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Brief Title: CT-based Radiomics of ALN pCR (ypN0) in Breast Cancer Undergoing NAC
Official Title: Computed Tomography-based Radiomics of Axillary Lymph Node Pathological Complete Remission (ypN0) in Breast Cancer Undergoing Neoadjuvant Chemotherapy
Study ID: NCT04457700
Brief Summary: This is a prospective, single-center, non-randomized, non-controlled observational study.
Detailed Description: Almost 55-62% of patients with triple-negative or human epidermal growth factor receptor 2 (HER2) positive, node-positive breast cancer achieve an axillary pathologic complete remission (pCR) after neoadjuvant chemotherapy (NAC). To avoid surgery post-NAC, it is paramount to accurately identify patients who achieve pCR in axillary lymph node (ALN). We found that patients with normal-appearing lymph nodes on computed tomography (CT) based radiomics of the axilla after chemotherapy had a lower risk of developing residual nodal disease. However, the features of CT-based radiomics for pCR ALN following NAC has not been established yet. This study aimed to assess the performance of CT-based radiomics in evaluating the response and predicting pCR of metastatic lymph nodes after NAC in breast cancer patients.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Peking University Cancer Hospital, Beijing, Beijing, China
Name: Lize Wang, MD
Affiliation: Breast center at Peking University Cancer Hospital
Role: PRINCIPAL_INVESTIGATOR