Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

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Symptoms and General Pathology

Lung Neoplasms

Neoplastic Cells, Circulating

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Neoplasm Metastasis

Neoplastic Processes

During this procedure, patients undergo lobectomy with the pulmonary vein ligated first.

During this procedure, patients undergo lobectomy with the pulmonary artery ligated first.

Vein ligation first

Artery ligation first

Lunxu Liu, M.D.,Ph.D.

The purpose of this study is to assess the impact of the sequence of vessel interruption in lung cancer patients on tumor cell spread and patient survival by using peripheral blood circulating tumor cells.

Circulating tumor cells (CTCs) in the peripheral blood can be a biomarker to predict tumor recurrence and survival. Handling the tumor during a surgery may promote the release of CTCs into the bloodstream. Therefore, in a surgery of cancer, interruption of the vein before ligation of the artery may be justified. This multi-center randomized controlled trial is to assess the impact of the sequence of vessel interruption in lung cancer patients on tumor cell spread and patient survival by using peripheral blood CTCs.

Reduced Dissemination of Tumor Cells With Primary Ligation of the Vein in Patients With Lung Cancer

Reduced Dissemination of Tumor Cells With Primary Ligation of the Vein in Patients With Lung Cancer: A Multi-centre Randomized Controlled Trial

The changes of the level of circulating tumor cells in the peripheral blood before cutting the skin and after closing the chest

From the date of recruitment until the date of progression of lung cancer assessed up to 36 months

The length of patients staying in hospital from the date of checking in to the date of checking out

Complications resulting from surgery, such as pneumonia, air leak and arrhythmia.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Reduced Dissemination of Tumor Cells With Primary Ligation of the Vein in Patients With Lung Cancer	NCT03436329	Lung Cancer Surgery Circulating Tum...	Vein ligation f... Artery ligation...	18 Years - 80 Years	West China Hospital
Reduced Dissemination of Tumor Cells With Primary Ligation of the Vein in Patients With Lung Cancer	NCT03436329	Lung Cancer Surgery Circulating Tum...	Vein ligation f... Artery ligation...	18 Years - 80 Years	West China Hospital
Reduced Dissemination of Tumor Cells With Primary Ligation of the Vein in Patients With Lung Cancer	NCT03436329	Lung Cancer Surgery Circulating Tum...	Vein ligation f... Artery ligation...	18 Years - 80 Years	West China Hospital

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