Symptoms and General Pathology

All Conditions

Neoplasms

Blood and Lymph Conditions

Rare Diseases

Syndrome

Leukemia

Leukemia, Myeloid

Leukemia, Myeloid, Acute

Preleukemia

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Neoplasms by Histologic Type

Hematologic Diseases

Bone Marrow Diseases

Myeloid Leukemia

Acute Myeloid Leukemia

Acute Non Lymphoblastic Leukemia

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Anti-Infective Agents

Antineoplastic Agents

All Drugs and Chemicals

Cytarabine

Fludarabine

Fludarabine phosphate

Busulfan

Thiotepa

Antimetabolites

Immunosuppressive Agents

Immunologic Factors

Antiviral Agents

Alkylating Agents

Antineoplastic Agents, Alkylating

First Randomisation (closed to recruitment) - control arm: Intermediate dose Cytarabine (1g/m\^2 administered by intravenous infusion over 2 hours on days 1-5 inclusive)

First Randomisation (closed to recruitment) - experimental arm: Vyxeos (29mg/65mg/m\^2 administered by intravenous infusion over 90 minutes on days 1 and 3)

Second Randomisation - under 55 years - control arm: Fludarabine (40mg/m\^2 days -7, -6, -5, and -4), Busulphan (3.2mg/kg days -7, -6, -5 and -4)

Second Randomisation - under 55 years - experimental arm: Thiotepa (5mg/kg day -7 and -6), Busulphan (3.2mg/kg days -5, -4 and -3), Fludarabine (50mg/m\^2 days -5, -4 and -3)

Third Randomisation - 55 years and over (or under 55 with comorbidities) - control arm: Fludarabine (30mg/m\^2 days -6, -5, -4, -3 and -2), Busulphan (3.2mg/kg days -6 and -5)

Third Randomisation - 55 years and over (or under 55 with comorbidities) - experimental arm: Thiotepa (5mg/kg day -6), Busulphan (3.2mg/kg days -5 and -4), Fludarabine (50mg/m\^2 days -5, -4, and -3)

Vyxeos administered by intravenous infusion

Vyxeos

Fludarabine administered by intravenous infusion

Busulphan administered by intravenous infusion

Busulphan

Thiotepa administered by intravenous infusion

Cytarabine administered by intravenous infusion

Charles Craddock, Professor

Treatment options for older adults with Acute Myeloid Leukaemia (AML) and Myelodysplasia (MDS) are limited. Although stem cell transplantation remains one of the most effective treatments it is associated with severe side effects which have until recently prevented its use in older adults. In the last decade the use of reduced intensity transplants has allowed the extension of the potentially curative effect of transplantation to older patients in whom it was previously precluded. Although a major advance such transplants are associated with a high risk of disease relapse particularly in patients with high risk disease.

This study will evaluate new transplant strategies with the aim of improving the outcome of patients with AML and high risk MDS after stem cell transplantation. Three approaches to improve transplant outcome will be studied:

1. Comparing the new pre-transplant consolidation therapy vyxeos with the standard consolidation therapy (Randomisation 1 is now closed to recruitment).
2. Comparing new conditioning therapies in patients under the age of 55 years
3. Comparing new conditioning therapies in patients aged 55 and over

All patients will be followed up for a minimum of 2 years.

This is a randomised, international, phase II/III, multicentre, clinical trial in patients with AML and MDS undergoing allo-SCT. Patients with AML or MDS who fulfil the eligibility criteria will be invited to participate in the trial across centers performing allo-SCT.

Patients will be randomised to treatment based on a minimisation algorithm prepared at the Cancer Research UK Clinical Trials Unit (CRCTU).

Randomisation 1 (R1) (closed to recruitment) will compare the novel consolidation therapy vyxeos with the standard consolidation therapy intermediate dose cytarabine.

Randomisation 2 (R2) will compare the novel conditioning regimen thiotepa/busulphan/fludarabine (TBF) with the standard conditioning therapy fludarabine/busulphan (FB4) in patients aged under 55 years of age.

Randomisation 3 (R3) will compare the novel conditioning regimen mini thiotepa/busulphan/fludarabine (mini TBF) with the standard regimen fludarabine/busulphan (FB2) in patients aged 55 years of age and over (or patients aged under 55 with comorbidities).

A Trial of Treatments to Assess the Effects on Outcome of Adults With AML and MDS Undergoing Allogeneic SCT

An International Randomised Clinical Trial of Therapeutic Interventions to Assess the Effects on Outcome in Adults With Acute Myeloid Leukaemia and High Risk Myelodysplasia Undergoing Allogeneic Stem Cell Transplantation.

Defined as time from entering the relevant randomisation to the relevant question until death from any cause. Patients who are alive at the end of the trial or have been lost to follow up will be censored at their date last seen. For randomisations 2 and 3 this outcome will also be calculated as time from transplantation in order to run a sensitivity analysis.

Change in minimal residual disease status. A patient will be categorised as either MRD status reduction (MRD positive to negative), MRD remain negative, MRD remain positive or MRD progression (MRD negative to positive) - Randomisation 1 only

DFS defined as time from randomisation to the relevant question to the first of relapse or death from any cause. Patients who are alive and disease free at the end of the trial will be censored at their date known to be alive.

CIR defined as time from randomisation to the relevant question to the date of relapse. Patients who die prior to relapse will be treated as a competing risk and patients who are alive and relapse free at the end of the trial will be censored at their date last seen.

NRM defined as the time from randomisation to the relevant question to date of non-relapse death. Patients who die post-relapse will be treated as a competing risk and patients who are alive at the end of the trial will be censored at their date last seen.

The EORTC QLQ-C30 uses for the questions 1 to 28 a 4-point scale. The scale scores from 1 to 4 ("Not at all" to "Very much"). For the raw score, less points are considered to have a better outcome. For the questions 29 and 30 it uses a 7-points scale. The scale scores from 1 to 7 ("very poor" to "excellent"). More points are considered to have a better outcome.

EQ5D is one of the most widely used health states descriptive system. EQ-5D questionnaires have 5 dimensions: "Mobility", "Human Autonomy," "Current Activities", "Pain / Discomfort", "Anxiety / Depression" and all dimensions are described by 3 problem levels corresponding to patient response choices. A quality of life score is obtained according to the answers to the questionnaires.

Incidence of acute and chronic GvHD of any grade - Randomisation 2 and 3 only

Defined as loss of donor cells after transplantation - Randomisation 2 and 3 only

Defined as the number of patients who report one or more adverse event of grade 3 or higher or a serious adverse event of any grade

Jazz Pharmaceuticals

IMPACT (funded by NHS Blood & Transplant, Anthony Nolan and Leukaemia UK)

Adienne SA

University of Birmingham

Amino Acids

Venetoclax

Daunorubicin

Anti-Bacterial Agents

Antibiotics, Antitubercular

Enzyme Inhibitors

Lysine

Venetoclax will be given orally on Days per the assigned dose level. A single course consisting of 3 doses of Vyxeos and 7-21 doses of venetoclax depending on the assigned dose level will be administered to participants in this study. Vyxeos will be administered by central venous catheter over 90 minutes on Day 1, 3, and 5.

Venetoclax is given daily by mouth per assigned dose level.

Vyxeos Dose: daunorubicin 44 mg/m2 and cytarabine 100 mg/m2 administered via intravenous infusion over 90 minutes on Days 1, 3, and 5.

Venetoclax Dose:

1. Dose Level 0 - weight based daily dosing for 21 days
2. Dose Level -1 - weight based daily dosing for 14 days
3. Dose Level -2- weight based daily dosing for 10 days
4. Dose Level -3- weight based daily dosing for 7 days

Site Pulblic Contact

Site Public Contact

John Perentesis, MD

Laura Agresta, MD

This study evaluates the safety and tolerability of combining venetoclax with Vyxeos (CPX-351) in pediatric and young adult patients with acute leukemia that has come back or not responded to treatment.

This is a single-institution Phase I pilot study designed to test the safety and tolerability of combining venetoclax with Vyxeos (CPX-351, cytarabine and daunorubicin liposome) for the treatment of relapsed/refractory acute leukemia in young patients. Subjects will receive a single course of study therapy consisting of daily, oral venetoclax at an assigned dose level with a 3-day ramp-up to target dose and Vyxeos administered intravenously at the established dose on Days 1, 3, and 5. In addition to safety and tolerability, the overall response rate to these therapies will be estimated. Pharmacokinetic (PK) analysis will also be conducted to define the drug clearance of venetoclax in this combination.

Venetoclax Combined With Vyxeos (CPX-351) for Participants With Relapsed or Refractory Acute Leukemia

A Phase I Study of Venetoclax Combined With Vyxeos (CPX-351) for Children, Adolescents and Young Adults With Relapsed or Refractory Acute Leukemia

If 2 or more participants have dose limiting toxicities at a given dose level, the maximum tolerated dose will have been exceeded.

Estimate of overall response rate (ORR) defined as (CR/CRi/CRp).

Children's Hospital Medical Center, Cincinnati

Gemtuzumab

Antineoplastic Agents, Immunological

Immunotoxins

Immunoconjugates

Dose escalation to determine the maximum tolerated dose (MTD) of CPX-351 in combination with Gemtuzumab Ozogamicin in participants with newly diagnosed acute myeloid leukemia. Participants will be treated in cohorts of size three to six and the dosage will be escalated if the clinical toxicity is acceptable. A total of 3 dose levels will be used.

Fixed dose of Vyxeos (44 mg/m2 daunorubicin and 100 mg/m2 cytarabine) (Day 1, 3, and 5) in combination with various dose schedules of Gemtuzumab Ozogamicin (GO)

Participants will be treated at the following dose levels:

Dose Level 1 - Gemtuzumab Ozogamicin will administered 3mg/m2 on Day 1 Dose Level 2 - Gemtuzumab Ozogamicin will administered 3mg/m2 on Day 1 and 4 Dose Level 3 - Gemtuzumab Ozogamicin will administered 3mg/m2 on Day 1, 4, 7

Gemtuzumab Ozogamicin

Lisa Nardelli

Onyee Chan

Onyee Chan, MD

The purpose of the study is to determine the safety of combining the drugs gemtuzumab ozogamicin (GO) with CPX-351 in order to treat the disease, as well as to find the maximum tolerated dose level and recommended Phase 2 dose level of GO with a fixed dose of CPX-351.

CPX-351 in Combination With Gemtuzumab Ozogamicin in Newly Diagnosed AML

A Phase 1/1b Dose Escalation and Expansion of CPX-351 in Combination With Gemtuzumab Ozogamicin in Newly Diagnosed Acute Myeloid Leukemia

Dose escalation will determine the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D) of Vyxeos plus Gemtuzumab Ozogamicin. The MTD is the highest dose of the combination therapy that dose not cause unacceptable side effects.

Rate of complete remission (CR) and complete remission with incomplete blood count recovery (CRi). The definition of CR and CRi is based on the European LeukemiaNet 2017 Response Criteria for AML.

Rate of measurable residual disease via RT-PCR for core binding factor leukemia as well as NPM1 mutated AML

Overall survival is defined as the duration of time from start of treatment to the time of death from any cause or date of last contact.

RFS is defined as time interval between achievement of CR to time of relapse

H. Lee Moffitt Cancer Center and Research Institute

Neoplasm Metastasis

Neoplastic Processes

CPX-351 (cytarabine:daunorubicin) Liposome for Injection is a liposomal formulation of a fixed combination of the antineoplastic drugs cytarabine and daunorubicin. The two drugs are present inside the liposome in a 5:1 molar ratio shown to act synergistically in pre-clinical studies. The liposome membrane is composed of distearoylphosphatidylcholine, distearoylphosphatidylglycerol and cholesterol in a 7:2:1 molar ratio.

CPX-351 is provided as a sterile, pyrogen-free, purple, lyophilized product in 50 mL glass, single-use vials. Each 50 mL vial after reconstitution contains 20 mL of CPX-351 (5 units/mL). Each unit (u) contains 1 mg cytarabine and 0.44 mg daunorubicin base in liposomes suspended in sucrose. Product is stored at 5˚ ± 3PoPC.

CPX-351

This study is a Phase IV Expanded Access Protocol (EAP) of CPX-351 in patients with secondary acute myeloid leukemia who are suitable for treatment with intensive chemotherapy.

The hypothesis that CPX-351 treatment may be safe and efficacious in patients with newly diagnosed secondary AML comes from a single randomized Phase II study which observed significant improvement in survival in a 52-patient subset of patients with secondary AML. A Phase III confirmatory study has recently completed accrual and final results are not expected until mid-2016. Therefore, the sponsor has chosen to make CPX-351 available to secondary AML patients through this expanded access protocol until commercialization of CPX-351 or more information about the clinical utility is known.

This study is a Phase IV multicenter, single-arm open-label Expanded Access Protocol (EAP) of CPX-351 in patients with secondary acute myeloid leukemia who are suitable for treatment with intensive chemotherapy. Patients may receive up to two inductions and four consolidation courses. Patients will be monitored for safety (early deaths, serious adverse events, grade 3 and 4 adverse events, etc.) while on the study and for SAEs for 30 days after the last dose of CPX-351. Study enrollment will be available through commercialization of CPX-351.

EAP of CPX-351 (VYXEOS) for Patients 60-75 Years of Age With Secondary AML

Expanded Access Protocol of CPX-351 (Cytarabine:Daunorubicin) Liposome Injection for Patients 60-75 Years of Age With Secondary AML

Antibodies

Antibodies, Monoclonal

Immunoglobulins

Immunoglobulins, Intravenous

Calicheamicins

Vyxeos (daunorubicin and cytarabine) liposome for injection

Gemtuzumab ozogamicin is an antibody-drug conjugate (ADC) composed of the CD33-directed monoclonal antibody (hP67.6; recombinant humanized immunoglobulin \[Ig\] G4, kappa antibody produced by mammalian cell culture in non-secreting 0 (NS0) cells) that is covalently linked to the cytotoxic agent N-acetyl gamma calicheamicin. Gemtuzumab ozogamicin consists of conjugated and unconjugated gemtuzumab. The conjugated molecules differ in the number of activated calicheamicin derivative moieties attached to gemtuzumab. The number of conjugated calicheamicin derivatives per gemtuzumab molecule ranges from predominantly zero to 6, with an average of 2 to 3 moles of calicheamicin derivative per mole of gemtuzumab.

Mylotarg

Chezi Ganzel, DR

Chezi Ganzel

Vyxeos Vyxeos is a liposomal-encapsulated combination of cytarabine and daunorubicin, at a molar ratio of 5:1. Delivery of the 5:1 molar ratio seems to prevent antagonistic drug-drug interactions and the liposomal encapsulation increases the plasma half-life of cytarabine and daunorubicin and leads to drug accumulation within the bone marrow (BM).

Despite previous results that highlighted the advantage of Vyxeos for sAML, it is intuitively likely that this powerful drug is also suitable for non-sAML. The mechanism of action is relevant for every AML. Following the FDA approval of the drug for sAML we would like to evaluate its efficacy for low or intermediate risk fms-like tyrosine kinase 3 (FLT3)-negative de novo AML patients. This consideration is particularly relevant by the inclusion of young AML patients in the study.

Gemtuzumab ozogamicin (GO) Gemtuzumab ozogamicin (Mylotarg) - an anti-cluster of differentiation 33 (CD33) monoclonal antibody linked to calicheamicin, was approved for the treatment of newly diagnosed AML patients, when given as a combination with the '7+3' regimen.

One of the goals of the current study is to examine the feasibility and efficacy of the combination of Mylotarg plus Vyxeos.

Minimal/ measurable residual disease (MRD) Minimal or measurable residual disease (MRD) denotes the presence of leukemia cells down to levels of 1:10-4 to 1:10-6, compared with 1:20 in morphology-based assessments. MRD can be evaluated using a variety of multiparameter flow cytometry (MFC) and molecular methods. There are no data regarding the achievement or impact of MRD using Vyxeos as induction therapy. The current trial will address this issue.

Purpose of this Trial The current study is designed to examine the response rate of the Vyxeos as induction therapy for newly diagnosed low/intermediate risk AML patients in the 'real world' setting. Patients will receive the same induction therapy that they were to receive had they not entered this study (cytarabine /daunorubicin ± Mylotarg) but the combination of cytarabine /daunorubicin will be given in the unique formulation of Vyxeos. In addition to classic CR+CRi evaluation, MFC MRD evaluation, using an centralized, internationally recognized laboratory, will be done at the end of induction. In addition, this pilot study will also provide clinical safety information about the combination of Vyxeos with Mylotarg.

Introduction Induction therapy Currently, most physicians treating 'fit' patients with acute myeloid leukemia (AML) employ an anthracycline plus cytarabine ('7+3' regimen) as induction therapy. In the past few years 2 new drugs were approved as adjuncts to the '7+3' regimen for treatment of fit patients; Midostaurin- a FLT3 inhibitor and gemtuzumab ozogamicin- an anti-CD33 monoclonal antibody linked to chemotherapy. It has been postulated that using the same drugs as in the '7+3' regimen but at a fixed molar ratio of cytarabine and daunorubicin will increase the CR rate and improve minimal residual disease and disease free survival (DFS).

Vyxeos

Vyxeos is a liposomal-encapsulated combination of cytarabine and daunorubicin, at a molar ratio of 5:1. Delivery of the 5:1 molar ratio seems to prevent antagonistic drug-drug interactions and the liposomal encapsulation increases the plasma half-life of cytarabine and daunorubicin and leads to drug accumulation within the bone marrow (BM). Two randomized controlled trials have been reported in newly diagnosed AML patients:

A phase II, multicenter, randomized, open-label trial studied the efficacy and safety of Vyxeos among newly diagnosed AML patients, age 60-75. The study compared 1-2 induction courses of Vyxeos with '7+3' (daunorubicin dose of 45-60 mg/m2). Patients were allowed to receive 1-2 consolidation courses of Vyxeos (in the investigational arm) and low dose cytarabine with/without daunorubicin or intermediate dose cytarabine (in the control arm). The primary end-point was defined as response rate; complete remission (CR) + CR with incomplete hematologic recovery (CRi). 127 patients were enrolled and randomized in 2:1 ratio. The study showed an increased response rate (CR+CRi of 66.7% vs. 51.2%) in the investigational arm but without statistical significance (p=0.7). A planned sub-group analysis of secondary AML (sAML) patients revealed a more impressive, still non-significant, response rate advantage to the Vyxeos patients (57.6% vs. 31.6%, p=.06) but with significant overall survival (OS) superiority (median 12.1 vs. 6.1 months, HR = 0.46, p=.01).

The phase III trial was an open-labeled randomized trial that enrolled only sAML patients, age 60-75, with the exception of patients with antecedent myeloproliferative neoplasm. Patients received 2-3 cycles (1-2 induction courses and 1 consolidation) of either '7+3' with daunorubicin 60 mg/m2 or Vyxeos. The primary end-point was defined as OS. A total of 309 patients were enrolled and randomized in a 1:1 ratio. This study showed a significant OS (median of 9.56 vs. 5.95 months, HR=0.69, p=.005) and CR+CRi rate (47.7% vs. 33.3%, p=.016) advantage for the patients who received the Vyxeos. These results led the Food and Drug Administration (FDA), in August 2017, to approve the drug for use in the treatment of newly diagnosed therapy-related AML (tAML) and AML with myelodysplasia-related changes (MRC).

Despite the results that highlighted the advantage of Vyxeos for sAML, it is intuitively likely that this powerful drug is also suitable for non-sAML. The mechanism of action is relevant for every AML. Following the FDA approval of the drug for sAML we would like to evaluate its efficacy for low or intermediate risk FLT3-negative de novo AML patients. This consideration is particularly relevant by the inclusion of young AML patients in the study.

Gemtuzumab ozogamicin (GO) Gemtuzumab ozogamicin (Mylotarg) - an anti-CD33 monoclonal antibody linked to calicheamicin, was approved for the treatment of newly diagnosed AML patients, when given as a combination with the '7+3' regimen.

The French Alfa-0701 study evaluated the safety and efficacy of GO administered in a fractionated dosing regimen (3 mg/m² administered on Days 1, 4, and 7) when added to the standard '7+3' regimen. Patients with a CR or CR with incomplete platelet recovery (CRp) received consolidation therapy with 2 courses of treatment including daunorubicin plus cytarabine with or without GO, based on their initial randomization. The primary end point was event free survival (EFS) which was longer in the GO arm; median of 17.3 months (95% combination index (CI): 13.4-30.0) vs 9.5 months (95% CI: 8.1-12.0). 3-years EFS was achieved by 39.8% of the GO arm compared to 13.6% of the control arm. OS was better in the GO arm (27.5 vs. 21.8 months) but have not reached statistical significance (HR 0.807, 95% CI: 0.596-1.093, p=0.1646)5. A meta-analysis of GO in combination with chemotherapy for newly diagnosed AML patients concluded that GO does not increase the CR rate but decreases the relapse rate and improves the OS. The drug is ineffective in high risk patients.

One of the goals of the current study is to examine the feasibility and efficacy of the combination of Mylotarg plus Vyxeos.

Minimal/ measurable residual disease (MRD) Several factors present at diagnosis of AML, including cytogenetics, molecular genetics, and age, have been associated with prognosis. Increasing evidence now indicates that the ability to identify residual disease far below the morphology-based 5% blast threshold is an important tool for refining the approach to risk classification. Minimal or measurable residual disease (MRD) denotes the presence of leukemia cells down to levels of 1:10-4 to 1:10-6, compared with 1:20 in morphology-based assessments. MRD can be evaluated using a variety of multiparameter flow cytometry (MFC) and molecular methods. There are no data regarding the achievement or impact of MRD using Vyxeos as induction therapy. The current trial will address this issue.

Purpose of this Trial The current study is designed to examine the response rate of the Vyxeos as induction therapy for newly diagnosed low/intermediate risk AML patients in the 'real world' setting. Patients will receive the same induction therapy that they were to receive had they not entered this study (cytarabine /daunorubicin ± Mylotarg) but the combination of cytarabine /daunorubicin will be given in the unique formulation of Vyxeos. In addition to classic CR+CRi evaluation, MFC MRD evaluation, using an centralized, internationally recognized laboratory, will be done at the end of induction. In addition, this pilot study will also provide clinical safety information about the combination of Vyxeos with Mylotarg.

Gender and Ethnicity Entry to this study is open to both men and women, and to persons of any racial or ethnic group. We are aware of no data that would lead us to expect differential treatment effects by gender and ethnicity and therefore have not incorporated separate accrual goals for these subgroups.

Vyxeos for Induction of Low- or Intermediate-risk.

Vyxeos for Induction of Newly Diagnosed Low- or Intermediate-risk AML Patients, Age 18-70. A Pilot Study

There is no plan to share individual participant data (IPD) available to other researchers.

Complete Remission (CR) and Complete Remission with incomplete Hematologic Recovery (CRi) rate.

Number and severity of adverse events (AEs) and adverse events serious adverse events (SAEs) of participants with Vyxeos plus Mylotarg treatment. AEs and SAEs of both treatment and non-treatment-related will be collected at REDCAP project and assessed by CTCAE v5.0.

Multiparameter Flow Cytometry Minimal Residual Disease (MFC MRD) levels before and after Vyxeos will be collected.

Multiparameter Flow Cytometry Minimal Residual Disease (MFC MRD) levels before and after Vyxeos and Mulotarg will be collected.

Disease free survival (DFS) post Vyxeos ± Mylotarg induction therapy by testing disease status as schedule:

During 1st year - every 3 months During 2nd year - every 6 months For the following 3 years, once a year, or in a case known of disease relapse.

Overall survival (OS) post Vyxeos ± Mylotarg induction therapy by testing survival status monthly.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
A Trial of Treatments to Assess the Effects on Outcome of Adults With AML and MDS Undergoing Allogeneic SCT	NCT04217278	Acute Myeloid L... High-risk Myelo...	Vyxeos Fludarabine Busulphan Thiotepa Cytarabine	18 Years -	University of Birmingham
Venetoclax Combined With Vyxeos (CPX-351) for Participants With Relapsed or Refractory Acute Leukemia	NCT03826992	Leukemia	Vyxeos Venetoclax	1 Year - 39 Years	Children's Hospital Medical Center, Cincinnati
CPX-351 in Combination With Gemtuzumab Ozogamicin in Newly Diagnosed AML	NCT05558124	Acute Myeloid L...	Vyxeos Gemtuzumab Ozog...	18 Years - 70 Years	H. Lee Moffitt Cancer Center and Research Institute
Venetoclax Combined With Vyxeos (CPX-351) for Participants With Relapsed or Refractory Acute Leukemia	NCT03826992	Leukemia	Vyxeos Venetoclax	1 Year - 39 Years	Children's Hospital Medical Center, Cincinnati
EAP of CPX-351 (VYXEOS) for Patients 60-75 Years of Age With Secondary AML	NCT02533115	Secondary AML	CPX-351	60 Years - 75 Years	Jazz Pharmaceuticals
Vyxeos for Induction of Low- or Intermediate-risk.	NCT05599360	Leukemia, Myelo...	Vyxeos Mylotarg	18 Years - 70 Years	Shaare Zedek Medical Center

Spots Global Cancer Trial Database for vyxeos

Every month we try and update this database with for vyxeos cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for vyxeos

Every month we try and update this database with for vyxeos cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for vyxeos cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.