Spots Global Cancer Trial Database for Identification of the Pathogenetic Mechanisms Underlying Squamous Cell Carcinomas

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Trial Identification

Brief Title: Identification of the Pathogenetic Mechanisms Underlying Squamous Cell Carcinomas

Official Title: Identification of the Pathogenetic Mechanisms Underlying Squamous Cell Carcinomas of the Anogenital Tract and of the Head-neck Region for the Development of Shared Therapeutic Strategies

Study ID: NCT06236464

Conditions

Squamous Cell Carcinoma of the Head and Neck

Squamous Cell Carcinoma of the Anus

Interventions

Multiparameter analysis of each sample

Study Description

Brief Summary: This is a multicentric, retrospective, and prospective biomarker study.

Detailed Description: This is a multicentric, retrospective, and prospective biomarker study, involving a total of 170 patients with SCC (Squamous Cell Carcinoma) of the mucosa of the anogenital tract and head-neck region, recruited from INT-NA (n=50), UPO (n=40), AOUP (n=40), and ITB (n=40). Specifically, retrospective and prospective samples will be collected and analyzed for the study of molecular and viral biomarkers. Simultaneously, fibroblastic tumor-associated cells (CAFs) will be isolated from prospective samples. Through co-cultivation with immortalized cell lines derived from anogenital and head-neck SCCs, these CAFs will enable the production of 3D organoids for use in experiments assessing the response to telomerase and deacetylase SIRT1 inhibitors, both in vitro and in preclinical models.