Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Carcinoma, Non-Small-Cell Lung

Lung Neoplasms

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

a minimal invasive surgical types for NSCLC: VATS lobectomy

VATS lobectomy

a minimal invasive surgical types for NSCLC: RATS lobectomy

RATS lobectomy

He-Cheng Li, doctor

Robot-assisted thoracoscopic surgery (RATS) was widely used in thoracic surgery, the surgical safety and feasibility of RATS lobectomy for NSCLC has been confirmed. However, the oncological long-term outcomes of RATS lobectomy has not been studied by randomized controlled trial, the purpose of this study is to determine whether RATS lobectomy would be as effective as VATS lobectomy on short-term and long-term outcomes.

Video-assisted thoracoscopic surgery (VATS) lobectomy is recommended for non small cell lung cancer (NSCLC) with surgical indications in China, its oncological long-term outcomes has been widely approved. As a new form of VATS, robot-assisted thoracoscopic surgery (RATS) was widely used in thoracic surgery, the 3D vision and flexible robot arm were helpful for surgeons to perform precise operations, and RATS was reported to bring extra benefits to patients. The surgical safety and feasibility of RATS lobectomy for NSCLC has been confirmed. However, the oncological long-term outcomes of RATS lobectomy has not been studied by randomized controlled trial. so we designed this randomized controlled trial to determine whether RATS lobectomy would be as effective as VATS lobectomy on short-term and long-term outcomes.

Robot-assisted vs VATS Lobectomy for NSCLC

The Study of Robotic-assisted Thoracoscopic Lobectomy Versus Video-assisted Thoracoscopic Lobectomy for Non-small Cell Lung Cancer (RVlob)

overall lymph node counts, number of stations dissected, and number of lymph nodes in each lymph node station

the rate of conversion to open surgery in the operation

mainly include: pneumonia, arrhythmia, incision infection, vocal cord paralysis, trachea cannula

Ruijin Hospital

Professor

Symptoms and General Pathology

Pain

A pilot study to observe satisfaction of analgesia with intercostal catheters after VATS lobectomy.

Pain and satisfaction with pain treatment is investigated in a population after VATS lobectomy.

Inter Costal Catheters for Video-Assisted Thoroscopic (VATS) Lobectomy

Pain Relief After VATS Lobectomy Using Interoperatively Placed Inter Costal Catheters.

Daily presence of, Nausea Dizziness Vomiting Sedation Pruritus

Dept. of thoracic Surgery

Dept. of cardio-thoracic anaesthesia

Dept. Surgical PAthophysiology

all Blegdamsvej 9, 2100-Copenhagen, Denmark

Rigshospitalet, Denmark

MD Kim Wildgaard

Andrea Imperatori, MD

A five classes (A-E) aggregate risk score predicting 90-day mortality after video-assisted thoracoscopic lobectomy for lung cancer, including as independent factors male sex (3 points), carbon monoxide lung diffusion capacity \<60% (1 point) and operative time \>150 minutes (1 point), has been recently published. This study aims to assess the effectiveness and reliability of this risk model in a large, independent cohort of patients, in order to confirm its generalizability.

From the Italian VATS Group Database, we selected patients who underwent video-assisted thoracoscopic lobectomy for non-small cell lung cancer. We calculated the aggregate risk score and the corresponding class of 90-day mortality risk for each patient. The correlation between risk classes and mortality rates was tested by Spearman's rho-test. Model calibration was evaluated by Hosmer-Lemeshow goodness-of-fit test.

Assessment of the 90-day Mortality Risk Score After VATS Lobectomy

Assessment of the 90-day Mortality Risk Score After Video-assisted Thoracoscopic Lobectomy in the Italian VATS Group Cohort

Università degli Studi dell'Insubria

Principal Investigator - Clinician at Center for Thoracic Surgery - School of Medicine and Surgery - University of Insubria - Varese

Nervous System Diseases

Behaviors and Mental Disorders

Alzheimer Disease

Carcinoma

Carcinoma, Bronchogenic

Bronchial Neoplasms

Pathologic N2 NSCLC patients who received lobectomy by video-assisted thoracoscopic surgery

Pathologic N2 NSCLC patients who received lobectomy by thoracotomy

Patients who received lobectomy by video-assisted thoracoscopic surgery

Patients who received lobectomy by thoracotomy

Thoracotomy lobectomy

Xiaofei Li, PhD

The study was designed to compare the safety and effectiveness of vedio-assisted thoracoscopic lobectomy with open lobectomy for patients with surgically resectable pathologic N2 non-small cell lung cancer

The is a multi-center retrospective study. Patients with pathologic N2 NSCLC who underwent VATS or open lobectomy between 2014 and 2017 were included into this study. Clinical data on patient demographic, clinical characteristics, treatment and clinical outcomes will be collected to evaluate the safety and effectiveness of video-assisted thoracoscopic lobectomy for pathologic N2 NSCLC.

Is Video-assisted Thoracoscopic Lobectomy a Clinical Alternative for Surgically Resectable Pathologic N2 NSCLC Patients

Vedio-assisted Thoracoscopic Lobectomy vs Open Lobectomy for Patients With Surgically Resectable Pathologic N2 NSCLC

Overall survivals in the subgroups stratified by T staging

Overall survivals in the subgroups stratified by neoadjuvant therapy

Overall survivals in the subgroups stratified by number of lymph node station involved

Impact factors for postoperative mortality within 30/90 days

Propensity score matching analysis of overall survival

Propensity score matching analysis of perioperative outcomes

Propensity score matching analysis of impact factors for overall survival

Propensity score matching analysis of impact factors for postoperative mortality within 30/90 days

Duration of hospital stay \[Perioperative outcomes\]

Postoperative 30 and 90 days \[Perioperative outcomes\]

Intraoperative blood loss \[Perioperative outcomes\]

Postoperative complications \[Perioperative outcomes\]

LinkDoc Technology (Beijing) Co. Ltd.

Tang-Du Hospital

Lobectomy and mediastinal lymph node dissection by thoracotomy with rib-spreading.

Thoracoscopic minimally invasive lobectomy with thoracoscopic mediastinal lymph node dissection without rib-spreading.

Robot-assisted lobectomy with mediastinal lymph node dissection (Robot group as clinical assignment in prospective Cohort).

OPEN lobectomy

ROBOT-assisted lobectomy

Thomas J van Brakel, MD, PhD

A. Verhagen, MD

A. Verhagen Verhagen, MD

T. van Brakel, MD, PhD

In patients with early stage lung cancer surgical lobectomy is the treatment of choice. A resection by Video-assisted Thoracic Surgery (VATS) is probably superior to an open procedure by thoracotomy for patients with early stage lung cancer, but randomized evidence for superiority is lacking. Furthermore, VATS lobectomy has not gained broad implementation yet. The objective of this study is to assess the benefits of VATS- over open lobectomy regarding quality of life and costs in a prospective randomized controlled multicenter trial. All patients meeting the inclusion criteria that are not randomized will be included in a prospective Cohort.

Rationale: Surgical lobectomy is the treatment of choice for patients with early stage lung cancer. In some centres, video-assisted thoracic surgery (VATS) lobectomy is preferred, where other centres hold on to the conventional open lobectomy via a thoracotomy. Although several studies have demonstrated fewer postoperative complications and shorter hospital length of stay for the VATS procedure, others have reported concerns regarding oncologic equivalence, mainly based on incomplete lymph node staging. Convincing randomized evidence from the literature is lacking. The aim of this randomized multicentre study is to compare quality of life, oncologic endpoints and cost-effectiveness between VATS- and open (thoracotomy) lobectomy.

Objective: To compare quality of life, cost-effectiveness and number of dissected mediastinal lymph nodes between open,VATS and ROBOT-assisted lobectomy.

Study design: A prospective multi-centre randomized trial with a prospective registry arm Study population: Adult patients of either gender, selected by the pulmonary oncological multidisciplinary team to undergo surgical lobectomy for early-stage lung carcinoma.

Intervention: One group is assigned to the open procedure: posterolateral thoracotomy for lobectomy with mediastinal lymph node dissection. The other group is assigned to the VATS procedure: thoracoscopic minimally invasive lobectomy with thoracoscopic mediastinal lymph node dissection. All patients that do meet the inclusion criteria but are not participating in the randomized trial can be included in the prospective Cohort arm of the study evaluating clinical assignment to OPEN- VATS or ROBOT-assisted lobectomy.

Main study parameters/endpoints: Primary endpoints are postoperative quality of life, and hospital length of stay. Secondary endpoints include cancer specific quality of life, number of dissected mediastinal lymph nodes and stations, procedural complication rates, pulmonary function, overall costs and survival.

Centres participating in this study currently perform the open- and VATS and/or ROBOT-assisted lobectomy in daily clinical practice.

Treatment of Early Stage Lung Cancer by VATS Versus OPEN Lobectomy

thoracoSCopic Versus OPen Lobectomy for Early Stage Lung Cancer: a Randomized Prospective Trial

Primary endpoints include Quality of life assessed by EQ5D for VATS versus open lobectomy in patients with early stage non small cell lung carcinoma.

The number of intraoperatively dissected mediastinal lymphnode stations is assessed as a secondary oncologic outcome measure.

This secondary composite endpoints include conversion rate, bleeding, air leakage, pain, cardiac arrhythmias, wound infection, pulmonary complications, pulmonary function.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Robot-assisted vs VATS Lobectomy for NSCLC	NCT03134534	Pulmonary Neopl...	VATS lobectomy RATS lobectomy	18 Years - 80 Years	Ruijin Hospital
Inter Costal Catheters for Video-Assisted Thoroscopic (VATS) Lobectomy	NCT01213654	Lung Cancer Pat...		18 Years -	Rigshospitalet, Denmark
Assessment of the 90-day Mortality Risk Score After VATS Lobectomy	NCT04799509	Lung Cancer Surgery--Compli... Morality	VATS lobectomy	-	Università degli Studi dell'Insubria
Inter Costal Catheters for Video-Assisted Thoroscopic (VATS) Lobectomy	NCT01213654	Lung Cancer Pat...		18 Years -	Rigshospitalet, Denmark
Is Video-assisted Thoracoscopic Lobectomy a Clinical Alternative for Surgically Resectable Pathologic N2 NSCLC Patients	NCT03613467	Non-small Cell ...	VATS lobectomy Thoracotomy lob...	18 Years -	Tang-Du Hospital
Treatment of Early Stage Lung Cancer by VATS Versus OPEN Lobectomy	NCT01933828	Lung Cancer	OPEN lobectomy VATS lobectomy ROBOT-assisted ...	18 Years -	Radboud University Medical Center
Is Video-assisted Thoracoscopic Lobectomy a Clinical Alternative for Surgically Resectable Pathologic N2 NSCLC Patients	NCT03613467	Non-small Cell ...	VATS lobectomy Thoracotomy lob...	18 Years -	Tang-Du Hospital
Is Video-assisted Thoracoscopic Lobectomy a Clinical Alternative for Surgically Resectable Pathologic N2 NSCLC Patients	NCT03613467	Non-small Cell ...	VATS lobectomy Thoracotomy lob...	18 Years -	Tang-Du Hospital

Spots Global Cancer Trial Database for vats lobectomy