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Spots Global Cancer Trial Database for Docetaxel and Irinotecan in Gastric Cancer

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Trial Identification

Brief Title: Docetaxel and Irinotecan in Gastric Cancer

Official Title: Docetaxel and Irinotecan Combination as a Second Line Treatment of Metastatic Gastric Cancer; a Phase II Study

Study ID: NCT04770623

Interventions

Docetaxel
Irinotecan

Study Description

Brief Summary: To assess the role of docetaxel and irinotecan combination in second line gastric cancer. The primary end point is response rate. Secondary end points are toxicity, PFS and OS.

Detailed Description: Gastric cancer is a major killer in oncology. The expected overall survival of metastatic patients is less than 2 years. Moreover, most of the patients develop cachexia and worsening of performance over time. As a result, many patients are not fit for second line treatment when eligible. There is currently no approved consensus for third line treatment regimen and in most of the patients it is usually best supportive care. Irinotecan and docetaxel were tested as single agents or in combination with other drugs (e.g. FOLFIRI) in second line setting. However, the combination of these two drugs together was not tested before. Both agents are active in second line setting which is considered the last chance of the patient in view of lack of evidence in third line setting.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Menoufia University, Faculty of medicine, Shibīn Al Kawm, Menoufia, Egypt

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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