Heart and Blood Diseases

Symptoms and General Pathology

All Conditions

Rare Diseases

Myocardial Infarction

Infarction

Ischemia

Necrosis

Coronary Artery Disease

Myocardial Ischemia

Heart Diseases

Vascular Diseases

Acute Graft Versus Host Disease

Cancer patients with diagnosis of acute myocardial infarction that was treated with PCI or CABG

Cancer patients with diagnosis of acute myocardial infarction that was treated with medical treatment only

Revascularization

Joo Myung Lee, MD, MPH, PhD

Seung Hun Lee, MD, PhD

Using national health insurance service database, current study aim to evaluate the risk and prognosis of acute myocardial infarction in cancer patients and to find the optimal treatment strategy for acute myocardial infarction that can improve long-term prognosis.

This study will be conducted using Korean National Health Insurance Service database. Patients who were diagnosed with cancer from 2002 to 2021 will be included in the study. Using the selected patients, current study will analyze the incidence and prognosis of acute myocardial infarction in cancer patients and the prognosis according to the treatment method for acute myocardial infarction will be compared. Primary outcome will be all-cause death. Secondary outcomes will be myocardial infarction, revascularization, hospitalization for heart failure, stroke, and clinically relevant bleeding.

Acute Myocardial Infarction in Cancer Patients

Risk and Clinical Outcomes of Acute Myocardial Infarction in Patients With Cancer: A Nationwide Study

This is National Health Insurance Data Analysis. Therefore, sharing the original patient-level data is not possible under regulation by the Korean government.

All-cause death which was obtained from death certification collected by Statistics Korea at the Ministry of Strategy and Finance of South Korea

Myocardial infarction is defined as presence of the diagnostic codes (ICD-10 I21, I22) in the primary position during hospitalization

Percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG)

Heart failure events requiring hospitalization defined as presence of the diagnostic codes (I110, I130, I132, I255, I420, I425-I429, I43, I50, I971) in the primary position during hospitalization

Stroke is defined as ischemic stroke (ICD-10 I63, I64) or intracranial hemorrhage (ICD-10 I60-62), combined with the codes of diagnostic brain imaging.

Bleeding requiring hospitalization or transfusion

Chonnam National University

Samsung Medical Center

Associate Professor

Neoplasms

Skin and Connective Tissue Diseases

Gland and Hormone Related Diseases

Digestive System Diseases

Breast Neoplasms

Thyroid Diseases

Liver Diseases

Breast Diseases

Fibrocystic Breast Disease

Gastrointestinal Diseases

Skin Diseases

Endocrine System Diseases

Chronic Graft Versus Host Disease

The goal of this observational study is to compare the image differences between conventional ultrasound and artificial intelligence-based ultrasound software in conscious adults.

The main question it aims to answer is to evaluate the effectiveness by determining that the new image analysis method is considered valid if it helps to identify more than 30% of histological characteristics.

Participants will undergo the examination using the two methods mentioned earlier after signing the consent form.

The Development of Quantitative Ultrasound Imaging Software Platform

The Development of Artificial Intelligence (AI) Based High Performance Structural-functional and Quantitative Ultrasound Imaging Software Platform

Quantitative ultrasound images of heart, thyroid, and breast disease

Seoul National University Bundang Hospital

Cardiomyopathies

Takotsubo Cardiomyopathy

Ventricular Dysfunction, Left

Ventricular Dysfunction

Broken Heart Syndrome

Short term psychotherapy + Classic cardiological therapy

Short term psychotherapy + Classic oncological therapy

Humanistic-existential psychotherapy derived from ontopsychological method and specifically adapted to public health systems. Individual and group sessions to be tailored to individual needs

Short Term Psychotherapy

Adriana Roncella, MD

Psychological processes play a complex role in the pathophysiology of many diseases. However, the body and emotional perception of patients and the relationship between dreams and disease still need to be investigated.

The investigators planned an observational and controlled research aimed at assessing some previously unaddressed baseline psychological characteristics and their changes at 1 and 5 years after a short-term psychotherapy in carefully characterised patients with heart or oncologic diseases .

The patients that will be enrolled are:

* 50 patients ≤ 75 year old with acute myocardial infarction;
* 30 patients ≤ 75 year old with Tako-Tsubo syndrome;
* 50 women ≤ 75 year old, recently operated on breast cancer:
* 90 control subjects of the same age and gender of the enrolled patients, without relevant pathologies during the last 10 years. Relevant pathologies are defined as those that required a hospitalisation or a long-lasting medical therapy.

At the enrolment all the subjects will undergo a complete medical evaluation, and the following psychometric tests: Self-evaluation test, Social Support Questionnaire, Beck Depression Inventory II (BDI II), MacNew Heart Disease Health-Related Quality of Life Questionnaire, State-Trait Anxiety Inventory (STAI), State-Trait Anger Expression Inventory (STAXI 2).

In two distinct following meetings, an open questionnaire exploring the body and emotional perception, and another exploring past and recent dreams, will be administered.

The same evaluation will be done for the healthy subjects.

After the initial evaluation, all the patients will be given the choice to start a short-term psychotherapy lasting 6 months on top of medical therapy or to continue classic medical therapy only. Healthy subjects will be not offered the possibility to follow psychotherapy.

At first year of follow-up, the battery of psychometric test, and the two questionnaires exploring the body and emotional perception, and changes and characteristics of dreams during the psychotherapy, will be re-administered.

The following data will be evaluated:

Psychological characteristics at follow-up. Incidence of new relevant medical events Quality of life Relationship between psychological characteristics and health status, and quality of life

At 5 year follow-up psychometric tests and the clinical data will be evaluated in all the groups.

Psyhosomatic Medicine in Oncologic and Cardiac Disease Study

Retrospective and Prospective Observational Study on Cardiological and Oncological Psychosomatics

Relevant medical events are defined as any new medical condition significantly impairing normal daily activities or requiring hospitalization or needing specific and permanent drug treatment.

These changes will be evaluated with dedicated qualitative questionnaires formulated with open questions.

Number of rehospitalisations during the first year of follow-up

Number of rehospitalisations during 5 years follow-up

Self-evaluation test (score range 1-10, higher stress for higher values)

Beck depression inventory II (score range 0-63, more severe depression symptoms for higher values)

Social support questionnaire (score range 12-72, the higher the score the lower the support)

Mac New Health-related quality of life questionnaire (score range 1-7, the higher the score the higher the quality of life, 4 subscales not merged)

State-Trait Anxiety inventory (score range 20-80, the higher the score the more anxiety the patients has, 2 subscales)

State-Trait Anger Expression inventory (score range 0%-100%, the higher the score the higher the anger, two subscales)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Acute Myocardial Infarction in Cancer Patients	NCT06281054	Acute Myocardia... Cancer	Revascularizati...	-	Samsung Medical Center
The Development of Quantitative Ultrasound Imaging Software Platform	NCT05836246	Chronic Liver D... Thyroid Disease Benign Breast D... Malignant Breas... Acute Myocardia...		18 Years -	Seoul National University Bundang Hospital
Psyhosomatic Medicine in Oncologic and Cardiac Disease Study	NCT03437642	Acute Myocardia... Tako Tsubo Card... Breast Cancer	Short Term Psyc...	18 Years - 75 Years	San Filippo Neri General Hospital
Psyhosomatic Medicine in Oncologic and Cardiac Disease Study	NCT03437642	Acute Myocardia... Tako Tsubo Card... Breast Cancer	Short Term Psyc...	18 Years - 75 Years	San Filippo Neri General Hospital
Acute Myocardial Infarction in Cancer Patients	NCT06281054	Acute Myocardia... Cancer	Revascularizati...	-	Samsung Medical Center
The Development of Quantitative Ultrasound Imaging Software Platform	NCT05836246	Chronic Liver D... Thyroid Disease Benign Breast D... Malignant Breas... Acute Myocardia...		18 Years -	Seoul National University Bundang Hospital
The Development of Quantitative Ultrasound Imaging Software Platform	NCT05836246	Chronic Liver D... Thyroid Disease Benign Breast D... Malignant Breas... Acute Myocardia...		18 Years -	Seoul National University Bundang Hospital

Spots Global Cancer Trial Database for acute myocardial infarction