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Brief Title: Research on Precise Immune Prevention and Treatment of Glioma Based on Multi-omics Sequencing Data
Official Title: Research on Precise Immune Prevention and Treatment of Glioma Based on Multi-omics Sequencing Data
Study ID: NCT04792437
Brief Summary: This project intends to use multiple types of biological samples from glioma patients and mouse intracranial tumor models as research objects, and comprehensively apply a series of omics sequencing technologies and molecular biology technologies to jointly define the following research objectives :
Detailed Description: 1. Through high-throughput sequencing technologies such as, genome sequencing, transcriptome sequencing and single-cell sequencing, Proteomics,Metabonomics and Metagenomics, the similarities and differences of the glioma immune microenvironment within and between individuals were revealed from the multi-dimensional and big data level, and the immune molecular typing of glioma was established. 2. Establish and verify that the neoantigen polypeptides predicted by AI algorithm after analyzing multi-omics data (genome, transcriptome, etc.) have good killing effect on individual tumor cells. 3. To establish an intelligent evaluation model of glioma immunotyping by integrating imaging, pathology, high-throughput sequencing data and other omics information, and to provide a visual tool for monitoring changes in the intratumoral microenvironment of glioma patients, with the expectation of helping timely intervention of immunotherapy in patients with recurrence.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Huashan hospital, Fudan University, Shanghai, , China