Neoplasms

Skin and Connective Tissue Diseases

All Conditions

Skin Neoplasms

Micronutrients

All Drugs and Chemicals

Bone Density Conservation Agents

Vitamins

Vitamin D

Cholecalciferol

Vitamin D3

Calciferol

Hans Christian Wulf, Professor

The purpose of the study is to determine the importance of the UV intensity and the UVB dose on the Vitamin D response after UVB.

The work is addressing vitamin D production after UVB exposure and explore the importance of UVB dose and UV intensity. Four different UVB doses and four different UV intensities are used to explore these relationships.

Many assumptions have been made concerning the vitamin D production after UVB exposure but only few studies exist.

The Vitamin D Dose-Response Relationship

Vitamin D Production Depends on Ultraviolet-B Dose But Not on UV-intensity. A Randomized Controlled Trial

Vitamin D measured in a blood sample to define the dose-response relationship between UVB dose, UV intensity and Vitamin D production in the skin after UVB exposure.

To invesitage whether other parameters like sex, BMI, Diet etc. influences the vitamin D production after UVB exposure.

The Danish Medical Research Council

Bispebjerg Hospital

Morten Bogh MD

Infections

Blood and Lymph Conditions

Immune System Diseases

Diseases and Abnormalities at or Before Birth

Symptoms and General Pathology

Rare Diseases

Dermatitis

Mycoses

Mycosis Fungoides

Psoriasis

Dermatitis, Atopic

Eczema

Skin Diseases

Alopecia

Alopecia Areata

Urticaria

Striae Distensae

Skin Diseases, Papulosquamous

Skin Diseases, Genetic

Genetic Diseases, Inborn

Skin Diseases, Eczematous

Hypersensitivity

Hypersensitivity, Immediate

Hypotrichosis

Hair Diseases

Pathological Conditions, Anatomical

Bacterial Infections

Communicable Diseases

Bacterial Infections and Mycoses

Lymphoma

Lymphoma, T-Cell

Lymphoma, T-Cell, Cutaneous

Lymphoma, Non-Hodgkin

Neoplasms by Histologic Type

Lymphoproliferative Disorders

Lymphatic Diseases

Immunoproliferative Disorders

Skin Diseases, Vascular

Skin Manifestations

Lymphosarcoma

UVA 1 Irradiation (Sellemed UVA1 light source) up to 130 J/cm2

UVB Irradiation maximum dose of 4000 mJ/cm2

The affected areas on the body will be treated with UVA1 (Sellemed UVA1 light source) for up to 5 times per week for 16 weeks. The UVA1 dose will be up to 130 J/cm2.

UVA1 Irradiation

The affected areas on the body will be treated with UVB light for up to 5 times per week for 16 weeks. The maximum UVB dose will be 4000 mJ/cm2.

UVB Irradiation

John J Voorhees, MD

The purpose of this investigation is to study the effectiveness of longer wavelength UVA1 (340-400nm) or shorter wavelength ultraviolet B \[UVB\] (290-320nm) irradiation in the treatment of inflammatory skin conditions (such as: atopic dermatitis, psoriasis, mycosis fungoides, alopecia areata, stretch marks and urticaria).

This research study aims to evaluate the effectiveness of an investigational device which is similar in appearance to a "tanning bed" but which emits ultraviolet irradiation of a specific wavelength known as UVA1. This device has not been approved by the Food and Drug Administration (FDA) for general use in this country, as of yet, but it has been used quite successfully in Europe for several years in treating such conditions as scleroderma, atopic dermatitis, urticaria pigmentosa and other skin conditions.

Instead of UVA1 therapy, patients may receive ultraviolet radiation of a specific wavelength known as UVB. UVA1 light is a longer wavelength and therefore a lower energy wavelength than UVB. UVB light is often the light associated with getting a sunburn since it has a higher level of energy. UVB light has been used successfully in the treatment of many skin conditions.

The purpose of this investigation is to study the effectiveness of longer wavelength UVA1 (340-400nm) or shorter wavelength UVB (290-320nm) irradiation in the treatment of inflammatory skin conditions. Inflammatory dermatoses refer to conditions like atopic dermatitis (eczema) and psoriasis in which circulating leukocytes (T cells, neutrophils, and monocytes) infiltrate the skin. The infiltrating cells may be of malignant phenotype as in mycosis fungoides (cutaneous T cell lymphoma-CTCL). Up to 50 patients with one of these diagnoses or related conditions will participate in this study. The affected areas on the body will be treated with UVA1 or UVB for up to 5 times per week for 16 weeks. The UVA1 dose will be up to 130 J/cm2. The maximum UVB dose will be 4000 mJ/cm2. This UVA1 dosing schedule has been safely used in Germany for treating patients with atopic dermatitis, mycosis fungoides, granuloma annulare, scleroderma, and urticaria pigmentosa. Subjects will be evaluated clinically at baseline, weeks 1, 2, 4, and then at monthly intervals. More frequent evaluation may be required depending on the condition being studied. Paired skin biopsies may be taken from involved and uninvolved (or treated and untreated) areas before and during UV therapy.

Ultraviolet (UVA and UVB) Light Therapy in the Treatment of Inflammatory Skin Conditions

The Effectiveness of UVA1 and UVB Irradiation in the Treatment of Inflammatory Dermatoses: An Open Pilot Study

University of Michigan

Assistant Professor of Dermatology, Medical School

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
The Vitamin D Dose-Response Relationship	NCT01074541	Vitamin D Statu...	UVB UVB UVB UVB	18 Years - 65 Years	Bispebjerg Hospital
Ultraviolet (UVA and UVB) Light Therapy in the Treatment of Inflammatory Skin Conditions	NCT00129415	Atopic Dermatit... Psoriasis Alopecia Mycosis Fungoid... Urticaria Dermatoses Stretch Marks	UVA1 Irradiatio... UVB Irradiation	10 Years - 80 Years	University of Michigan
The Vitamin D Dose-Response Relationship	NCT01074541	Vitamin D Statu...	UVB UVB UVB UVB	18 Years - 65 Years	Bispebjerg Hospital

Spots Global Cancer Trial Database for uvb

Every month we try and update this database with for uvb cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for uvb

Every month we try and update this database with for uvb cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for uvb cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.