Symptoms and General Pathology

All Conditions

Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

Recurrence

Carcinoma, Non-Small-Cell Lung

Lung Neoplasms

Carcinoma

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Carcinoma, Bronchogenic

Bronchial Neoplasms

High-risk margins were defined as R1 or R2 surgical margins or local recurrence during follow-up.

Low-risk margins were defined as R0 surgical margin meanwhile arising distant metastasis during follow-up.

extracted the tumor and peritumor radiomic feature from the preoperative enhanced chest CT

tumor and peritumor radiomic feature

Guangming Lu

The investigators retrospectively collected the participants with T3 and T4, N0-2, M0 NSCLC patients resected between January 2013 to December 2021 for training and internal validation. The Clinical data, preoperative laboratory results and images were collected. High-risk margins were defined as R1 or R2 surgical margins or local recurrence during follow-up, and the investigators also collected the disease-free survival time. On the Deepwise multi-modal research platform, the images were semi-automatically segmented and expanded outward by 3mm to obtain the peritumor tissue. PyRadiomics was used to extract the radiomic features. LASSO was used to select the features and tumor radiomics model, peritumor model and combined model were built using 5-fold cross-validation. And it was further tested on the independent cohort. Discrimination was assessed by using the C-index and area under the receiver operating characteristic curve (AUC), sensibility, specificity.

A Radiomic Model for Risk of Local Recurrence and DFS for T3 and T4 Non-small Cell Lung Cancer

Development of a Tumor and Peritumor Radiomics-based Model to Predict the High-risk Surgical Margin and Prognosis of T3 and T4 Non-Small Cell Lung Cancer

the time from the surgery time to the recurrence time

Jinling Hospital, China

Director of the Medical Imaging Center of the Jinling Hospital

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
A Radiomic Model for Risk of Local Recurrence and DFS for T3 and T4 Non-small Cell Lung Cancer	NCT06405815	Lung Cancer, No...	tumor and perit...	18 Years -	Jinling Hospital, China
A Radiomic Model for Risk of Local Recurrence and DFS for T3 and T4 Non-small Cell Lung Cancer	NCT06405815	Lung Cancer, No...	tumor and perit...	18 Years -	Jinling Hospital, China

Spots Global Cancer Trial Database for tumor and peritumor radiomic feature