Neoplasms

Immune System Diseases

All Conditions

Skin and Connective Tissue Diseases

Rare Diseases

Mastocytosis

Neoplasms, Connective Tissue

Neoplasms, Connective and Soft Tissue

Neoplasms by Histologic Type

Mast Cell Activation Disorders

Pediatric patients with documented mastocytosis

Pediatric relatives of patients with mastocytosis

Hye Jeong C Bolan, R.N.

Hirsh D Komarow, M.D.

For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

This study will examine growth factors that promote and inhibit mast cell proliferation resulting in mastocytosis, a disease of excessive mast cells in the body. These cells can release chemicals that cause itching, blisters, flushing, bone pain and abdominal pain.

Patients up to 80 years of age with mastocytosis may be eligible for this 1-day study. Participants will have one visit at NIH lasting up to 8 hours, during which they will undergo the following tests and procedures:

* Medical history and physical examination.
* Laboratory studies, if medically indicated.
* Blood tests to identify genetic changes important in the growth, development, and functioning of mast cells.
* Bone marrow aspiration and biopsy.

For the bone marrow procedure, the skin over the hipbone and the outer surface of the bone itself are numbed with local anesthesia. Then, a special needle is inserted into the hipbone and about 1 tablespoon of bone marrow is drawn into a syringe. Another needle is inserted into the same area to collect a small piece of the bone marrow. Additional procedures may include allergen testing, urinalysis, and 24-hour urine collection.

Participants will receive an evaluation of their mastocytosis.

...

This protocol is designed to examine those growth potentiating and inhibiting factors which regulate mast cell number and survival in patients with mastocytosis, and to explore the molecular basis of the disease process in hopes of improving therapy. Patients will carry the diagnosis of mastocytosis based on abnormal bone marrow biopsy and aspirate, abnormal skin biopsy, presence of urticaria pigmentosa, and if available, elevated serum tryptase level \> 20 ng/ml and the presence of aberrant mast cell morphology and surface markers of CD2 and CD25. Mastocytosis patients will include children and adults from zero years to 80 years of age. Unaffected relatives (age 2 to 80 years) may also be enrolled. The protocol is designated for up to a 1-year enrollment period; with only a small number of enrolled patients that will stay on study for more than one visit, based on investigator assessment of contribution to study objectives. Participants will undergo standard physical exam, medical history review, and blood collection for clinical and research laboratory evaluations. We will collect clinical data and biological specimens for research evaluation from individuals undergoing clinically indicated diagnostic procedures. Some patients may participate in research evaluations including buccal swab collection, dietary intake assessment, stool collection, exercise challenge, microbiome studies, and activity tracking. These studies are optional. Patients may be asked to re-enter this protocol at a later time for further follow-up.

Study of Factors Regulating Mast Cell Proliferation

Regulation of the Proliferation and Survival of Normal and Neoplastic Human Mast Cells

continuing collection of cells from subjects with mastocytosis for ongoing experimentation in laboratory

National Institute of Allergy and Infectious Diseases (NIAID)

This study will examine growth factors that promote and inhibit mast cell proliferation resulting in mastocytosis, a disease of excessive mast cells in the body. These cells can release chemicals that cause itching, blisters, flushing, bone pain and abdominal pain.

Patients up to 80 years of age with mastocytosis may be eligible for this 1-day study. Participants will have one visit at NIH lasting up to 8 hours, during which they will undergo the following tests and procedures:

* Medical history and physical examination.
* Laboratory studies, if medically indicated.
* Blood tests to identify genetic changes important in the growth, development, and functioning of mast cells.
* Bone marrow aspiration and biopsy.

For the bone marrow procedure, the skin over the hipbone and the outer surface of the bone itself are numbed with local anesthesia. Then, a special needle is inserted into the hipbone and about 1 tablespoon of bone marrow is drawn into a syringe. Another needle is inserted into the same area to collect a small piece of the bone marrow. Additional procedures may include allergen testing, urinalysis, and 24-hour urine collection.

Participants will receive an evaluation of their mastocytosis.

Study title	NCT ID	Conditions	Eligibility	Organization
Study of Factors Regulating Mast Cell Proliferation	NCT00044122	Mastocytosis Monoclonal Bone Marrow Tryptase	1 Day - 80 Years	National Institutes of Health Clinical Center (CC)
Study of Factors Regulating Mast Cell Proliferation	NCT00044122	Mastocytosis Monoclonal Bone Marrow Tryptase	1 Day - 80 Years	National Institutes of Health Clinical Center (CC)
Study of Factors Regulating Mast Cell Proliferation	NCT00044122	Mastocytosis Monoclonal Bone Marrow Tryptase	1 Day - 80 Years	National Institutes of Health Clinical Center (CC)

Spots Global Cancer Trial Database for tryptase

Every month we try and update this database with for tryptase cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for tryptase

Every month we try and update this database with for tryptase cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for tryptase cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.