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Tegafur

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Iressa 250 mg daily treatment plus UFUR twice daily treatment

UFUR and Iressa

Yuh-Min Chen, MD, PhD.

Iressa \[epidermal growth factor tyrosine kinase inhibitor (EGFR-TKI)\] has been reported to activity against Non-small-cell Lung Cancer (NSCLC) failed previous chemotherapy. UFUR was found to have anti-angiogenesis effect when long term treatment was given. Combination of EGFR-TKI and anti-angiogenesis agents is a novel treatment.

Iressa is a selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). It is an orally active agent for advanced non-small-cell lung cancer (NSCLC) in those who have failed a previous platinum-based regimen and taxane treatment. UFUR (Tegafur/Uracil) is effective agent against chemo-naïve NSCLC. It has anti-angiogenesis effect when used as long-term low dose treatment.

Present phase II randomized clinical trial is designed to answer whether or not adding an oral anti-angiogenesis agent (UFUR), that has low toxicity profiles when long term use, to EGFR-TKI (Iressa) could increase patients survival and response rate.

UFUR (Tegafur/Uracil) Plus Iressa in Non-small-cell Lung Cancer

Phase II Trial of Adding UFUR to Non-small-cell Lung Cancer Patients Treated With Iressa

Taipei Veterans General Hospital, Taiwan

Yuh-Min Chen, MD, PhD, Associate Professor

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
UFUR (Tegafur/Uracil) Plus Iressa in Non-small-cell Lung Cancer	NCT01037998	Non-Small-Cell ...	UFUR and Iressa	18 Years -	Taipei Veterans General Hospital, Taiwan
UFUR (Tegafur/Uracil) Plus Iressa in Non-small-cell Lung Cancer	NCT01037998	Non-Small-Cell ...	UFUR and Iressa	18 Years -	Taipei Veterans General Hospital, Taiwan

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