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Protein Kinase Inhibitors

Xiang Sha Liu Jun Zi Decoction dry powder 7.5g/day tid

10%Xiang Sha Liu Jun Zi Decoction dry powder 7.5g/day tid

the principles of Chinese medicine treatment areinvigorating Pi, regulating qi, dissipating dampness and appetizing wei

Xiang Sha Liu Jun Zi Decoction dry powder

XSLJZ Placebo

YuanChing Liao

The purpose of the study was search the safety and efficacy of the of Xiang Sha Liu Jun Zi Decoction (XSLJZ) in advanced hepatocellular carcinoma patients with multiple protein kinase inhibitor therapy. Evaluate the treatment effect on the symptoms of appetite and quality of life in advanced hepatocellular carcinoma patients

Hepatocellular carcinoma (HCC) is the top fourth most common cancer in Taiwan. Approximately 85% of cases of HCC patients had chronic HBV or HCV infection in Taiwan. Metabolic risk factors, such as obesity, fatty liver, high lipidemia, and diabetes mellitus are associated with increased risk for nonviral hepatocellular carcinoma.

The first and second-line systemic therapy approved in advanced hepatocellular carcinoma are multikinase inhubitors .Sorafenib (Nexavar)、Regorafenib and Lenvatinib are significantly improve survival in patients who had unresectable advanced and/or metastatic HCC not amenable to local treatment methods. General fatigue, poor appetite and pain are regarded as common and unavoidable side effect experienced during the course of cancer and its treatment. Anorexia is a common cause of malnutrition and is associated with negative effects on the quality of life (QOL) for patients with cancer. However, quality of life as a prognostic factor for survival in hepatocellular carcinoma. Management of appetite is the key to improving both the QOL and the prognosis for such patients.

Cancer-related anorexia and target therapy-induced anorexia is very important in HCC patients. According to Chinese medicine theory., "spleen-deficiency, qi-stagnation and dampness" are the most common syndrome in advanced hepatocellular carcinoma patients. Thus, the principles of Chinese medicine treatment are invigorating Pi, regulating qi, dissipating dampness and appetizing wei. Most patients received traditional Chinese medicine treatment as adjuvant therapy to alleviate cancer symptoms, diminishing the side effects and complications of treatment course at late stages. The purpose of the study was search the safety and efficacy of the of Xiang Sha Liu Jun Zi Decoction (XSLJZ) in advanced hepatocellular carcinoma patients with multiple protein kinase inhibitor therapy. Evaluate the treatment effect on the symptoms of appetite and quality of life in advanced hepatocellular carcinoma patients

The Safety and Efficacy Evaluation of XSLJZ in Advanced Hepatocellular Carcinoma Patients With Multiple Protein Kinase Inhibitor Therapy: A Randomized, Double-Blind, Controlled Trial

European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire score

European Organization for Research and Treatment of Hepatocellular carcinoma Core Quality of Life Questionnaire score

cancer appetite and symptom questionnaire

Functional Assessment of Cancer Therapy - General

tong diagnosis by Automatic Tongue Diagnosis System

pulse diagnosis by Huang's Sphygmography in Frequeny-domained Parameters

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
The Safety and Efficacy Evaluation of XSLJZ in Advanced Hepatocellular Carcinoma Patients With Multiple Protein Kinase Inhibitor Therapy: A Randomized, Double-Blind, Controlled Trial	NCT04562428	Hepatocellular ...	Xiang Sha Liu J... XSLJZ Placebo	20 Years - 75 Years	China Medical University Hospital
The Safety and Efficacy Evaluation of XSLJZ in Advanced Hepatocellular Carcinoma Patients With Multiple Protein Kinase Inhibitor Therapy: A Randomized, Double-Blind, Controlled Trial	NCT04562428	Hepatocellular ...	Xiang Sha Liu J... XSLJZ Placebo	20 Years - 75 Years	China Medical University Hospital

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