Substance Related Disorders

Behaviors and Mental Disorders

All Conditions

Neoplasms

Symptoms and General Pathology

Tobacco Use Disorder

Carcinogenesis

Substance-Related Disorders

Chemically-Induced Disorders

Mental Disorders

Psychotic Disorders

Neoplastic Processes

All Drugs and Chemicals

Nicotine

15 participants will be randomly assigned to receive ZYN Pouches with 3mg nicotine concentration.

15 participants will be randomly assigned to receive ZYN Pouches with 6mg nicotine concentration.

30 current non-treatment seeking adult smokers will be switched from smoking cigarettes to ZYN oral nicotine pouches containing either 3mg or 6mg concentration nicotine salts.

This study aims to assess the feasibility, acceptability, and the potential harm reduction of switching to potentially lower risk, oral nicotine pouches in adult smokers. Part One of this study aims to assess the interest of current smokers in switching to an e-cigarette device (i.e. JUUL) compared to alternative non-combustible tobacco products (i.e. smokeless tobacco/snus) and/or medicinal nicotine via survey. Part Two will consist of a pilot study of 30 non-treatment seeking adult smokers to investigate within-person changes in smoking behavior as a result of switching to different concentrations of oral nicotine pouch products (i.e. ZYN, 3mg and 6mg nicotine concentration). Additionally, by measuring bio-markers of tobacco exposure from baseline, this will allow the study to assess the potential for harm reduction in switching from cigarettes to oral nicotine pouches.

30 current non-treatment seeking adult smokers will be randomized to either the 3mg or 6mg nicotine concentration ZYN condition.

Switching to Potential Reduced Exposure Products in Adult Smokers

Switching to a Non-tobacco-based Oral Nicotine Product Among Adult Cigarette Smokers: Exploring the Roles of Product Characteristics and User History

The investigators will compare whether smoking behavior varies by the 3mg and 6mg nicotine concentrations as measure by the standardized Timeline Followback Interview.

To investigate whether switching behavior varies by the 3mg and 6mg nicotine concentrations

The investigators will compare whether the smoke free days vary by the 3mg and 6mg nicotine concentrations

Participants will provide repeated lab samples for biomarker assessments. Urine samples obtained will be compared at baseline and week 4 for differences by group and by time.

To evaluate the acceptability of switching, participants will also be asked how likely it is that they will continue to use ZYN oral nicotine patches for cigarette substitution compared to cigarettes on a question designed for this trial.

Yale University

15 participants will be randomly assigned to receive ZYN Pouches with 3mg nicotine concentration.

ZYN: 30 current non-treatment seeking adult smokers will be switched from smoking cigarettes to ZYN oral nicotine pouches containing either 3mg or 6mg concentration nicotine salts.

3mg Nicotine Concentration

15 participants will be randomly assigned to receive ZYN Pouches with 6mg nicotine concentration.

ZYN: 30 current non-treatment seeking adult smokers will be switched from smoking cigarettes to ZYN oral nicotine pouches containing either 3mg or 6mg concentration nicotine salts.

6mg Nicotine Concentration

Total

Age, Continuous

Sex: Female, Male

Ethnicity (NIH/OMB)

Race Customized

Race/Ethnicity, Customized

United States

Region of Enrollment

This is binary count of yes/no responses to whether or not participants smoke their first cigarette within 30 minutes of waking in the morning.

Spots Global Cancer Trial Database for zyn

Every month we try and update this database with for zyn cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for zyn

Every month we try and update this database with for zyn cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for zyn cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.