Heart and Blood Diseases

All Conditions

Symptoms and General Pathology

Aneurysm

Nausea

Vomiting

Antipyretics

Analgesics

All Drugs and Chemicals

Central Nervous System Depressants

Acetaminophen

Analgesics, Opioid

Analgesics, Non-Narcotic

Craniotomy patients will receive a 1000 mg dose of intravenous (IV) acetaminophen before incision and a second 1000 mg dose of IV acetaminophen 6 hours later.

Patients will receive standard of care with no intraoperative doses of acetaminophen.

1000 mg dose intravenous acetaminophen before craniotomy incision and a second 1000 mg dose intravenous acetaminophen 6 hours after surgery

Becky Wood

Nathan Hansen

Arthur Lam, MD, FRCPC

Adding intraoperative IV acetaminophen, in addition to standard analgesics, will decrease opioid requirements over the first 12 hours of postoperative recovery following craniotomy. Opioids exacerbate symptoms of nausea and vomiting. Reducing postoperative opioid use hopefully will reduce incidence of nausea and vomiting in patients after craniotomy.

Intravenous Acetaminophen for Craniotomy Patients

Intravenous Acetaminophen for Craniotomy Patients: A Single-blinded, Randomized Controlled Trial to Evaluate the Effect of Intravenous Acetaminophen Administered at Induction and Emergence From Craniotomy

Intensive care nurses will ask subject about pain and nausea every 15 minutes for the first two hours immediately after surgery and then every hour afterward for up to 12 hours. Nurses will record subject response and opioid doses given.

Mallinckrodt

Swedish Medical Center

Rare Diseases

Myocardial Infarction

Infarction

Ischemia

Necrosis

Coronary Artery Disease

Myocardial Ischemia

Heart Diseases

Vascular Diseases

Acute Graft Versus Host Disease

Cancer patients with diagnosis of acute myocardial infarction that was treated with PCI or CABG

Cancer patients with diagnosis of acute myocardial infarction that was treated with medical treatment only

Revascularization

Joo Myung Lee, MD, MPH, PhD

Seung Hun Lee, MD, PhD

Using national health insurance service database, current study aim to evaluate the risk and prognosis of acute myocardial infarction in cancer patients and to find the optimal treatment strategy for acute myocardial infarction that can improve long-term prognosis.

This study will be conducted using Korean National Health Insurance Service database. Patients who were diagnosed with cancer from 2002 to 2021 will be included in the study. Using the selected patients, current study will analyze the incidence and prognosis of acute myocardial infarction in cancer patients and the prognosis according to the treatment method for acute myocardial infarction will be compared. Primary outcome will be all-cause death. Secondary outcomes will be myocardial infarction, revascularization, hospitalization for heart failure, stroke, and clinically relevant bleeding.

Acute Myocardial Infarction in Cancer Patients

Risk and Clinical Outcomes of Acute Myocardial Infarction in Patients With Cancer: A Nationwide Study

This is National Health Insurance Data Analysis. Therefore, sharing the original patient-level data is not possible under regulation by the Korean government.

All-cause death which was obtained from death certification collected by Statistics Korea at the Ministry of Strategy and Finance of South Korea

Myocardial infarction is defined as presence of the diagnostic codes (ICD-10 I21, I22) in the primary position during hospitalization

Percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG)

Heart failure events requiring hospitalization defined as presence of the diagnostic codes (I110, I130, I132, I255, I420, I425-I429, I43, I50, I971) in the primary position during hospitalization

Stroke is defined as ischemic stroke (ICD-10 I63, I64) or intracranial hemorrhage (ICD-10 I60-62), combined with the codes of diagnostic brain imaging.

Bleeding requiring hospitalization or transfusion

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Intravenous Acetaminophen for Craniotomy Patients	NCT01474304	Craniotomy	Acetaminophen	18 Years -	Swedish Medical Center
Intravenous Acetaminophen for Craniotomy Patients	NCT01474304	Craniotomy	Acetaminophen	18 Years -	Swedish Medical Center
Acute Myocardial Infarction in Cancer Patients	NCT06281054	Acute Myocardia... Cancer	Revascularizati...	-	Samsung Medical Center
Intravenous Acetaminophen for Craniotomy Patients	NCT01474304	Craniotomy	Acetaminophen	18 Years -	Swedish Medical Center
Intravenous Acetaminophen for Craniotomy Patients	NCT01474304	Craniotomy	Acetaminophen	18 Years -	Swedish Medical Center
Acute Myocardial Infarction in Cancer Patients	NCT06281054	Acute Myocardia... Cancer	Revascularizati...	-	Samsung Medical Center

Spots Global Cancer Trial Database for revascularization