Large Uveal Melanomas (Endoresection-Laser) | NCT02874040 | Uveal Melanoma Melanoma, Uveal | Endoresection Laser diode | 18 Years - | Institut Curie | |
| Optical Coherence Tomography of Retinal Abnormalities Associated With Choroidal Nevus, Choroidal Melanoma and Choroidal Melanoma Treated With Iodine-125 Brachytherapy | NCT00346372 | Ocular Melanoma | 18 Years - | Jonsson Comprehensive Cancer Center | ||
| (Neo)Adjuvant IDE196 (Darovasertib) in Patients With Localized Ocular Melanoma | NCT05907954 | Uveal Melanoma | Darovasertib | 18 Years - | IDEAYA Biosciences | |
| 5 Year Registry Study to Track Clinical Application of DecisionDx-UM Assay Results and Associated Patient Outcomes | NCT02376920 | Uveal Melanoma | 16 Years - | Castle Biosciences Incorporated | ||
| Treatment With Intravitreal Avastin for Large Uveal Melanomas | NCT00596362 | Uveal Melanoma | AVASTIN | 18 Years - | Memorial Sloan Kettering Cancer Center | |
| Stereotactic Body Radiation Therapy and Aflibercept in Treating Patients With Uveal Melanoma | NCT03712904 | Uveal Melanoma | Stereotactic Bo... Ziv-Aflibercept | 18 Years - | Thomas Jefferson University | |
| Cytogenetic Study of Ocular Melanoma | NCT00344799 | Choroidal Melan... | 18 Years - | Jonsson Comprehensive Cancer Center | ||
| Isolated Hepatic Perfusion in Combination With Ipilimumab and Nivolumab in Patients With Uveal Melanoma Metastases | NCT04463368 | Uveal Melanoma Liver Metastase... | Isolated hepati... Ipilimumab Nivolumab | 18 Years - | Vastra Gotaland Region |
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