Spots Global Cancer Trial Database for First-in-Human Study of EOS100850 in Patients With Cancer
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Trial Identification
Brief Title: First-in-Human Study of EOS100850 in Patients With Cancer
Official Title: Phase I/Ib First-in-Human Study of EOS100850 as a Single Agent and in Combination With Pembrolizumab and/or Chemotherapy in Participants With Advanced Cancers
Study ID: NCT03873883
Conditions
Study Description
Brief Summary: Multicenter, open-label, dose-escalation Phase I/Ib clinical study to evaluate the safety and tolerability, the MTD/RP2D, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of EOS100850 as a Single Agent and in Combination with Pembrolizumab and/or Chemotherapy in Participants with Advanced Cancers.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Karmanos Cancer Institute, Michigan Center, Michigan, United States
John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey, United States
University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States
Hospital GZA Sint-Augustinus, Wilrijk, Antwerp, Belgium
Institut Jules Bordet, Brussels, , Belgium
UCL Saint-Luc, Brussels, , Belgium
UZ Ghent, Ghent, , Belgium
Centre de Lutte Contre le Cancer (CLCC) - Universite de Lyon - Centre Leon-Berard, Lyon, , France
Centre Hospitalier Universitaire de Poitiers - Hopital la Miletrie- Pôle Régional de Cancérologie, Poitiers, , France
Centre de Lutte Contre le Cancer - Institut de Cancerologie de l'Ouest - Rene Gauducheau, Saint-Herblain, , France
Gustave Roussy, Villejuif, , France
Yonsei University Severance Hospital, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
St Mary's Hospital, The Catholic University of Korea, Seoul, , Korea, Republic of
Hospital del Mar, Barcelona, , Spain
START Madrid-HM CIOCC Hospital Universitario HM Sanchinarro, Madrid, , Spain
Universidad de Navarra - Clinica Universitaria de Navarra, Pamplona, , Spain
Onkologikoa, San Sebastián, , Spain
The Royal Marsden NHS Foundation Trust - Royal Marsden Hospital, Sutton, , United Kingdom
Contact Details
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