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Vitamin C

The study group will receive intravenous high-dose vitamin C 30 gm in 500 ml normal saline in 1-hour infusion, once per week, and total 4-week treatment.

The control group will receive 500 ml normal saline in 1-hour infusion, once per week, and total 4-week treatment.

High-dose vitamin C 30 gm in 500 ml normal saline, once per week, and total 4-week treatment.

high-dose vitamin C 30gm

500ml normal saline, once per week, and total 4-week treatment

normal saline

Chin-Ying Chen, MD, MHSc

Chin-Ying Chen

This study determines whether high dose vitamin C is effective for quality of life in terminal cancer patients.

The investigator's project is a single medical center, randomized double- blinded trial. The target group is terminal cancer patients at Palliative care clinics. The experimental group will receive intravenous high-dose vitamin C 30 g in 500 ml normal saline in 1-hour infusion, once per week, and total 4-week treatment. The control group will receive 500 ml normal saline in 1-hour infusion, once per week, and total 4-week treatment. The primary outcome is the improvement of quality of life, measured by European Organization for Research and Treatment of cancer (EORTC). The secondary outcome is the survival analysis.The participants will be followed up weekly for 2 weeks, then bi-weekly for 6 months.

Parallel Assignment Randomized double-blinded controlled trial

The Effect of Vitamin C on Quality of Life of Terminal Cancer Patients

QOL measured by European Organization for Research and Treatment of cancer Quality of Life Questionnaire (EORTC QLQ)-C30

death time of those who have completed the 4-week intervention

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
The Effect of Vitamin C on Quality of Life of Terminal Cancer Patients	NCT03224572	Vitamin C Defic...	high-dose vitam... normal saline	20 Years -	National Taiwan University Hospital
The Effect of Vitamin C on Quality of Life of Terminal Cancer Patients	NCT03224572	Vitamin C Defic...	high-dose vitam... normal saline	20 Years -	National Taiwan University Hospital

Spots Global Cancer Trial Database for vitamin c deficiency