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Spots Global Cancer Trial Database for CT-based Radiomics of ALN pCR (ypN0) in Breast Cancer Undergoing NAC

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Trial Identification

Brief Title: CT-based Radiomics of ALN pCR (ypN0) in Breast Cancer Undergoing NAC

Official Title: Computed Tomography-based Radiomics of Axillary Lymph Node Pathological Complete Remission (ypN0) in Breast Cancer Undergoing Neoadjuvant Chemotherapy

Study ID: NCT04457700

Interventions

Study Description

Brief Summary: This is a prospective, single-center, non-randomized, non-controlled observational study.

Detailed Description: Almost 55-62% of patients with triple-negative or human epidermal growth factor receptor 2 (HER2) positive, node-positive breast cancer achieve an axillary pathologic complete remission (pCR) after neoadjuvant chemotherapy (NAC). To avoid surgery post-NAC, it is paramount to accurately identify patients who achieve pCR in axillary lymph node (ALN). We found that patients with normal-appearing lymph nodes on computed tomography (CT) based radiomics of the axilla after chemotherapy had a lower risk of developing residual nodal disease. However, the features of CT-based radiomics for pCR ALN following NAC has not been established yet. This study aimed to assess the performance of CT-based radiomics in evaluating the response and predicting pCR of metastatic lymph nodes after NAC in breast cancer patients.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

Peking University Cancer Hospital, Beijing, Beijing, China

Contact Details

Name: Lize Wang, MD

Affiliation: Breast center at Peking University Cancer Hospital

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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