Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Symptoms and General Pathology

Lung Neoplasms

Neoplastic Cells, Circulating

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Neoplasm Metastasis

Neoplastic Processes

During this procedure, patients undergo lobectomy with the pulmonary vein ligated first.

During this procedure, patients undergo lobectomy with the pulmonary artery ligated first.

Vein ligation first

Artery ligation first

Lunxu Liu, M.D.,Ph.D.

The purpose of this study is to assess the impact of the sequence of vessel interruption in lung cancer patients on tumor cell spread and patient survival by using peripheral blood circulating tumor cells.

Circulating tumor cells (CTCs) in the peripheral blood can be a biomarker to predict tumor recurrence and survival. Handling the tumor during a surgery may promote the release of CTCs into the bloodstream. Therefore, in a surgery of cancer, interruption of the vein before ligation of the artery may be justified. This multi-center randomized controlled trial is to assess the impact of the sequence of vessel interruption in lung cancer patients on tumor cell spread and patient survival by using peripheral blood CTCs.

Reduced Dissemination of Tumor Cells With Primary Ligation of the Vein in Patients With Lung Cancer

Reduced Dissemination of Tumor Cells With Primary Ligation of the Vein in Patients With Lung Cancer: A Multi-centre Randomized Controlled Trial

The changes of the level of circulating tumor cells in the peripheral blood before cutting the skin and after closing the chest

From the date of recruitment until the date of progression of lung cancer assessed up to 36 months

The length of patients staying in hospital from the date of checking in to the date of checking out

Complications resulting from surgery, such as pneumonia, air leak and arrhythmia.

West China Hospital

Professor

Digestive System Diseases

Rectal Neoplasms

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Intestinal Diseases

Rectal Diseases

During this procedure, patients undergo laparoscopic rectal cancer surgery with the inferior mesenteric vein ligated first.

During this procedure, patients undergo laparoscopic rectal cancer surgery with the inferior mesenteric artery ligated first.

Tao Pan, Doctor

Chao Liu, Professor

Effect of ligation sequence of the inferior mesenteric artery and vein on circulating tumor cells and survival in laparoscopic rectal cancer surgery: a prospective, multicenter, randomized controlled study (ARVECTS)

Several studies have demonstrated that the presence of circulating tumor cells (CTCs) in the peripheral blood can be a surrogate biomarker to predict recurrence and prognosis of rectal cancer. CTCs are released from the primary tumor into the bloodstream and have the potential to spread to distant sites and develop into micro-metastatic deposits. Numerous studies have demonstrated that surgical manipulation could promote the dissemination of tumor cells into the circulation. Theoretically, the potential risk of tumor cell dissemination can theoretically be minimized if the effluent vein was ligated first. However, there is no regulation in the current guidelines on the sequence of ligation of the inferior mesenteric artery and vein during rectal cancer surgery owing to a lack of sufficient evidence. This multi-center randomized controlled trial is to investigate effect of ligation sequence of the inferior mesenteric artery and vein on circulating tumor cells and survival in laparoscopic rectal cancer surgery

Reduced Dissemination of Tumor Cells With Primary Ligation of the Inferior Mesenteric Vein in Rectal Cancer Patients.

Effect of Ligation Sequence of the Inferior Mesenteric Artery and Vein on Circulating Tumor Cells and Survival in Laparoscopic Rectal Cancer Surgery: a Prospective, Multicenter, Randomized Controlled Study (ARVECTS)

The changes of the level of circulating tumor cells in the peripheral blood before cutting the skin and after closing the abdomen

The proportion of patients with no disease recurrence and metastasis after 3 years of surgery

The proportion of patients who survived 3 years after surgery

Recurrence patterns are classified into five categories at the time of first diagnosis: locoregional, hematogenous, peritoneal, distant lymph node, and mixed type

The intraoperative morbidity rates are defined as the rates of event observed within operation

This is for the early postoperative complication, which defined as the event observed within 30 days after surgery

Time to first ambulation, flatus, liquid diet and soft diet, duration of postoperative hospital stay and postoperative pain are used to assess the postoperative recovery course.Visual analog pain score method is used to evaluate the difference of postoperative pain degree

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Reduced Dissemination of Tumor Cells With Primary Ligation of the Vein in Patients With Lung Cancer	NCT03436329	Lung Cancer Surgery Circulating Tum...	Vein ligation f... Artery ligation...	18 Years - 80 Years	West China Hospital
Reduced Dissemination of Tumor Cells With Primary Ligation of the Vein in Patients With Lung Cancer	NCT03436329	Lung Cancer Surgery Circulating Tum...	Vein ligation f... Artery ligation...	18 Years - 80 Years	West China Hospital
Reduced Dissemination of Tumor Cells With Primary Ligation of the Inferior Mesenteric Vein in Rectal Cancer Patients.	NCT05807646	Rectal Cancer	Vein ligation f... Artery ligation...	18 Years - 75 Years	Sichuan Cancer Hospital and Research Institute
Reduced Dissemination of Tumor Cells With Primary Ligation of the Vein in Patients With Lung Cancer	NCT03436329	Lung Cancer Surgery Circulating Tum...	Vein ligation f... Artery ligation...	18 Years - 80 Years	West China Hospital
Reduced Dissemination of Tumor Cells With Primary Ligation of the Inferior Mesenteric Vein in Rectal Cancer Patients.	NCT05807646	Rectal Cancer	Vein ligation f... Artery ligation...	18 Years - 75 Years	Sichuan Cancer Hospital and Research Institute

Spots Global Cancer Trial Database for vein ligation first