Neoplasms

Digestive System Diseases

All Conditions

Rectal Neoplasms

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Intestinal Diseases

Rectal Diseases

Antineoplastic Agents

All Drugs and Chemicals

Micronutrients

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Capecitabine

Bevacizumab

Irinotecan

Leucovorin

Fluorouracil

Levoleucovorin

Oxaliplatin

Antineoplastic Agents, Immunological

Angiogenesis Inhibitors

Growth Inhibitors

Folinic Acid

INDUCTION TREATMENT WITH FOLFOXIRI PLUS BEVACIZUMAB FOLLOWED BY PREOPERATIVE CHEMORADIOTHERAPY PLUS BEVACIZUMAB

* BEVACIZUMAB 5 mg/kg over 30 minutes, day 1
* IRINOTECAN 165 mg/sqm IV over 1-h, day 1
* OXALIPLATIN 85 mg/sqm IV over 2-h, day 1
* L-LEUCOVORIN 200 mg/sqm IV over 2-h, day 1
* 5-FLUOROURACIL 3200 mg/sqm IV 48-h continuous infusion, starting on day 1 administered every two weeks for 6 cycles (3 months).

FOLFOXIRI plus Bevacizumab

* FLUOROURACIL 225 mg/sqm/day by protracted IV continuous infusion or -CAPECITABINE 825 mg/sqm/bid p.o. continuously without interruption for all the duration of radiation treatment;
* EXTERNAL-BEAM IRRADIATION 50.4 GY in 28 daily fractions over 5.5 weeks;
* BEVACIZUMAB 5 mg/kg over 30 minutes, starting on day 1 of radiation treatment day 1 and then every two weeks (for 3 cycles).

Chemoradiotherapy plus Bevacizumab

Alfredo Falcone, MD

This study includes patients affected by advanced and resectable rectal adenocarcinoma. It provides an induction chemotherapy with FOLFOXIRI regimen plus Bevacizumab followed by Chemoradiotherapy plus Bevacizumab. Surgery with total mesorectal incision must be performed within 7-9 weeks after this last treatment. The protocol will be evaluate the disease free survival at two years. Translational analyses will be performed to show the presence of VEGF polymorphism, CD133 surface markers on colorectal CSCs.

Folfoxiri Plus Bevacizumab Followed by Chemoradiotherapy Plus Bevacizumab in Patients With Resectable Rectal Cancer

Open-label Phase II Study of Induction Treatment With Folfoxiri Plus Bevacizumab Followed by Preoperative Chemoradiotherapy Plus Bevacizumab in Patients With Locally Advanced, Resectable Rectal Cancer.

Disease-free survival is defined as time from study entry until progression of disease (according to RECIST 1.1) or death from any cause. Patients who are alive without having progressed at the end of the study will be censored at their last radiological assessment.

Response rate is defined as the fraction of treated patients who achieve a response as defined according to Response Evaluation Criteria in Solid Tumors (RECIST) criteria vers. 1.1.

Toxicity Rate is defined as the percentage of patients, relative to the total of enrolled subjects, experiencing treatment-related adverse events as assessed by National Cancer Institute Common Toxicity Criteria (version 3.0), during induction and concomitant chemoradiotherapy

Overall survival is defined as the time from study entry until death from any cause. Patients who are alive at the end of the study will be censored at that point.

Pathological complete response rate is defined as the fraction of treated patients who achieve pathological response after treatment

Azienda Ospedaliero, Universitaria Pisana

Prof.

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Prostatic Neoplasms

Genital Neoplasms, Male

Urogenital Neoplasms

Genital Diseases

Genital Diseases, Male

Urogenital Diseases

Prostatic Diseases

Male Urogenital Diseases

Participants will view an online video with a Black doctor speaking about prostate cancer screening.

Black Doctor Screening Video

Participants will view an online video with a White doctor speaking about prostate cancer screening.

White Doctor Screening Video

Participants will view an online video with a Black patient speaking about prostate cancer screening.

Black Patient Screening Video

Participants will view an online video with a White patient speaking about prostate cancer screening.

White Patient Screening Video

Participants will view an online video with a Black doctor speaking about prostate cancer clinical trials.

Black Doctor Clinical Trials Video

Participants will view an online video with a White doctor speaking about prostate cancer clinical trials.

White Doctor Clinical Trials Video

Participants will view an online video with a Black patient speaking about prostate cancer clinical trials.

Black Patient Clinical Trials Video

Participants will view an online video with a White patient speaking about prostate cancer clinical trials.

White Patient Clinical Trials Video

Stacy Loeb, MD, MSc, PhD(hc)

The study team will evaluate the impact of video characteristics on health consumers' trust in online videos. Participants will be randomized to watch a video by one of four speakers about prostate cancer screening or clinical trials and complete a questionnaire (approximately 15 minutes total).

Randomized Trial of Trust in Online Videos About Prostate Cancer

Individual participant data needed for the proposed biomedical research use according to data use agreement from both parties will be shared.

Trust will be reported as a score on a Likert scale and asked as the following question: How much do you trust the information in the video? The total range of score is 1-4, where (1) trust the information completely, (2) trust most of the information, (3) trust some of the information, (4) do not trust the information

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Folfoxiri Plus Bevacizumab Followed by Chemoradiotherapy Plus Bevacizumab in Patients With Resectable Rectal Cancer	NCT03085992	Rectal Cancer	FOLFOXIRI plus ... Chemoradiothera...	18 Years - 75 Years	Azienda Ospedaliero, Universitaria Pisana
Folfoxiri Plus Bevacizumab Followed by Chemoradiotherapy Plus Bevacizumab in Patients With Resectable Rectal Cancer	NCT03085992	Rectal Cancer	FOLFOXIRI plus ... Chemoradiothera...	18 Years - 75 Years	Azienda Ospedaliero, Universitaria Pisana
Randomized Trial of Trust in Online Videos About Prostate Cancer	NCT05886751	Prostate Cancer	Black Doctor Sc... White Doctor Sc... Black Patient S... White Patient S... Black Doctor Cl... White Doctor Cl... Black Patient C... White Patient C...	40 Years -	NYU Langone Health

Spots Global Cancer Trial Database for trust

Every month we try and update this database with for trust cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for trust

Every month we try and update this database with for trust cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for trust cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.