Spots Global Cancer Trial Database for A Study of Adavosertib as Treatment for Uterine Serous Carcinoma
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Trial Identification
Brief Title: A Study of Adavosertib as Treatment for Uterine Serous Carcinoma
Official Title: A Phase 2b, Open-label, Single-arm, Multi-centre Study Assessing the Efficacy and Safety of Adavosertib as Treatment for Recurrent or Persistent Uterine Serous Carcinoma
Study ID: NCT04590248
Conditions
Interventions
Study Description
Brief Summary: This Phase 2b study aims to evaluate the efficacy and safety of adavosertib, an inhibitor of the tyrosine kinase WEE1, in subjects with recurrent or persistent uterine serous carcinoma (USC) who have previously received at least 1 prior platinum-based chemotherapy regimen for the management of USC.
Detailed Description: This Phase 2b, open-label, single-arm, multi-center study will assess the efficacy and safety of adavosertib in eligible subjects with histologically confirmed recurrent or persistent USC, evidence of measurable disease as per Response Evaluation Criteria in Solid Tumors.(RECIST) v1.1, and who have received at least 1 prior platinum-based chemotherapy regimen for the management of USC. Subjects with carcinosarcomas are not eligible.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
Research Site, Burbank, California, United States
Research Site, Duarte, California, United States
Research Site, La Jolla, California, United States
Research Site, West Hollywood, California, United States
Research Site, Aurora, Colorado, United States
Research Site, Iowa City, Iowa, United States
Research Site, Covington, Louisiana, United States
Research Site, Boston, Massachusetts, United States
Research Site, Rochester, Minnesota, United States
Research Site, New Brunswick, New Jersey, United States
Research Site, Bronx, New York, United States
Research Site, New York, New York, United States
Research Site, Spokane, Washington, United States
Research Site, Vancouver, Washington, United States
Research Site, Toronto, , Canada
Research Site, Dijon cedex, , France
Research Site, Marseille, , France
Research Site, Nice, , France
Research Site, Pierre Benite, , France
Research Site, Saint Herblain, , France
Research Site, Milan, , Italy
Research Site, Napoli, , Italy
Research Site, Roma, , Italy
Research Site, A Coruña, , Spain
Research Site, Barcelona, , Spain
Research Site, Barcelona, , Spain
Research Site, Pozuelo de Alarcón, , Spain
Contact Details
Name: Joyce Liu, MD, MPH
Affiliation: Dana-Farber Cancer Institute
Role: PRINCIPAL_INVESTIGATOR
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