Neoplasms

All Conditions

Gland and Hormone Related Diseases

Rare Diseases

Adenoma

Hyperparathyroidism

Hyperparathyroidism, Primary

Parathyroid Neoplasms

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Endocrine Gland Neoplasms

Head and Neck Neoplasms

Endocrine System Diseases

Parathyroid Diseases

Primary Hyperparathyroidism

All Drugs and Chemicals

Bone Density Conservation Agents

Hormones

Calcium

Calcium, Dietary

Parathyroid Hormone

One High Intensity focused ultrasound session before surgery. Use of appropriate energy for each patient

Ultrasonic ablation device

Philippe BONNICHON, MD

This study is a multicentre, open, uncontrolled trial for the observation of histological changes in parathyroid adenomas following high intensity focused ultrasound (HIFU).

This study will be conducted in France in 10 patients with primary hyperparathyroidism scheduled for a parathyroidectomy. The patient will receive an HIFU treatment in the center of the adenoma before the surgery.

Observation of Histological Changes in Parathyroid Adenomas Following High Intensity Focused Ultrasound (HIFU) Treatment Procedure

Observation of Histological Changes in Parathyroid Adenomas Following High Intensity Focused Ultrasound (HIFU)Treatment Procedure: A Monocentre, Open, Uncontrolled Study

Theraclion

Skin and Connective Tissue Diseases

Fibroadenoma

Neoplasms, Fibrous Tissue

Neoplasms, Connective Tissue

Neoplasms, Connective and Soft Tissue

High Intensity focused ultrasound treatment

Loïc BOULANGER, MD

This study is a multicentre, open, uncontrolled trial for the observation of histological changes in breast fibroadenoma following high intensity focused ultrasound (HIFU).

This study will be conducted in France in 20 patients with breast fibroadenoma with indication for a surgical resection. The patient will receive an HIFU treatment and 6 months after treatment, the need of the surgery is evaluated.

High Intensity Focused Ultrasound (HIFU) to Treat Breast Fibroadenoma

High Intensity Focused Ultrasound (HIFU) to Treat Breast Fibroadenoma: a Feasibility Study. A Multicentric, Open, Uncontrolled Study

reduction in volume at 2, 4, 6 and 12 months after HIFU session or total regression of the fibroadenoma evaluated with ultrasound just before surgery

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Symptoms and General Pathology

Kidney Diseases

Kidney Failure, Chronic

Neoplasm Metastasis

Hyperparathyroidism, Secondary

Hyperplasia

Renal Insufficiency

Neoplastic Processes

Urologic Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Male Urogenital Diseases

Renal Insufficiency, Chronic

Chronic Disease

Disease Attributes

Chronic Graft Versus Host Disease

High Intensity Focused Ultrasound treatment

Angel Luis Martin DE FRANCISCO, Pr

Secondary hyperparathyroidism (sHPT) is common in patients with chronic kidney disease (CKD), including those who are undergoing long-term haemodialysis treatment. sHPT is characterized by persistently elevated levels of parathyroid hormone (PTH) and major disturbances in phosphorus and calcium metabolism. When glomerular filtration rate (GFR) falls, the phosphorus clearance decreases significantly, leading to phosphorus retention. The resulting hyperphosphatemia is thought to be one of the principal causes of secondary hyperparathyroidism which is a very early complication of patients with CKD. Its diagnosis and treatment is crucial in the management of such patients.The treatment of the sHPT of CKD's patient includes dietary phosphate restriction, the use of phosphate binders, correction of hypocalcaemia, the use of vitamin D and its derivatives. The calcimimetic agent cinacalcet hydrochloride may be also used in combination with vitamin D. While the majority of patients can be controlled in this way, medical therapy is not always successful in achieving adequate control of secondary hyperparathyroidism. Oral medications (calcimimetics, recently developed phosphate binders, and active vitamin D derivatives amount to very high monthly costs, and have efficacy limitations as well as side-effects.

HIFU may become a valuable alternative treatment that help control secondary hyperparathyroidism in selected patients presenting with enlarged parathyroid gland(s) visible at ultrasonography,.

The aim of this study is to evaluate the efficacy and safety of HIFU treatment in chronic haemodialysis patients with secondary hyperparathyroidism presenting with enlarged parathyroid gland(s) which are visible at ultrasonography and for whom medical therapy has been unsuccessful.

Efficacy and Safety of High Intensity Focused Ultrasound (HIFU) Device to Treat Secondary Hyperparathyroidism

Efficacy and Safety of High Intensity Focused Ultrasound (HIFU) Device to Treat Uncontrolled Secondary Hyperparathyroidism in Chronic Haemodialysis Patients

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Observation of Histological Changes in Parathyroid Adenomas Following High Intensity Focused Ultrasound (HIFU) Treatment Procedure	NCT01060982	Primary Parathy...	Ultrasonic abla...	18 Years -	Theraclion
High Intensity Focused Ultrasound (HIFU) to Treat Breast Fibroadenoma	NCT01422629	Breast Fibroade...	Ultrasonic abla...	18 Years -	Theraclion
High Intensity Focused Ultrasound (HIFU) to Treat Breast Fibroadenoma	NCT01422629	Breast Fibroade...	Ultrasonic abla...	18 Years -	Theraclion
Efficacy and Safety of High Intensity Focused Ultrasound (HIFU) Device to Treat Secondary Hyperparathyroidism	NCT01421407	Secondary Hyper... End Stage Renal... Parathyroid Hyp...	Ultrasonic abla...	18 Years -	Theraclion

Spots Global Cancer Trial Database for ultrasonic ablation device