Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Prostatic Neoplasms

Genital Neoplasms, Male

Urogenital Neoplasms

Genital Diseases

Genital Diseases, Male

Urogenital Diseases

Prostatic Diseases

Male Urogenital Diseases

Anticonvulsants

Central Nervous System Depressants

All Drugs and Chemicals

Phenobarbital

Hypnotics and Sedatives

Excitatory Amino Acid Antagonists

Neurotransmitter Agents

GABA Modulators

VERDICT MRI

Luminal Index Imaging

Joey Clemente

Shonit Punwani

Multiparametric magnetic resonance imaging (mpMRI) is now widely used to risk stratify men with a suspicion of prostate cancer and identify suspicious regions for biopsy. Advanced MRI techniques have emerged which seek to improve this characterisation and could predict biopsy results non-invasively before men undergo biopsy. Before these techniques are translated clinically, robust histological and clinical validation is required.

This study aims to clinically validate advanced MRI techniques in a cohort of men suspected with prostate cancer. Histological analysis of men undergoing biopsy, +/- prostatectomy will be used for biological validation of VERDICT; Vascular and Extracellular Restricted Diffusion for Cytometry in Tumours and Luminal Water imaging (LWI). In particular, prostatectomy specimens will be processed using 3-D printed patient-specific moulds to allow for accurate MRI and histology mapping.

Participant eligibility is based on self-representation of gender identity. Men with clinical suspicion of prostate cancer.

Learning MRI and Histology Image Mappings for Cancer Diagnosis and Prognosis.

Learning MRI and Histology Image Mappings for Cancer Diagnosis and Prognosis

Number of correct predictions of gleason grade in men who undergo biopsy or prostatectomy.

Quantitative assessment of VERDICT MRI reduces false positives by 10% compared to standard MRI alone

Quantitative assessment of LWI reduces false positives by 10% compared to standard MRI alone

University College, London

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Learning MRI and Histology Image Mappings for Cancer Diagnosis and Prognosis.	NCT04792138	Prostate Cancer Prostate Neopla...	VERDICT MRI Luminal Index I...	18 Years - 90 Years	University College, London
Learning MRI and Histology Image Mappings for Cancer Diagnosis and Prognosis.	NCT04792138	Prostate Cancer Prostate Neopla...	VERDICT MRI Luminal Index I...	18 Years - 90 Years	University College, London

Spots Global Cancer Trial Database for verdict mri

Every month we try and update this database with for verdict mri cancer trials from around the world to help patients and their families find trials that might be right for them.
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Spots Global Cancer Trial Database for verdict mri

Every month we try and update this database with for verdict mri cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for verdict mri cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.