Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Behaviors and Mental Disorders

Prostatic Neoplasms

Genital Neoplasms, Male

Urogenital Neoplasms

Genital Diseases

Genital Diseases, Male

Urogenital Diseases

Prostatic Diseases

Male Urogenital Diseases

Quality of Life

All Drugs and Chemicals

Androgens

Intervention will involve 3 sessions per week of a structured and supervised walking football program over 16 weeks. Each session will include a warm-up, followed by the practice of specific exercises where specific technical skills (pass, dribble, shot), motor skills (agility, coordination, balance) and physical fitness (cardiorespiratory and musculoskeletal capacity) will be enhanced, ending with a structured game (7x7) of walking football and a cooldown.

Walking football training

Andreia Capela, MD

Androgen deprivation therapy (ADT) is widely used in men with prostate cancer (PCa) to delay disease progression and enhance survival. The use of ADT is often associated with a vast spectrum of side effects that considerably reduce quality of life. Exercise has been proposed as a non-pharmacological strategy to counter some adverse effects of ADT among patients with PCa. Particularly, recreational football-based interventions have been suggested as an enjoyment approach to involve patients with PCa in regular exercise practice. Given its intermittent nature and vigorous efforts, adverse events associated with recreational football practice have been reported. To handle this issue and to involve patients with PCa in recreational football practice, walking football has emerged as a more suitable exercise modality

This study was design as a randomized controlled trial, with two study arms, which aims to analyse the feasibility, safety of a supervised walking football program in patients with PCa. Moreover, the effects on health-related quality of life; bone mineral density; body composition; physical fitness; physical activity levels; inflammatory and metabolic profile; cognitive function; and cost-effectiveness will be complementarily analysed.

Recruitment will be conducted by invitation of Centro Hospitalar de Vila Nova de Gaia/Espinho (CHVNG/E; Vila Nova de Gaia, Portugal, E.P.E) oncologists and urologists. Patients who agree to participate in this study will be referred to a study coordinator (medical oncologist) and will be randomly allocated (1:1 ratio) to one of the two study-arms.

In addition to standard PCa care, patients in the interventional group (IG) will perform 3 times per week a supervised Walking Football Program over 16 weeks and plus 16 additional weeks.

Patients allocated to control group (CG) will receive standard PCa medical care and will be instructed to maintain daily-life routines. After the first 16 weeks, the control group patients' will be invited to join and preform the exercise intervention (additional 16 weeks).

Walking football exercise sessions will be conducted on an indoor sports hall, supervised by one exercise physiologist and a football coach. Exercise intensity will be monitored through heart rate and rated perceived exertion.

Walking Football as a Supportive Medicine for Patients With Prostate Cancer

Is the Walking Football a Feasible Approach to Improve Health-related Quality of Life in Men With Prostate Cancer Receiving Androgen Deprivation Therapy? the PROSTATA_MOVE Randomized Controlled Trial.

Assessed by the number of enrolled patients divided by the number of invited patients.

Assessed by the number of withdrawal patients

Assessed by the percentage of completed data.

Assessed by the number of completed sessions and the number of missed sessions.

Assessed by the self-reported exercise sessions' enjoyment using a likert scale (1 \[lowest\] to 5 \[highest\] points).

Using EORTC PR25, EQ-5D-5L and SF-6D questionnaire.

Assessed by a whole-body dual-energy X-ray absorptiometry (DXA) scan.

Assessed by a symptom-limited exercise test on a treadmill

Assessed using a digital handgrip dynamometer.

Assessed by the 30-seconds sit-to-stand test

Distance (km) assessed using GPS tracking during exercise

Assessed using a 6-20 borg scale (minimum effort = 6; maximum effort = 10).

Assessed by the Montreal Cognitive Assessment

Assessed using a digital sphygmomanometer

Blood sample will be taken for analysis of levels of LDL-cholesterol

Blood sample will be taken for analysis of levels of HDL-cholesterol

Blood sample will be taken for analysis of levels of total cholesterol

Blood sample will be taken for analysis of levels of triglycerides

Blood sample will be taken for analysis of levels of PSA

Blood sample will be taken for analysis of levels of creatinine

Blood sample will be taken for analysis of levels of HS-CRP

Blood sample will be taken for analysis of levels of NT-proBNP

Blood sample will be taken for analysis of levels of vitamin D

Blood sample will be taken for analysis of levels of

Blood sample will be taken for analysis of levels of CTx

Blood sample will be taken for analysis of levels of BSAP

Blood sample will be taken for analysis of levels of TRAP

Blood sample will be taken for analysis of levels of glycated hemoglobin

Blood sample will be taken for analysis of levels of testosterone

Spots Global Cancer Trial Database for walking football training